Shuangzuotai vagina effervescence tablet and preparation method thereof

Abstract

The invention discloses a Shuangzuotai vagina effervescence tablet which is prepared from the following raw materials: 200 g of metronidazole, 160 g of mycosporin, 8 g of chlorhexidine acetate, 50-53 g of starch, 125 g of citric acid, 109.6 g of sodium bicarbonate, 102-106 g of lactose, 8-12 g of sodium dodecyl sulfate, 8 g of magnesium stearate, 25 g of 10 wt% starch slurry and 25 g of 4 wt% HPMC solution. According to the Shuangzuotai vagina effervescence tablet, as citric acid and sodium bicarbonate are used as an effervescing agent, a proper amount of sodium dodecyl sulfate is added to be used as a foaming agent, and starch which has good disintegration performance and is economical and easily available and a proper amount of lactose are used as a filler, the prepared tablet can reach the established clinical medication standard and general principles of the Chinese Pharmacopeia 2010 second section on tablets in various aspects such as appearance, foam volume, pH value and the like.

Description

technical field [0001] The invention relates to a Shuangzotai vaginal effervescent tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Bacterial vaginosis is a mixed bacterial infection and the most common lower genital tract infection in women of childbearing age. A variety of bacteria are parasitic in the vagina of healthy women, forming a normal vaginal flora, among which Lactobacillus is dominant, with a detection rate of 69%. Reproduction mainly includes mixed infections caused by Gardnerella, Bacteroides, Proteus and Mycoplasma. [0003] Shuangzotai vaginal effervescent tablet is developed for bacterial vaginosis. It was first developed and marketed by Shaanxi Jinfang Pharmaceutical Co., Ltd., with the approval number: (94) Weiyao Zhunzi No. X-117, 2002 It has been converted into a national drug standard issued by the bureau. The drug is a compound preparation, and its main component...

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Problems solved by technology

[0005] There are many kinds of Shuangzotai vaginal effervescent tablets in the prior art, but there is still room for improvement in aspects such as foaming volume and pH value

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