Preparation of oleanolic acid structure analogues and semisynthesis method of oleanolic acid

A technology with oleanolic acid and similar structure, which is applied in the field of chemical substances or pharmaceutical manufacturing, can solve problems such as low efficiency and low extraction yield, and achieves the effects of solving low efficiency, simple method and low extraction yield.
CN101974059AInactive Publication Date: 2011-02-16WUHAN JUHUI GREEN IND DEV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WUHAN JUHUI GREEN IND DEV
Publication Date
2011-02-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to preparation of oleanolic acid structure analogues and a semisynthesis method of oleanolic acid, which belongs to a manufacturing method of a chemical substance or medicament. The invention solves the problem that the traditional extraction and preparation of oleanolic acid has low efficiency due to the limit of the oleanolic acid content in plants, prepares oleanolic acid structure analogues contained in the plants by separation, and further realizes the semisynthesis of the oleanolic acid by using the oleanolic acid structure analogues as raw materials so as to solve the problem of low extraction yield in the prior art. In the method, leaves of olea europaea l. (an oleaceae plant) or fruits of ligustrum lucidum ait. are extracted and separated into two oleanolic acid structure analogues, and the two oleanolic acid structure analogues are used to carry out the semisynthesis of the oleanolic acid. The method comprises the steps of pretreatment, extraction, crude separation, purification and semisynthesis. Thus, the invention ensures the quality of the finished product, saves the production cost and improves the production efficiency.
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Description

technical field

[0001] The present invention belongs to the manufacture method of chemical substances or medicines, in particular to two kinds of olean fruit (olea europaea l.) leaves or privet (ligustrum lucidum ait.) fruit are used as raw materials after extraction and separation A structural analogue of fruit acid, and a method for semi-synthesizing oleanolic acid with the structural analogue as a raw material. Background technique

[0002] Oleanolic acid is a pentacyclic triterpenoid, which exists in many plants in the form of free body and glycoside. Oleanolic acid is white needle crystal; odorless, tasteless, soluble in methanol, ethanol, benzene, ether, acetone and chloroform, almost insoluble in water, unstable to acid and alkali. Oleanolic acid mainly has the effects of protecting the liver and reducing enzymes, promoting liver cell regeneration, anti-inflammation, strengthening the heart, diuresis, and anti-tumor. It also has the effects of lowering blood sugar, b...

Claims

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