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Preparation of aceglutamide

A technology of acetoglutamine and formula, applied in the field of preparation of acetoglutamine, can solve the problems of long production time, unqualified exceeding standard, large amount of raw materials used, etc., and achieves long production time, complete product quality, and increased labor and material cost. Effect

Active Publication Date: 2012-01-04
SHANGHAI ZHAOHUI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The analysis, product testing and process of the above-mentioned preparation method are relatively complicated, the production time is long, the amount of raw materials used is large, the cost is high, and the yield is low. Exceeding the standard and failing the test

Method used

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  • Preparation of aceglutamide
  • Preparation of aceglutamide

Examples

Experimental program
Comparison scheme
Effect test

example 1-9

[0031] Example 1-9: The operating process parameters are set in the following table

[0032] example

double drop

time hr

double drop

temperature °C

Neutralization

Between hr

Neutral and warm

degree ℃

when crystallized

Between min

dry water

Temperature 1℃

when dry

Between hr

dry water

Temperature 2℃

when dry

Between hr

1

2

5

2

3

30

35

2

50

2

2

2

10

2

6

30

40

2

60

2

3

2

15

2

9

30

45

2

70

2

4

2.5

5

2.5

3

45

35

2

50

2

5

2.5

10

2.5

6

45

40

2

60

2

6

2.5

15

2.5

9

45

45

2

70

2

7

3

5

3

...

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Abstract

The invention provides a preparation method of acetylglutamine, which includes the steps of acylation neutralization reaction, refining, drying and the like. Based on the original technology, the preparation method saves the technological processes of drying, heating and dissolving crude products. After neutralization reaction, filtration and the preparation of the crude products, alcohol is directly used for dissolving crystals and an end product is obtained by drying. The preparation method is simple, and has low cost, high product yield and good quality. All indicators are fully consistentwith the existing quality standards; therefore, the preparation method is applicable to industrialized production.

Description

Technical field: [0001] The present invention relates to medicinal chemistry. Specifically relates to the preparation method of acetylglutamine. Background technique: [0002] Acetylglutamine is a drug for improving brain function, which can improve the metabolism of nerve cells. Maintain nerve stress ability and reduce blood ammonia, improve brain function. Clinically, it is mainly used for coma, paralysis, mental decline, and memory impairment caused by hepatic coma, hemiplegia, high paraplegia, sequelae of poliomyelitis, and neurosurgery. [0003] The preparation method of existing acetylglutamine is [0004] 1. Acylation reaction [0005] Feeding ratio [0006] raw material name Feeding amount (kg) L-Glutamine 50 purified water 250 Acetic anhydride 42 Sodium Hydroxide (Industrial) 25 Hydrochloric acid (industrial) 80 [0007] Preparation: [0008] Put 250kg of purified water int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C237/06C07C231/14
Inventor 刁益民熊洁付林王逸智包丽敏
Owner SHANGHAI ZHAOHUI PHARMA