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Traditional Chinese medicine formula for treating Alzheimer's disease and preparation method of compound preparation of traditional Chinese medicine formula

A technology for Alzheimer's disease and compound preparations, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, and can solve problems such as single-target, ineffective drug effects, and lack of immune regulation. To achieve the effect of improving the therapeutic effect and improving the cognitive function of the brain

Active Publication Date: 2021-09-21
中山创天生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the problems of the existing drugs for treating Alzheimer's disease, such as ineffectiveness, many side effects, only single target, lack of immune regulation, etc., to provide a drug with significant effect, short course of treatment, A fast-acting, safe and non-toxic traditional Chinese medicine prescription for the treatment of Alzheimer's disease

Method used

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  • Traditional Chinese medicine formula for treating Alzheimer's disease and preparation method of compound preparation of traditional Chinese medicine formula
  • Traditional Chinese medicine formula for treating Alzheimer's disease and preparation method of compound preparation of traditional Chinese medicine formula
  • Traditional Chinese medicine formula for treating Alzheimer's disease and preparation method of compound preparation of traditional Chinese medicine formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The parts by weight of each component are: 48 parts of Dendrobium nobile, 18 parts of Radix Astragali, 18 parts of Salvia Miltiorrhiza, 7 parts of Polygonatum, 7 parts of Rhizoma Chuanxiong, and 2 parts of Licorice. Among them, Dendrobium nobile is composed of stems of Dendrobium nobile and flowers of Dendrobium nobile in a weight ratio of 5.5:1.5.

[0047] The steps of making the above components into granular granules are:

[0048] 1) making standard Chinese medicine decoction pieces with Dendrobium nobile, Radix Astragali, Salvia miltiorrhiza, Polygonatum, Rhizoma Chuanxiong, and licorice;

[0049] 2) Preparation of licorice extract: crush licorice into powder, add water at a low temperature of 0-10°C, rotate at a speed of 15000-30000 rpm, 50-60 Hz ultrasonic for 30-60 minutes, centrifuge at a high speed, separate the supernatant and precipitate, supernatant The solution was kept for later use, and ethanol was added to the precipitate, low-temperature ultrasonicatio...

Embodiment 2

[0056] Dendrobium nobile 40 parts, Astragalus 20 parts, Salvia miltiorrhiza 20 parts, Polygonatum 8 parts, Rhizoma Chuanxiong 8 parts, Licorice 4 parts.

[0057] Among them, Dendrobium nobile is composed of stems of Dendrobium nobile and flowers of Dendrobium nobile in a weight ratio of 6.5:2.0.

[0058] The steps of making the above components into granular granules are:

[0059] 1) making standard Chinese medicine decoction pieces with Dendrobium nobile, Radix Astragali, Salvia miltiorrhiza, Polygonatum, Rhizoma Chuanxiong, and licorice;

[0060] 2) Preparation of licorice extract: crush licorice into powder, add water and ultrasonic for 30-60 minutes at low temperature, centrifuge at high speed, separate the supernatant and precipitate, save the supernatant for later use, add ethanol to the precipitate, perform low-temperature ultrasonication for 15-30 minutes, pump Filter, wash the filter residue with ethanol for 3 to 5 times, collect the filter residue and filtrate respe...

Embodiment 3

[0067] The parts by weight of each component are: 50 parts of Dendrobium nobile, 15 parts of Astragalus membranaceus, 15 parts of Salvia miltiorrhiza, 4 parts of Polygonatum, 4 parts of Chuanxiong, and 2 parts of licorice. The weight ratio is 5.0:1.0 composition.

[0068] The steps of making the above components into decoction are:

[0069] Mix each group of raw materials in a decoction device according to the weight ratio of total raw materials: water 1.0:3.0, boil for 30 minutes for the first time, filter with a 2.0 μm filter bag, and keep the filtrate for later use; continue to add water to boil the dregs after the first boiling and filtering For 60 minutes, filter with a 1.5μm filter bag, and keep the filtrate for later use; then add water to boil the dregs of the second boiling filter for 90 minutes, filter with a 1.0μm filter bag, and keep the filtrate for later use; finally, combine the three filtrates and put them in an airtight container for sterilization Fill it, st...

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Abstract

The invention discloses a traditional Chinese medicine formula for treating Alzheimer's disease and a preparation method of a compound preparation of the traditional Chinese medicine formula. The traditional Chinese medicine formula consists of the following components in parts by weight: 40-50 parts of dendrobium nobile, 15-20 parts of astragalus membranaceus, 15-20 parts of salvia miltiorrhiza, 4-8 parts of rhizoma polygonati, 4-8 parts of ligusticum wallichii and 2-4 parts of liquorice, wherein the dendrobium nobile consists of dendrobium nobile stems and dendrobium nobile flowers in a weight ratio of (5.0-6.5): (1.0-2.0). The dendrobium nobile serves as a monarch drug, the radix astragali and the radix salviae miltiorrhizae serve as ministerial drugs, the rhizoma chuanxiong and the rhizoma polygonati serve as adjuvant drugs, the liquorice serves as a conductant drug, the brain cognitive function is improved by means of neurotransmitters, cerebrovascular expansion, brain metabolism promoting drugs and the like, and the development process of the Alzheimer's disease is prevented. According to the compound traditional Chinese medicine for treating the Alzheimer's disease, the treatment effect of the medicine on the Alzheimer's disease is improved through the specific targeting effect and the mutual cross function of the components.

Description

technical field [0001] The invention relates to a traditional Chinese medicine prescription for treating Alzheimer's disease and a preparation method thereof, belonging to the technical field of modern traditional Chinese medicine. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease commonly seen in the elderly. Progressive cognitive impairment and memory loss are the main clinical symptoms. [0003] With the increase in life expectancy of the current social population, the incidence of AD in the elderly population has shown a significant upward trend. But so far there is no clear pathogenesis and effective treatment. [0004] The existing drugs for the treatment of mild to moderate Alzheimer's disease are donepezil (Aricept) from Pfizer and Eisai, and rivastigmine (Exelon) from Novartis. , Johnson & Johnson's galantamine (Reminyl), Lundbeck's memantine (Ebixa). But the side effects of this western medicine are very obvious. Such as nau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P25/28
CPCA61K36/8984A61K36/481A61K36/537A61K36/8969A61K36/236A61K36/484A61P25/28A61K2236/331A61K2236/53A61K2236/333A61K2236/39A61K2236/51A61K2236/37A61K2300/00
Inventor 孙勉凌仕信
Owner 中山创天生物科技有限公司
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