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Medicament for treating cerebral blood-vessel dilate and preparation method thereof

A cerebrovascular and vinpocetine technology, applied in the field of pharmaceutical preparations, can solve problems such as poor water solubility, affecting drug absorption and bioavailability

Inactive Publication Date: 2011-07-06
长春海悦药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of vinpocetine is not good, and the clinical application is mainly oral administration, which affects drug absorption and bioavailability

Method used

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  • Medicament for treating cerebral blood-vessel dilate and preparation method thereof
  • Medicament for treating cerebral blood-vessel dilate and preparation method thereof
  • Medicament for treating cerebral blood-vessel dilate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 (by 1000 bottles)

[0086] Take the raw and auxiliary materials by the following parts by weight:

[0087] 10 parts by weight of vinpocetine, 1 part by weight of vitamin C, 2 parts by weight of sodium metabisulfite, 200 parts by weight of mannitol, 100 parts by weight of sorbitol, and 4 parts by weight of tartaric acid.

[0088] Above-mentioned dosage form preparation method of the present invention is as follows:

[0089] 1. Take freshly prepared water for injection, boil it, wait until the temperature drops to 40°C, and set aside.

[0090] 2. Measure 1600ml of the above-mentioned water for injection, add vitamin C, stir to dissolve, slowly add vinpocetine, after dissolving, add sodium metabisulfite, sorbitol, mannitol, and tartaric acid to dissolve.

[0091] 3. Stir well, measure the pH value, adjust the pH value to 3.5 (3.0-4.0) with tartaric acid, add 0.03% (g / ml) needles, stir well with activated carbon, stir and absorb for 20 minutes, decarbonize an...

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Abstract

The invention relates to a medicament for treating cerebral blood-vessel dilate and a preparation method thereof, in particular relating to a vinpocetine freeze-dried preparation for treating cerebral blood-vessel dilate. The vinpocetine freeze-dried preparation is prepared from the following raw and auxiliary materials in parts by weight: 5 to 15 parts of the vinpocetine, 0.5 to 5 parts of vitamin C, 1 to 5 parts of sodium pyrosulfite, 100 to 300 parts of mannitol, 50 to 150 parts of sorbitol, and 1 to 10 parts of tartaric acid. The raw material medicaments and auxiliary materials are added according to the conventional method in the field to prepare a preparation for intravenous drip. The preparation has the characteristics of stable quality, safety and obvious curative effect.

Description

Technical field: [0001] The present invention relates to a kind of cerebrovascular dilatation drug and preparation method thereof, in particular to a vinpocetine freeze-dried preparation for cerebrovascular dilation, which is used for treating various acute and chronic cerebrovascular diseases and their sequelae; craniocerebral Restoration of brain function after surgery; coronary heart disease, arteriosclerosis, etc.; hearing loss, vertigo and tinnitus; fundus circulation disorder, retinopathy, etc. It belongs to the field of pharmaceutical preparations. Background technique: [0002] Cerebral arteriosclerosis is a part of systemic arteriosclerosis, and refers to chronic brain syndrome of chronic brain dysfunction caused by cerebral arteriosclerosis, arteriosclerosis, hyaline degeneration and other cerebral arterial wall degeneration. A large number of studies have confirmed that the incidence of cerebral arteriosclerosis is increasing year by year, and more than 90% of th...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/4375A61K47/22A61K47/26A61P9/10
Inventor 姜波董伟王世曼陈德峰王明明
Owner 长春海悦药业股份有限公司
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