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Vinpocetine oral self-micro-emulsification medicine-releasing system and preparation method thereof

A vinpocetine self-microemulsification technology, applied in the field of medicine, can solve the problems of low bioavailability, frequent administration, and single dosage form

Inactive Publication Date: 2008-01-16
华中科技大学同济医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Vinpocetine's remarkable therapeutic effects and low toxicity and side effects have been clinically affirmed, but the bioavailability is low, the frequency of administration is high, and the dosage form is single. secondary development

Method used

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  • Vinpocetine oral self-micro-emulsification medicine-releasing system and preparation method thereof
  • Vinpocetine oral self-micro-emulsification medicine-releasing system and preparation method thereof
  • Vinpocetine oral self-micro-emulsification medicine-releasing system and preparation method thereof

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Experimental program
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Embodiment 1

[0028] Prescription composition:

[0029] Vinpocetine 5g

[0030] GTCC 80g

[0031] Oleic acid 20g

[0032] Cremophor EL 80g

[0033] Transcutol P 20g

[0034]

[0035] Made 1000 softgels in total

[0036] Preparation Process:

[0037]Weigh each adjuvant of prescription quantity, after stirring evenly, obtain uniform clear oily liquid, then add the medicine of prescription quantity under stirring at room temperature, mix well about 1h to make it fully dissolve, make soft capsule, obtain Vinpocetine self micro Emulsified soft capsules. Negatively charged vinpocetine oral self-microemulsifying concentrate (i.e. (-) VIN-SMEDDS, abbreviated as VIN-SMEDDS) can be obtained according to the above prescription, and positively charged vinpocetine can be obtained after adding 1% oleylamine Oral administration of self-microemulsifying concentrated solution (ie (+) VIN-SMEDDS) will further promote intestinal a...

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Abstract

The invention relates to a vinpocetine oral self-micro-emulsifying drug delivery system and the preparation method. The vinpocetine oral self-micro-emulsifying drug delivery system is composed of vinpocetine, fat phase, emulsifier and coemulsifier. The mass ratio percentage preferential scope of the ingredients is that the vinpocetine occupies 1-10 per cent, the fat phase occupies 20-60 per cent, the emulsifier occupies 25-70 per cent and the coemulsifier occupies 0-25 per cent. The vinpocetine oral self-micro-emulsifying drug delivery system can be spontaneously emulsified into micro-emulsion with 10-100 mm granule diameter after taken orally, promoting drug to be quickly absorbed. The drug delivery system has the advantages of improving the solubility of the vinpocetine in water, improving the availability of the vinpocetine and eliminating the influence of food to the absorption and bioavailability of the vinpocetine.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new oral drug delivery system for vinpocetine, specifically, an oral self-microemulsification drug delivery system for vinpocetine and a preparation method thereof. Background technique [0002] Vinpocetine (Vinpocetine) is a derivative of the indole alkaloid vincamine extracted from the plant Vinca oleander of the Apocynaceae family. It is a brain circulation metabolism improving agent, which can improve the blood circulation of the brain and promote the energy of the brain. Metabolism, has a good curative effect on the prevention and treatment of cerebral arteriosclerosis, sequelae of cerebral hemorrhage and hyperviscosity of hypertensive coronary heart disease, and can be used to improve brain function, enhance memory, improve mood, and improve aging hearing and vision Abnormal, delay brain aging, long-term application safety and high tolerance. [0003] Vinpocetine was succ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/48A61K9/08A61K31/4375A61P9/10A61P25/28A61P25/00
Inventor 李高陈鹰斯陆勤黄建耿
Owner 华中科技大学同济医学院
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