Extracellular adhesive proteins

a technology of adhesive proteins and proteins, applied in the field of extracellular adhesive proteins, can solve the problems of early embryonic lethality in mice, and achieve the effects of increasing the solubility of compounds, increasing the viscosity of suspensions, and high concentration of solutions

a technology of adhesive proteins and proteins, applied in the field of extracellular adhesive proteins, can solve the problems of early embryonic lethality in mice, and achieve the effects of increasing the solubility of compounds, increasing the viscosity of suspensions, and high concentration of solutions

US20010010913A1Inactive Publication Date: 2001-08-02INCYTE PHARMA INC
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  • Extracellular adhesive proteins
  • Extracellular adhesive proteins
  • Extracellular adhesive proteins

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I. Construction of CDNA Libraries

[0180] The BONTNOT01 cDNA library was constructed using RNA isolated from tibial periosteum removed from a 20-year-old Caucasian male during a hemipelvectomy with amputation above the knee. Pathology for the associated tumor tissue indicated partially necrotic and cystic osteoblastic grade 3 osteosarcoma, post-chemotherapy. Family history included osteogenesis imperfecta, closed fracture, and type II diabetes.

[0181] The LUNGNOT23 cDNA library was constructed using RNA isolated from left lobe lung tissue removed from a 58-year-old Caucasian male. Pathology for the associated tumor tissue indicated metastatic grade 3 (of 4) osteosarcoma. Patient history included soft tissue cancer, secondary cancer of the lung, prostate cancer, and an acute duodenal ulcer with hemorrhage. Family history included prostate cancer, breast cancer, and acute leukemia.

[0182] For construction of the BONTNOT01 and LUNGNOT23 cDNA libraries, frozen tissue from each of the above ...

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PUM

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Abstract

The invention provides human extracellular adhesive proteins (EXADH) and polynucleotides which identify and encode EXADH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of EXADH.

Description

[0001] This application is a divisional application of U.S. application Ser. Number 09 / 131,648, filed Aug. 10, 1998, entitled EXTRACELLULAR ADHESIVE PROTEINS, all of which applications and patents are hereby incorporated herein by reference.[0002] This invention relates to nucleic acid and amino acid sequences of extracellular adhesive proteins and to the use of these sequences in the diagnosis, treatment, and prevention of cancer, inmmune disorders, and developmental disorders.[0003] The surface of a cell is rich in transmembrane proteoglycans, glycoproteins, glycolipids, and receptors. These macromolecules mediate adhesion with other cells and with components of the extracellular matrix (ECM). The ECM is comprised of diverse glycoproteins, polysaccharides, and carbohydrate-binding proteins which are secreted from the cell and assembled into an organized meshwork in close association with the cell surface. The interaction of the cell with the surrounding matrix profoundly influence...

Claims

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Application Information

Patent Timeline
02 Aug 2001
Publication
US20010010913A1
IPC
G01N33/50; A61K38/00; A61K45/00; A61P1/04; A61P5/00; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P15/00; A61P17/06; A61P21/04; A61P25/08; A61P25/14; A61P25/18; A61P27/06; A61P27/12; A61P27/16; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P37/08; A61P43/00; C07K14/705; C07K14/78; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; G01N37/00
CPC
A61K38/00; C07K14/705; A61P1/04; A61P5/00; A61P7/06; A61P9/00; A61P9/10; A61P11/00
Inventors
HILLMAN, JENNIFER L.; YUE, HENRY