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Novel aceglutamide compound and pharmaceutical composition thereof

A technology of acetylglutamine and compounds, applied in the field of novel acetylglutamine compounds and pharmaceutical compositions of said acetylglutamine compounds, capable of solving the problems of strong irritation of liquid medicine, affecting the popularization and application of acetylglutamine, and low purity. Reach the effect of reducing blood ammonia

Active Publication Date: 2013-04-03
东台海滨科技创业园管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing acetylglutamine generally has problems such as low purity, poor product quality stability, strong liquid irritation, and high failure rate of clarity, which seriously affects the popularization and application of acetylglutamine.

Method used

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  • Novel aceglutamide compound and pharmaceutical composition thereof
  • Novel aceglutamide compound and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pharmaceutical composition of an acetylglutamine compound, the pharmaceutical composition is an injection, and the injection is prepared by the following method:

[0023] (1) Take 400 ml of water for injection and place it in a container, then add 400 mg of alliin, 10 mg of mannitol, 50 mg of disodium hydrogen phosphate and 5 mg of sodium dihydrogen phosphate, dissolve and add activated carbon, filter to form solution A;

[0024] (2) Take 100ml of water for injection and place it in another container, slowly add 900mg of acetylglutamine, and stir until the acetylglutamine is completely dissolved to form solution B;

[0025] (3) Add solution B to solution A, add water for injection to 1000ml, add activated carbon again, stir and filter to form solution C;

[0026] (4) Detect the content of acetylglutamine in solution C, and the qualified solution can be packaged after fine filtration, potting and sterilization to form acetylglutamine injection.

Embodiment 2

[0028] A pharmaceutical composition of an acetylglutamine compound, the pharmaceutical composition is an injection, and the injection is prepared by the following method:

[0029] (1) Take 400 ml of water for injection and place it in a container, then add 60 mg of alliin, 80 mg of mannitol, 8 mg of disodium hydrogen phosphate and 30 mg of sodium dihydrogen phosphate, dissolve and add activated carbon, filter to form solution A;

[0030] (2) Take 150ml of water for injection and put it in another container, slowly add 6g of acetylglutamine, and stir until the acetylglutamine is completely dissolved to form solution B;

[0031] (3) Add solution B to solution A, add water for injection to 1000ml, add activated carbon again, stir and filter to form solution C;

[0032] (4) Detect the content of acetylglutamine in solution C, and the qualified solution can be packaged after fine filtration, potting and sterilization to form acetylglutamine injection.

Embodiment 3

[0034] A pharmaceutical composition of an acetylglutamine compound, the pharmaceutical composition is an injection, and the injection is prepared by the following method:

[0035] (1) Take 400 ml of water for injection and place it in a container, then add 200 mg of alliin, 50 mg of mannitol, 30 mg of disodium hydrogen phosphate and 20 mg of sodium dihydrogen phosphate, dissolve and add activated carbon, filter to form solution A;

[0036] (2) Take 100ml of water for injection and put it in another container, slowly add 3g of acetylglutamine, and stir until the acetylglutamine is completely dissolved to form solution B;

[0037] (3) Add solution B to solution A, add water for injection to 1000ml, add activated carbon again, stir and filter to form solution C;

[0038] (4) Detect the content of acetylglutamine in solution C, and the qualified solution can be packaged after fine filtration, potting and sterilization to form acetylglutamine injection.

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PUM

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Abstract

The invention discloses a novel aceglutamide compound. The purity of the compound is greater than 99.6%. At the same time, the invention further discloses a pharmaceutical composition of the novel aceglutamide compound. The composition comprises the following components in parts by weight: 90-600 parts of aceglutamide, 6-40 parts of alliin, 1-8 parts of mannitol, 0.8-5 parts of disodium hydrogen phosphate and 0.5-3 parts of sodium dihydrogen phosphate. In the pharmaceutical composition of the novel aceglutamide compound disclosed by the invention, the synergistic effect is generated among the mannitol, the disodium hydrogen phosphate and the sodium dihydrogen phosphate, so that the stability of the composition under high temperature, high humidity and bright light is enhanced; and the aceglutamide and the alliin mutually take synergistic effect and can play a role of observably reducing blood ammonia.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel acetylglutamine compound and a pharmaceutical composition of the acetylglutamine compound. Background technique [0002] Acetylglutamine, also known as acetate glutamine, amide glutarate, is the acetyl compound of glutamine, which can improve nerve cell metabolism, maintain nerve stress ability and reduce blood ammonia, and can pass through the blood-brain barrier. For brain surgery coma, hepatic coma, hemiplegia, high paraplegia, sequelae of poliomyelitis, sequelae of traumatic brain injury, mental retardation, nervous headache and low back pain, etc. The existing acetylglutamine generally has problems such as low purity, poor product quality stability, strong liquid irritation, and high failure rate of clarity, which seriously affects the popularization and application of acetylglutamine. Contents of the invention [0003] The object of the present invention is to overcome th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/22C07C231/24A61K31/198A61K9/08A61K9/19A61K47/10A61K47/04A61P25/00A61P3/00A61P1/16
Inventor 黄明芳
Owner 东台海滨科技创业园管理有限公司
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