75 results about "Chemical inhibition" patented technology

The invention provides a fire extinguishing agent. The fire extinguishing agent is prepared by evenly mixing 1-25 parts of hydrophilic solid powder and 100 parts of water or water solution, and then adding 0.001-2 parts of surfactant for evenly mixing; and then adding 2-100 parts of hydrophobic solid particles. The invention provides a preparation method of the fire extinguishing agent. Compared with the existing fire extinguishing agent, the fire extinguishing agent can simultaneously play stifling, cooling and chemical inhibition roles, and the fire extinguishing efficiency is high; according to the fire extinguishing agent, due to addition of the surfactant in the water phase, the dispersion of rotating speed in preparation process can be lowered, the dispersion time can be shortened, and the preparation efficiency can be improved; and with the fire extinguishing agent, the adhesion property of solid gas interface and liquid gas interface can be greatly improved, the usage amount for extinguishing fire can be greatly reduced, and the fire extinguishing property can be obviously improved.

The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells, comprising inhibiting the p53 function in the step of somatic cell nuclear reprogramming. The inhibition of p53 function is achieved by bringing a substance selected from the group consisting of (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors, into contact with a somatic cell, and the like. The present invention also provides an agent for improving the efficiency of establishment of iPS cells, the agent comprising an inhibitor of p53 function, particularly (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors. The present invention further provides a method of producing an iPS cell, comprising bringing a nuclear reprogramming substance and an inhibitor of p53 function into contact with a somatic cell.

Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A₂ enzymes (cPLA₂), more particularly including inhibitors of cytosolic phospholipase A₂ alpha enzymes (cPLA₂α). In some embodiments, the inhibitors have the Formula I:

wherein the constituent variables are as defined herein.

The invention relates to an organic acid compound-containing fire extinguishing composition, which contains an organic acid compound. The content of the organic acid compound is over 50(mass)%, preferably 70(mass)%-90(mass)%. Under high temperature, the organic acid compound can absorb heat and decompose to release a fire-extinguishing substance, which can react with one or several of the O., OH., H. free radicals necessary for a chain combustion reaction through a free radical, thus cutting off the chain combustion reaction. Also, the oxygen partial pressure can be reduced through a physical effect so as to suppress flames. Or a fire extinguishing effect can be realized by simultaneous physical and chemical inhibition together. At the same time, the fire extinguishing composition and a pyrotechnic agent can have a synergistic effect, thus further improving the fire extinguishing efficiency of a fire extinguishing agent and greatly shortening the effective fire extinguishing time.

The invention relates to a temperature-sensitive-type intelligent nano particles used in a drilling fluid and a preparation method thereof. In the invention, a silane coupling agent is used for performing ultrasound surface modification to nano SiO2 and a vinyl functional group is introduced. With the surface-modified nano SiO2, a temperature-sensitive-type monomer and a hydrophilic monomer are subjected to a polymerization reaction in a water medium with a co-solvent with addition of an initiator, wherein granularity distribution of the temperature-sensitive-type intelligent nano particles is D10 <= 100 nm, D 50 <= 165 nm and D90 <= 260 nm. When the temperature is higher than a sensitive value, the nano particles achieve double functions of both physical blocking and chemical inhibition, so that a continuous compact hydrophobic blocking layer is formed inside shale, thereby achieving effects of preventing and delaying pressure transmission and filtration invasion, and further enhancing stability of a shale well wall.

A system and method for quantifying opaque inhomogeneities within a fluid sample. The system uses an optical lens system to focus a light beam onto a stage where the sample is introduced. The light beam is directed onto the sample in a pattern such that the intensity of transmitted light is measured as a function of path length. A photo detector measures the transmitted light through the sample. Fluctuations in transmitted light intensity are then correlated with detection of opaque inclusions in the sample. The system also includes an automated program which utilizes these optical concentration measurements to determine the fouling potential of visbroken tars, and regulates the introduction of chemical inhibitors into a visbreaker unit to improve the yield of light streams and/or economic value of product.

The invention discloses a soilless cultivation medium and a preparation method of the soilless cultivation medium, relates to the soilless cultivation medium, and belongs to the technical field of agricultural cultivation. The soilless cultivation medium is characterized by comprising, by weight, 20-40% of potato residues, 20-30% of benne straw, 10-30% of gravel, 10-15% of perlite and 5-15% of peat. The soilless cultivation medium and the preparation method of the soilless cultivation medium have the advantages that recycling of waste such as the potato residues and the benne straw is achieved, the soilless cultivation medium has the good chemical inhibition function and the good biological protection function after being processed through fermentation and disinfection, the number of diseases, insect pests and weeds can be reduced, storage and transport are convenient, when transplanting is carried out, roots cannot be damaged, seedlings cannot be broken, and the survival rate of transplanting is ensured; microcellular foaming is carried out by using adhesives, foaming agents and vulcanizing agents, a specific hole-connected elastomer is formed, root systems can be protected in the process of transport and transplanting, and the survival rate is increased.

The invention provides an amide polymer shale inhibitor for drilling fluid. The amide polymer shale inhibitor is characterized by being prepared from, by mass, 10%-20% of acrylamide, 5%-10% of 300# liquid wax, 10%-20% of hexadecyl dimethyl benzyl ammonium chloride, 2%-8% of dimethyl diallyl ammonium chloride, 20%-30% of methacryloyloxyethyl trimethyl ammonium chloride, 15%-25% of acrylic acid, 2%-5% of emulsifiers, 0.03%-0.6% of an initiator and 20%-40% of water, wherein the emulsifiers are any two of Span60, Tween80, Span80, Tween60 and hexadecyl trimethyl ammonium bromide, and the initiator is any one of ammonium persulfate-ethanol, ammonium persulfate-pentaerythritol, ammonium persulfate-sodium hydrogen sulfite and ammonium persulfate-sodium sulfite. By means of a synergistic effect of chemical inhibiting and enveloping and blocking of hydrophobic groups, the good inhibition effects can be achieved, integral inhibition is achieved, and the problem that an original shale inhibitor is bad in inhibition effect under the complex condition is solved.

The invention relates to a method for culturing cotton resisting a micro-bundle disease. The method comprises the following steps: using sea island cotton or land-sea hybrid cotton with high resistance and immunity to the greensickness and the blight of a main cotton micro-bundle disease as a parental stock; using a general upland cotton specie or strain as scion; grafting at a seedling stage; andculturing grafted seeds in an environment with the temperature of 25-35 DEG C, the relative humidity of 85-95 DEG C and indirect lighting for 5-10 days. The method selects the sea island cotton or the land-sea hybrid cotton as the parental stock and inhibits or prevents micro-bundle pathogens from expanding under the effect of physical obstacle (texture structure) or chemical inhibition thereof or interaction the physical obstacle (texture structure) or the chemical inhibition thereof so as to present immunity or high resistance to the greensickness and the blight of a main cotton micro-bundle disease. The method has high grafting survival rate (higher than 90 percent), grafting cotton has strong advantages, high yield, longer stem than non-graft scion, larger fruit branch number than thenon-graft scion and strong-growth characteristic similar to the parental stock.

The invention discloses a clean and safety lignocellulose raw material pretreatment method. The method includes: grinding natural lignocelluloses as a raw material, adopting 10%-20% acetic acid (mass concentration) for pretreatment for 10-60min at 120-150 DEG C, recovering acetic acid by vacuum evaporation to obtain a pretreated material, and adding cellulase to obtain glucose by enzyme hydrolysis. By adoption of the clean and safety lignocellulose raw material pretreatment method, more than 75% of hemicelluloses and a small part of lignin in the natural lignocellulose raw material can be degraded, a chemical inhibition effect of hemicelluloses and lignin on cellulase catalytic hydrolysis is remarkably broken, and cellulase catalytic hydrolysis yield is increased to 85% above. Compared with an existing pretreatment method, the clean and safety lignocellulose raw material pretreatment method has advantages that reaction temperature can be remarkably lowered while heat consumption and resisting substance forming amount are reduced; more importantly, acetic acid is safer and milder than inorganic acid and lower in requirement on corrosion resistance of production equipment, and complete acetic acid recovery can be realized by conventional vacuum evaporation, so that high cleanness, safety and economy are achieved.

The invention discloses a mud shale stabilizer. The mud shale stabilizer is acquired through the reaction of a silane coupling agent modified nanosilicon dioxide and a dendritic polymer. The inventionfurther provides a preparation method of the mud shale stabilizer. The mud shale stabilizer is prepared through the method. The hardness and softness combined physical blocking is realized with the help of the rigid blocking of the nanosilicon dioxide and the deformation filling of the nanoscale dendritic polymer, moreover, the strong absorption between a large quantity of end groups and the surface of the mud shale inhibits the hydration and swelling of the mud shale to achieve efficient chemical inhibition. The mud shale stabilizer achieves the double functions of the nanoscale physical blocking and the chemical inhibition, a new way and method is provided for the stabilizing the mud shale, and the mud shale stabilizer is of great theoretical significance and has an important application value.

The invention publishes a kind of biology method to prepare methanol using methane catalysis. The method adopts the technology as follows. Fist, bacterial cells are oxidized by methane and the outcome is as catalyst. Second, add mixed gas of methane, carbon dioxide and oxygen to membrane reactor and start up reaction under the condition of 32-40deg.C and 0-1.2MPa. after the reaction the aqueous solution containing methanol can be gotten. The invention solves the problems that cytoactive will depress because of the consumption of NADH lead by chemical inhibitor. In this method, the reaction can continue to make sure that coenzymes NADH can rebirth in situ in the reaction system.

Compositions and methods of preparation and use for controlled release scale inhibitors used in hydraulic fracturing operations in oil and gas wells. The controlled release scale inhibitors comprise modified polyphosphate glasses having predetermined dissolution rates for controlled release of chemical inhibitors in induced hydraulic fractures in hydraulic fracturing treatment of oil and/or gas wells.

Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method including measuring the enzymatic activity of neuraminidase (NA) in the sample under one or more differentiating conditions selected from the group consisting of pH, binding to anti-NanA antibody, size exclusion, hemagglutinin (HA) binding, chemical inhibition, and combinations thereof.

The invention relates to a detection reagent for detecting lactic dehydrogenase isozyme 1 through a chemical inhibition method. The detection reagent comprises a reagent R1 and a reagent R2. The detection reagent is characterized in that the reagent R1 comprises a biological buffer solution in which a solute in the reagent R1 ranges from 50 mmol/L to 150 mmol/L in concentration, 1.0 mmol/L to 1.5 mmol/L of L-lithium lactate, 1.5 mmol/L to 2.5 mmol/L of sodium perchlorate, 1ml/L to 5ml/L of hydroxy ethidene diphosphonic acid, 0.1 g/L to 1g/L of octadecyl trimethyl ammonium bromide, 0.1 ml/L to 1 ml/L of polyoxyethylene alkyl ether, and 0.5 ml/L to 5 ml/L of preservative. The reagent R2 comprises a buffer solution in which a solute in the reagent R2 ranges from 50 mmol/L to 150 mmol/L in concentration, 8-12 mmol/L NAD+ and 0.5-5 ml/L of preservative. The lactic dehydrogenase isozyme 1 detection reagent has the advantages of being high in accuracy and cheap in price.

Methods for increasing the levels of lipids in oleaginous algae are described. Lipid levels in algae can be increased by stress, such as nutrient stress, after which the lipid can be harvested from the algae using a non-destructive extraction process. The stress may be provided in a periodic or “pulsed” fashion. Lipid levels in oleaginous algae can also be increased using simulated stress by treating the algae with a chemical inhibitor or by using recombinant technology to insert a sequence expressing a protein such as a nitrate reductase inhibitor that is expressed when a stressed state is desired. A method for maintaining the temperature and water levels of algae ponds using buoyant spheres is also described.

Compounds that bind to Bfl-1 as well as conjugates of such compounds are provided. Various embodiments additionally provide methods of using such compounds to identify additional anti-apoptotic Bfl-1 binding compounds. Methods of using such compounds to increase apoptosis in a cell are also provided.

Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.

The invention discloses an intelligent nanometer blocking agent for water-based drilling fluid and a preparation method thereof. The intelligent nanometer blocking agent is prepared from, by weight, 20-82 parts of intelligent polymer-modified magnetic nanoparticles, 3-45 parts of polyethylene glycol and 0.5-24 parts of polytetramethylene glycol. The preparation method includes the steps that the intelligent polymer-modified magnetic nanoparticles are added into water, polyethylene glycol is added with constant stirring, the mixture is subjected to a reaction for 3-5 hours, polytetramethylene glycol is added, the mixture is subjected to a reaction for 4-7 hours, water is evaporated, the product is dried for 4 hours at 60-75 DEG C, and then the intelligent nanometer blocking agent for the water-based drilling fluid is obtained. The preparation method has the advantages that the hydrophilia and hydrophobicity of the intelligent nanometer blocking agent can change correspondingly along with different formation temperatures and drilling fluid pH values, so that in the shale formation drilling process, while micro pores in the well wall are physically blocked, a water molecule repelling effect is achieved, water is chemically restrained from approaching the well wall, and then the water blocking performance of the drilling fluid is significantly improved.

Methods for overcoming multiple herbicide resistance (MHR) in plants using inhibitors of GST suppression of Formula (I), novel chemical inhibitors of Formula (Ia), compositions comprising compounds of Formula (I), and uses and methods relating thereto.