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Concentrated clear solution contg. biocefalin as brain metabolism improving medicine for intravenous injection after diluting it

A technology of pyrithione and clarification, which is applied in the field of medication for improving brain metabolism, can solve problems such as cumbersome operation, high energy consumption, and long preparation cycle, and achieve the effects of overcoming lengthy operation process, reducing operation steps, and avoiding damage

Inactive Publication Date: 2003-03-12
SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

The powder for injection can be prepared by using the freeze-dried powder injection process, or it can be directly packed into small-volume bottles with sterile raw material powder. The consumption is high, and the powder injection is easy to agglomerate after long-term storage. It is not easy to dissolve or not completely dissolved during use, resulting in unclear liquid medicine. The insoluble particles exceed the requirements of the Pharmacopoeia. Such as pulmonary granuloma, microvascular embolism, such as the direct cause of cerebral thrombosis, pulmonary embolism, myocardial infarction, etc.

Method used

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Embodiment Construction

[0007] The present invention relates to a concentrated clear solution containing pyrithione for improving brain metabolism after dilution for intravenous injection, wherein the active compound is salt pyrithione, the English name of pyrithione is Pyritinol; the common activity The chemical name of compound pyrithione hydrochloride is 3,3-(dithiomethylene) bis(5-hydroxy-6-methyl-pyridine) dihydrochloride monohydrate, in addition, pyrithione sulfate can also be used Thiol, pyrithione acetate and other salts such as pyrithione are used as active compounds.

[0008] The use of mixed solvents and co-solvents to increase the solubility of active compounds is the key to the preparation of concentrated clear solutions. Pyritinol is easily soluble in water and slightly soluble in ethanol in the form of its hydrochloride. In order to meet the clinical dosage, the content of the active compound pyrithione hydrochloride in the unit preparation should reach 0.1-0.2 grams. However, the sal...

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PUM

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Abstract

A concentrated clear solution used for intravenous injection after diluted contains cervitalin for improving cerebral metabolism, the mixture of alcohol and glycerine or propanediol, and additive.

Description

technical field [0001] The invention relates to a medicine for improving brain metabolism. Background technique [0002] In the prior art, pyrithione is used clinically in the form of its hydrochloride according to the preparation process of sterile injection powder, and is dissolved in water for injection before use. The powder for injection can be prepared by using the freeze-dried powder injection process, or it can be directly packed into small-volume bottles with sterile raw material powder. The consumption is high, and the powder injection is easy to agglomerate after long-term storage. It is not easy to dissolve or not completely dissolved during use, resulting in unclear liquid medicine. The insoluble particles exceed the requirements of the Pharmacopoeia. Such as pulmonary granuloma, microvascular embolism, such as cerebral thrombosis, pulmonary embolism, myocardial infarction and other direct causes. Contents of the invention [0003] The object of the present ...

Claims

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Application Information

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IPC IPC(8): A61K31/444A61P9/10A61P43/00
Inventor 罗明生阎政罗非非王金陵刘志祥刘雍杨启有臧建英
Owner SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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