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Medicinal composition containing carthamin yellow and its preparation process and usage

A technology of safflower yellow pigment and composition, which is applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of insufficient treatment effect, time-consuming, and complicated treatment of cardiovascular and cerebrovascular diseases, and achieve the ability to maintain nerve stress and clinical Excellent curative effect and effect of improving microcirculation

Inactive Publication Date: 2006-05-10
阿尔贝拉医药控股(通化)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in terms of curative effect, the "safflower patent" still has insufficient therapeutic effect on cardiovascular and cerebrovascular diseases; in terms of technology, the "safflower patent" uses alcohol precipitation to process the safflower extract, which is complicated and time-consuming

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1-pharmaceutical composition

[0025] Add 30 times the volume (W / V) of 15% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 megahertz and a power of 12000 watts, extract 5 times at 70°C for 50 minutes each time, and combine the extracts. Add 30% acetone (V / V) and 0.3% crystallization aid caffeine (W / V, a reagent for assisting crystallization) to the extract, and let it stand for 36 hours to precipitate crystals that are safflower yellow.

[0026] According to the weight of acetylglutamine being 15 times of safflower yellow pigment, the pharmaceutical composition is obtained.

Embodiment 2

[0027] The preparation of embodiment 2-pharmaceutical composition

[0028] Add 50 times the volume of 30% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times at 70 ° C, 50 minutes each time, combine the extracts, add 30% acetone (V / V), 0.3% crystallization aid triethanolamine (W / V, a reagent for assisting crystallization and precipitation), let it stand for 36 hours, and the precipitated crystal is safflower yellow.

[0029] According to the ratio of the weight of acetylglutamine to 18 times of safflower yellow pigment, the pharmaceutical composition is obtained.

Embodiment 3

[0030] The preparation of embodiment 3-pharmaceutical composition

[0031] Add 100 times the volume (W / V) of 45% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times at 70 ° C, each time for 50 minutes, and combine the extracts. Add 30% acetone (V / V) and 0.3% crystallization aid copuline (W / V, a reagent for assisting crystallization) to the extract, and let it stand for 36 hours to precipitate crystals that are safflower yellow.

[0032] According to the ratio of the weight of acetylglutamine to 18 times of safflower yellow pigment, the pharmaceutical composition is obtained.

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PUM

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Abstract

The invention provides a medicinal composition containing carthamus tinctorius yellow color, which comprises aceglutamide and carthamus tinctorius yellow color by a predetermined proportion, and can be used for preparing medicament for the treatment of cerebrovascular diseases, hepatic coma, hemiplegia, paralysis, memory obstacle, coronary disease and angiitis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a novel pharmaceutical composition which can be prepared from acetylglutamine and safflower yellow pigment, safflower extracting effective parts and acetylglutamine, its preparation method and its It is used in the treatment of obliterative cerebrovascular disease, hepatic coma, hemiplegia, neurosurgery and other diseases caused by coma, paralysis, mental decline, and memory impairment. Background technique [0002] Acetylglutamine is N 2 -Acetyl-L-glutamine (C 7 h 12 N 2 o 4 ), which is a white crystalline powder, is often used clinically as a drug for improving brain function. The drug can pass through the blood-cerebrospinal fluid barrier, and after passing through the blood-cerebrospinal fluid barrier, it can be decomposed into glutamic acid and gamma-aminobutyric acid (GABA) to play a role. Glutamic acid participates in the information transmission of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/08A61K9/14A61K9/16A61K9/20A61K9/48A61P9/10A61P9/14A61P25/00
Inventor 张玉梅
Owner 阿尔贝拉医药控股(通化)有限公司
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