Pharmaceutical composition containing vinpocetine, preparation method and application thereof

A technology of vinpocetine and composition, which is applied in the formulation, preparation process and application field of small-capacity preparations, and can solve problems such as imperfect raw materials and preparation processes, discoloration, and related substances exceeding the standard

Active Publication Date: 2010-11-24
北京爱力佳医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, my country has already produced small volume injections of this type, but due to the imperfection of raw materials and preparation technology, a series of problems such as discoloration and related substances exceeding the standard often occur.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Vinpocetine 20g VC 2g

[0069] Mannitol 100g Sodium metabisulfite 2g

[0070] Propylene Glycol 20g Citric Acid 20g

[0071] Appropriate amount of sodium hydroxide

[0072]

[0073] Add water for injection to 2000ml

[0074] Process: Use water for injection to prepare an appropriate amount of citric acid solution with a pH value of 2.9, measure 1400ml of the prepared citric acid solution and add it to the liquid preparation tank, add 20g of vinpocetine raw material, stir to dissolve, then add 2g of VC, 2g of coke Sodium sulfite, 100g mannitol, 20g propylene glycol, stirred to dissolve, supplemented with water for injection to 1800ml, adjusted the Ph value to 3.7 with citric acid solution and sodium hydroxide solution, supplemented with water for injection to 2000ml, added 0.3% activated carbon for adsorption for 30 minutes, filtered and Fill it, and sterilize it at 121 degrees...

Embodiment 2

[0076] Vinpocetine 25g VC 2g

[0077] Sorbitol 100g Sodium metabisulfite 2g

[0078] Propylene Glycol 20g Tartaric Acid 50g

[0079] Appropriate amount of sodium hydroxide

[0080]

[0081] Add water for injection to 2000ml

[0082] Process: Use water for injection to prepare an appropriate amount of tartaric acid solution with a pH value of 2.9, measure 1400ml of the prepared tartaric acid solution and add it to the liquid mixing tank, add 20g of vinpocetine raw material, stir to dissolve, then add 2g of VC, 2g of sodium metabisulfite and 100g sorbitol, 20g propylene glycol, stir to dissolve, replenish water for injection to 1800ml, adjust pH to 3.7 with tartaric acid solution and sodium hydroxide solution, replenish water for injection to 2000ml, add 0.3% activated carbon for 30 minutes, filter and fill, 121 Sterilize for 8 minutes, that is. (Note: During the preparation and filling ...

Embodiment 3

[0084] Vinpocetine 30g VC 1g

[0085] Mannitol 150g Sodium metabisulfite 3g

[0086] Propylene Glycol 40g Citric Acid 70g

[0087] Appropriate amount of sodium hydroxide

[0088]

[0089] Add water for injection to 2000ml

[0090] Technological process is the same with embodiment 1.

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PUM

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Abstract

The invention provides a pharmaceutical composition containing vinpocetine, a preparation method and an application of the pharmaceutical composition. The composition comprises the following components in parts by weight: 1 part of vinpocetine, 0.5-3 parts of cosolvent, 0.02-0.8 part of antioxidant, 2-20 parts of stabilizer, 1-5 parts of vascular regulator and a proper amount of Ph regulator. The composition is mainly used for treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to pharmaceutical preparations in the field of medicine, in particular to the formulation, preparation process and application of a small-capacity preparation of an injection composition containing vinpocetine. Background technique [0002] Vinpocetine (Vinpocetine) is a natural medicine obtained from periwinkle, which belongs to indole alkaloids. For a long time, Vinpocetine has been widely used in the treatment and prevention of ischemic cerebrovascular diseases. Vinca (Vincamajor, Vincaminor) is a common evergreen ground cover plant similar to vines. It is distributed in central and southern Europe and other regions. It has been used as a medicinal plant for nearly 2,000 years. It is used by folks to cheer up the spirit and restore fatigue, especially aging. Related similar symptoms are also used as astringents and the like. Vinpocetine was first successfully developed by Gedeon Richter Company in Hungary, and later authorized...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4375A61K47/12A61K47/22A61K47/02A61K47/10A61P9/10A61P9/12
Inventor 袁璐
Owner 北京爱力佳医药科技有限公司
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