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Medicinal composition containing safflower total flavone and its preparation process and usage

The technology of total flavonoids and composition of safflower is applied in the field of medicine, which can solve the problems of insufficient treatment effect of cardiovascular and cerebrovascular diseases, lack of clinical use, complicated and time-consuming processing, etc., so as to maintain nerve stress ability, improve microcirculation, and achieve finished products. rate increase effect

Active Publication Date: 2006-05-10
通化谷红制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in terms of curative effect, the "safflower patent" still has insufficient therapeutic effect on cardiovascular and cerebrovascular diseases; there are still clinical applications that have not been developed; in terms of technology, the "safflower patent" uses alcohol precipitation to treat the safflower extract , there are many impurities in the product, the processing is complicated and time-consuming, and the product yield is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1-pharmaceutical composition

[0025] Add 30 times the volume of 15% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times under the condition of 70 ° C, 50 minutes each time, combine the extracts, and use NaOH or Adjust the pH to 7-8 with hydrochloric acid, add a chitosan solution with a concentration of 0.5%, stir, let stand for 1-2 hours, filter, and dry the filtrate under reduced pressure at 65°C to an extract with a specific gravity of 1.25-1.30, namely For the total flavonoids of safflower. The total flavonoids are stored under refrigeration, and the temperature of refrigeration is controlled between 0 and 4°C. Proportioning is carried out according to the weight of acetylglutamine being 15 times of total flavonoids of safflower.

Embodiment 2

[0026] The preparation of embodiment 2-pharmaceutical composition

[0027]Add 50 times the volume of 30% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times under the condition of 70 ° C, 50 minutes each time, combine the extracts, and use NaOH or Adjust the pH to 7-8 with hydrochloric acid, add a chitosan solution with a concentration of 0.5%, stir, let stand for 1-2 hours, filter, and dry the filtrate under reduced pressure at 65°C to an extract with a specific gravity of 1.20-1.50, namely For the total flavonoids of safflower. The total flavonoids are stored under refrigeration, and the temperature of refrigeration is controlled between 0 and 4°C. According to the weight of acetylglutamine being 18 times of the total flavonoids of safflower, it is prepared.

Embodiment 3

[0028] The preparation of embodiment 3-pharmaceutical composition

[0029] Add 200 times the volume of 45% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times under the condition of 70 ° C, 50 minutes each time, combine the extracts, and use NaOH or Adjust the pH to 7-8 with hydrochloric acid, add a chitosan solution with a concentration of 0.5%, stir, let stand for 1-2 hours, filter, and dry the filtrate under reduced pressure at 65°C to an extract with a specific gravity of 1.25-1.30, namely For the total flavonoids of safflower. The total flavonoids are stored under refrigeration, and the temperature of refrigeration is controlled between 0 and 4°C. According to the weight of acetylglutamine being 18 times of the total flavonoids of safflower, it is prepared.

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PUM

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Abstract

The invention discloses a medicinal composition containing total safflower flavones for treating cardiac and cerebral vascular diseases, which comprises total safflower flavones and aceglutamide by a predetermined proportion.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition composed of safflower total flavonoids and acetylglutamine, safflower extracting effective parts and acetylglutamine, its preparation method and its application in the treatment of occlusive cerebrovascular Diseases, hepatic coma, hemiplegia, neurosurgery and other coma, paralysis and mental retardation, memory impairment, epilepsy and other diseases. Background technique [0002] Safflower is the dry flower of safflower (Carthamus tinctorins L), which is warm in nature and pungent in taste. Can promote blood circulation and stimulate menstruation, dissipate blood stasis and relieve pain. For irregular menstruation, dysmenorrhea and amenorrhea bruises. It has a certain curative effect on coronary heart disease, vascular embolism disease, and infectious hepatitis. Safflower contains Flavonols, Chalcones, Alkane diols, Serotonin derivativ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K36/286A61P9/10A61P25/00
Inventor 张玉梅
Owner 通化谷红制药有限公司
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