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Preparation of aceglutamide

A technology of acetylglutamine and glutamine, which is applied in the field of preparation of acetylglutamine, can solve the problems of long production time, large amount of raw materials used, and low yield, and achieve the effect of long production time and increased manpower and material costs

Active Publication Date: 2009-05-20
SHANGHAI ZHAOHUI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The analysis, product testing and process of the above-mentioned preparation method are relatively complicated, the production time is long, the amount of raw materials used is large, the cost is high, and the yield is low. Exceeding the standard and failing the test

Method used

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  • Preparation of aceglutamide

Examples

Experimental program
Comparison scheme
Effect test

example 1-9

[0032] Example 1-9: The operating process parameters are set in the following table

[0033] example double drop

time hr double drop

temperature °C During neutralization

time hr Neutral and warm

degree ℃ when crystallized

Between min dry water

Temperature 1℃ when dry

Between hr dry water

Temperature 2℃ when dry

Between hr 1 2 5 2 3 30 35 2 50 2 2 2 10 2 6 30 40 2 60 2 3 2 15 2 9 30 45 2 70 2 4 2.5 5 2.5 3 45 35 2 50 2 5 2.5 10 2.5 6 45 40 2 60 2 6 2.5 15 2.5 9 45 45 2 70 2 7 3 5 3 3 60 35 2 50 2 8 3 10 3 6 60 40 2 60 2 9 3 15 3 9 60 45 2 70 2

[0034] .

[0035] Process of the present invention and former process product synthesis time, yield, related substance result comparison:

[0036]

[0037] From the above 10 examples, after the present invention adopts the ...

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Abstract

The invention provides a preparation method of acetylglutamine, which includes the steps of acylation neutralization reaction, refining, drying and the like. Based on the original technology, the preparation method saves the technological processes of drying, heating and dissolving crude products. After neutralization reaction, filtration and the preparation of the crude products, alcohol is directly used for dissolving crystals and an end product is obtained by drying. The preparation method is simple, and has low cost, high product yield and good quality. All indicators are fully consistent with the existing quality standards; therefore, the preparation method is applicable to industrialized production.

Description

Technical field: [0001] The present invention relates to medicinal chemistry. Specifically relates to the preparation method of acetylglutamine. Background technique: [0002] Acetylglutamine is a drug for improving brain function, which can improve nerve cell metabolism, maintain nerve stress ability and reduce blood ammonia, and improve brain function. Clinically, it is mainly used for coma, paralysis, mental decline, and memory impairment caused by hepatic coma, hemiplegia, high paraplegia, sequelae of poliomyelitis, and neurosurgery. [0003] The preparation method of existing acetylglutamine is [0004] 1. Acylation reaction [0005] Feeding ratio [0006] raw material name Feeding amount (kg) L-Glutamine 50 purified water 250 Acetic anhydride 42 Sodium Hydroxide (Industrial) 25 Hydrochloric acid (industrial) 80 [0007] Preparation: [0008] Put 250kg of purified water into the 500L acylation reaction pot; start stirri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/06C07C231/14
Inventor 刁益民熊洁付林王逸智包丽敏
Owner SHANGHAI ZHAOHUI PHARMA
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