Medicament for treating cerebral blood-vessel dilate and preparation method thereof

A cerebrovascular and vinpocetine technology, applied in the field of pharmaceutical preparations, can solve problems such as poor water solubility, affecting drug absorption and bioavailability

Inactive Publication Date: 2011-07-06
长春海悦药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of vinpocetine is not good, and the clinical applicat

Method used

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  • Medicament for treating cerebral blood-vessel dilate and preparation method thereof
  • Medicament for treating cerebral blood-vessel dilate and preparation method thereof
  • Medicament for treating cerebral blood-vessel dilate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 (by 1000 bottles)

[0086] Take the raw and auxiliary materials by the following parts by weight:

[0087] 10 parts by weight of vinpocetine, 1 part by weight of vitamin C, 2 parts by weight of sodium metabisulfite, 200 parts by weight of mannitol, 100 parts by weight of sorbitol, and 4 parts by weight of tartaric acid.

[0088] Above-mentioned dosage form preparation method of the present invention is as follows:

[0089] 1. Take freshly prepared water for injection, boil it, wait until the temperature drops to 40°C, and set aside.

[0090] 2. Measure 1600ml of the above-mentioned water for injection, add vitamin C, stir to dissolve, slowly add vinpocetine, after dissolving, add sodium metabisulfite, sorbitol, mannitol, and tartaric acid to dissolve.

[0091] 3. Stir well, measure the pH value, adjust the pH value to 3.5 (3.0-4.0) with tartaric acid, add 0.03% (g / ml) needles, stir well with activated carbon, stir and absorb for 20 minutes, decarbonize an...

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Abstract

The invention relates to a medicament for treating cerebral blood-vessel dilate and a preparation method thereof, in particular relating to a vinpocetine freeze-dried preparation for treating cerebral blood-vessel dilate. The vinpocetine freeze-dried preparation is prepared from the following raw and auxiliary materials in parts by weight: 5 to 15 parts of the vinpocetine, 0.5 to 5 parts of vitamin C, 1 to 5 parts of sodium pyrosulfite, 100 to 300 parts of mannitol, 50 to 150 parts of sorbitol, and 1 to 10 parts of tartaric acid. The raw material medicaments and auxiliary materials are added according to the conventional method in the field to prepare a preparation for intravenous drip. The preparation has the characteristics of stable quality, safety and obvious curative effect.

Description

Technical field: [0001] The present invention relates to a kind of cerebrovascular dilatation drug and preparation method thereof, in particular to a vinpocetine freeze-dried preparation for cerebrovascular dilation, which is used for treating various acute and chronic cerebrovascular diseases and their sequelae; craniocerebral Restoration of brain function after surgery; coronary heart disease, arteriosclerosis, etc.; hearing loss, vertigo and tinnitus; fundus circulation disorder, retinopathy, etc. It belongs to the field of pharmaceutical preparations. Background technique: [0002] Cerebral arteriosclerosis is a part of systemic arteriosclerosis, and refers to chronic brain syndrome of chronic brain dysfunction caused by cerebral arteriosclerosis, arteriosclerosis, hyaline degeneration and other cerebral arterial wall degeneration. A large number of studies have confirmed that the incidence of cerebral arteriosclerosis is increasing year by year, and more than 90% of th...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/4375A61K47/22A61K47/26A61P9/10
Inventor 姜波董伟王世曼陈德峰王明明
Owner 长春海悦药业股份有限公司
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