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Medicinal composition for treating and improving brain function, its preparation method and application

A technology for improving brain function and composition, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as low ganglioside content

Active Publication Date: 2005-10-26
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The contents of gangliosides in the currently disclosed brain extracts are all low, and although there are also public reports of gangliosides as components of the composition, and pharmaceutical compositions that work synergistically with other components, there is still no There are related reports that it plays a synergistic role with other animal tissues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] step 1):

[0093] Take 10kg of fresh rabbit muscle, add 10L water to homogenate, freeze after homogenization, freeze and thaw twice, heat at 60°C after thawing, keep warm for 20 minutes, and centrifuge after cooling down, the centrifugation condition is 4000 rpm, and the centrifugation time is 20 minutes , retain the supernatant, filter the supernatant to obtain the filtrate; add trypsin to the filtrate and heat-preserve for hydrolysis, the trypsin concentration is 0.2%, the hydrolysis conditions are pH=7.8, heat preservation at 37°C, and the heat preservation time is 2 hours; after enzymolysis , the pH value of the enzymolysis solution was adjusted to 3.8, heated to 80°C, kept for 20 minutes, and then centrifuged after cooling down, the centrifugation condition was 4000 rpm, and the centrifugation time was 20 minutes, the supernatant was retained, and the supernatant was filtered to obtain the filtrate.

[0094] Adjust the pH value of the filtrate to 6.8, freeze, and c...

Embodiment 2

[0104] step 1):

[0105] Take 10kg of fresh deer muscle, add 16L water to homogenate, freeze after homogenization, freeze and thaw once, heat at 70°C after thawing, keep warm for 25 minutes, and centrifuge after cooling down, the centrifugation condition is 3500 rpm, and the centrifugation time is 30 minutes , retain the supernatant, filter the supernatant to obtain the filtrate; add trypsin to the filtrate and heat-preserve for hydrolysis, the trypsin concentration is 0.8%, the hydrolysis conditions are pH=8.2, heat preservation at 45°C, and the heat preservation time is 3 hours; after enzymolysis , the pH value of the enzymolysis solution was adjusted to 4.1, heated to 80°C, kept for 15 minutes, and then centrifuged after cooling down, the centrifugation condition was 4000 rpm, and the centrifugation time was 30 minutes, the supernatant was retained, and the supernatant was filtered to obtain the filtrate.

[0106] Adjust the pH value of the filtrate to 7.1, freeze, and cent...

Embodiment 3

[0115] step 1):

[0116]Take 10kg of fresh rabbit muscle, add 25L water to homogenate, freeze after homogenization, freeze and thaw 3 times, heat at 65°C after thawing, keep warm for 25 minutes, and centrifuge after cooling down. The centrifugation condition is 3800 rpm, and the centrifugation time is 30 minutes. Retain the supernatant, filter the supernatant to obtain the filtrate; add trypsin to the filtrate for heat preservation and hydrolysis, the concentration of trypsin is 0.2%, the hydrolysis condition is pH8.4, heat preservation at 42°C, and heat preservation time is 1.5 hours; after enzymolysis, Adjust the pH value of the enzymolysis solution to 4.0, heat to 85°C, keep for 20 minutes, and then centrifuge after cooling down, the centrifugation condition is 4000 rpm, and the centrifugation time is 20 minutes, retain the supernatant, and filter the supernatant to obtain the filtrate.

[0117] Adjust the pH value of the filtrate to 7.4, heat it to 85°C, keep it for 20 min...

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PUM

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Abstract

A medicinal composition for preparing the medicine to improve the cerebral function contains proportionally the active polypeptide, amino acid and nucleic acid, which are extracted from the muscle tissue of mammal and ganglioside extracted from the cerebral tissue of mammal. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for treating brain function improvement, its preparation method and its application, in particular, it relates to a kind of active polypeptide, amino acid, nucleic acid extracted from the muscle tissue of mammals other than humans, and A pharmaceutical composition of gangliosides extracted from the brain tissue of mammals other than humans, a preparation method thereof, and a pharmaceutical application thereof in the preparation and treatment of dysfunction caused by brain diseases. Background technique [0002] Gangliosides are sialic acid-containing glycosphingolipids, one or more of which terminal sugar groups are N-acetylneuric acid, sialic acid. The membrane lipids of gray matter contain more than 6% gangliosides, which play an important role in nerve conduction. [0003] The clinical medicinal value of gangliosides are: for the functional recovery of central nervous system structural ...

Claims

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Application Information

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IPC IPC(8): A61K35/30A61K35/34
Inventor 杨尚华
Owner JILIN SIHUAN PHARM CO LTD
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