Extracellular adhesive proteins

a technology of adhesive proteins and proteins, applied in the field of extracellular adhesive proteins, can solve the problems of early embryonic lethality in mice, and achieve the effects of increasing the solubility of compounds, increasing the viscosity of suspensions, and high concentration of solutions
US20010010913A1Inactive Publication Date: 2001-08-02INCYTE PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INCYTE PHARMA INC
Publication Date
2001-08-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides human extracellular adhesive proteins (EXADH) and polynucleotides which identify and encode EXADH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of EXADH.
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Description

[0001] This application is a divisional application of U.S. application Ser. Number 09 / 131,648, filed Aug. 10, 1998, entitled EXTRACELLULAR ADHESIVE PROTEINS, all of which applications and patents are hereby incorporated herein by reference.

[0002] This invention relates to nucleic acid and amino acid sequences of extracellular adhesive proteins and to the use of these sequences in the diagnosis, treatment, and prevention of cancer, inmmune disorders, and developmental disorders.

[0003] The surface of a cell is rich in transmembrane proteoglycans, glycoproteins, glycolipids, and receptors. These macromolecules mediate adhesion with other cells and with components of the extracellular matrix (ECM). The ECM is comprised of diverse glycoproteins, polysaccharides, and carbohydrate-binding proteins which are secreted from the cell and assembled into an organized meshwork in close association with the cell surface. The interaction of the cell with the surrounding matrix profoundly influence...

Claims

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