Use of pharmaceutical composition containing aceglutamide and safflower

A kind of technology of acetoglutamine and composition, applied in the application field of medicine

Active Publication Date: 2006-10-11
通化谷红制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the application of drugs containing acetylglutamine and safflower pharmaceutical composition for promoting tissue injury healing and recovery has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0015] Objective: To test the curative effect of a pharmaceutical composition containing acetylglutamine and safflower in promoting fracture healing and recovery.

[0016] 1 material

[0017] 1.1 Experimental animals: 28 healthy rabbits, weighing 2.10-2.15kg, half male and half male.

[0018] 1.2 Drugs: Guhong Injection (Arbela Medicine (China) Co., Ltd.); Sodium thiopental, anesthesia drug (Shanghai New Asia Pharmaceutical Co., Ltd.) is prepared into a 2% solution with normal saline for intraperitoneal injection during use, Penicillin Sodium (Harbin General Pharmaceutical Factory).

[0019] 2 Experimental methods

[0020] 2.1 Animal modeling and grouping: After the above 28 rabbits were adaptively fed for 3 days, they were anesthetized by intraperitoneal injection of 2% thiopental sodium 40 mg / kg. A longitudinal incision was made in the middle of the radius to expose the middle of the radius, and the radius was sawed into a standard transverse fracture with a bone defect o...

experiment example 2

[0040] Observation of curative effect of a pharmaceutical composition containing acetylglutamine and safflower in surgical wound healing and recovery.

[0041] 1 Clinical data: 102 patients in this group, 42 males and 60 females; 60 cases of neck incision, 30 cases of abdominal incision, 12 cases of back incision, 80 cases of first-class incision, 22 cases of second-class incision.

[0042] 2. Treatment method: Guhong injection (Albella Pharmaceutical (China) Co., Ltd.) intravenous infusion, 5ml-20ml at a time, diluted with 5% or 10% glucose injection 250ml-500ml and slowly instilled, once a day , 10-15 days for a course of treatment, with the patient's original routine antibiotic treatment.

[0043]3. Results: 78 cases of first-class incisions healed within 5 days, with a healing rate of 97.5%; 18 cases of second-class incisions healed within 5 days, with a healing rate of 81.8%, and 6 cases of delayed healing, of which 1 case had incision cracks due to excessive tension. Op...

experiment example 3

[0046] 10 Cases of Delayed Incision Healing Treated by Composition Containing Acetylglutamine and Safflower

[0047] 1 clinical data

[0048] 1.1 General information: All 10 patients in this group were female, aged 23 to 47 years, with an average age of 29 years. Among them, there were 7 cases of abdominal incision and 3 cases of perineal incision. The course of treatment is 16-36 days. 8 cases were complicated with postoperative infection, 6 cases had nonabsorbable knots in the infected incision, and 1 case reached the peritoneum.

[0049] 1.2 Clinical manifestations: local redness, swelling, induration, increased secretions, pus and scab, and dehiscence of the incision. Body temperature ranged from 37.8 to 38.5°C, with an average of 38.1°C. The largest wound is 5.6cm×3.0cm, and the smallest is 1.5cm×0.8cm. All were treated by local dressing change and application of antibiotics. Wound healing is slow, so use this method for treatment.

[0050] 1.3 Treatment method: Gu...

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PUM

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Abstract

The invention discloses the use of pharmaceutical composition containing aceglutamide and safflower extract in preparing medicament for tissue damage assimilation and recovery, wherein animal and human body clinical experiments show that the composition can be used for preparing medicament for promoting assimilation and recovery of bone fracture injury, surgical operation wound and neurotrauma.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to the application of a pharmaceutical composition in the preparation of medicines for promoting tissue injury healing and recovery. Background technique [0002] The patent document CN20040086213 discloses that safflower and acetylglutamine are combined according to a specific ratio, and the safflower extract is further extracted from safflower to prepare the safflower extract and the available drug is prepared with acetylglutamine for clinical application; CN20040086213 documents mainly mention The invention has the functions of promoting blood circulation and removing blood stasis, improving brain metabolism and brain function, and can be used as a medicine for treating obliterative cerebrovascular diseases, hepatic coma, hemiplegia, neurosurgery and other diseases caused by coma, paralysis, mental decline, and memory impairment. Application; It can also be us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61P19/08A61P17/00A61P25/00A61K31/198
Inventor 张玉梅
Owner 通化谷红制药有限公司
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