Crystal form of pyritinol maleate and preparation method thereof
A technology of acid pyrithione and maleic acid, applied in the field of medicine, can solve problems such as the lack of research reports on the crystal form of pyrithione maleate
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Embodiment 1
[0028] Dissolve 3.8g of maleic acid in 100ml of ethanol, heat up to 60°C to dissolve, add 5.0g of pyrithione, stir to dissolve, react for 1 hour, cool and crystallize, filter, and dry the solid under reduced pressure at 50°C to obtain White crystalline solid pyrithione maleate crystal form A4.9g. X-ray powder diffraction analysis, such as figure 1 , and its 2θ values are shown in the table below.
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Embodiment 2
[0033] Dissolve 3.8g of maleic acid in 100ml of acetone, heat up to 45°C to dissolve, add 5.0g of pyrithione, stir to dissolve, react for 1.5 hours, cool and crystallize, filter, and dry the solid under reduced pressure at 50°C to obtain White crystalline solid 5.2g. X-ray powder diffraction of the dry product shows pyrithione maleate as crystalline form A.
Embodiment 3
[0035] Dissolve 3.8g of maleic acid in 100ml of isopropanol, heat up to 60°C to dissolve, add 5.0g of pyrithione, stir to dissolve, react for 2 hours, cool and crystallize, filter, and dry the solid under reduced pressure at 50°C , to obtain 5.1 g of white crystalline solid. X-ray powder diffraction of the dry product shows pyrithione maleate as crystalline form A.
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