The invention belongs to the technical field of aquaculture, and particularly discloses a farming method of selenium-enriched fish. According to the farming method of the selenium-enriched fish, the fish is fed with selenium-enriched feed in percentage by the body weight of the fish in a staging manner, and fish pond management is managed, wherein the selenium-enriched feed is prepared according to the following main steps: mixing selenium-enriched rice bran, selenium-enriched corn, silkworm chrysalis, sesame, selenium-enriched rapeseed oil, an additive and inorganic salt in certain parts by weight, crushing, sieving, puffing, granulating, drying, spraying with oil, and cooling; the additive is prepared from codonopsis pilosula, areca nut, turmeric, rosa laevigata, white houttuynia cordata, astragalus membranaceus, wild jujube seed, agastache rugosa, oligosaccharide, galactooligosaccharide, mannan oligosaccharide and the like in certain parts by weight. According to the farming method of the selenium-enriched fish, the fish is reasonably fed with the selenium-enriched feed with rich and comprehensive nutrition, high selenium content and a good selenium-supplementing effect, so that the selenium content of fish meat is effectively increased, and people can achieve the purpose of supplementing selenium to human bodies through consumption of the fish meat, and the problem of selenium shortage in the human bodies is effectively solved.