The invention discloses a toothpaste formula which comprises the following components according to parts by mass: 10-18 parts of orange peel, 1-10 parts of quassia, 1-9 parts of Chinese lobelia, 10-20 parts of herba violae, 1-10 parts of pueraria flower, 5-15 parts of root of common peony, 10-25 parts of lonicerae flos, 10-50 parts of stevia rebaudiana, 2-6 parts of salt, 10-15 parts of mint, 3-8 parts of reed rhizome, 2-10 parts of lysimachia christinae hance, 10-30 parts of folium isatidis, 2-10 parts of chrysanthemum, 15-30 parts of lotus leaves, 10-20 parts of sorbitol, 1-10 parts of green tea, 3-15 parts of arabian jasmine flower, 2-6 parts of folium mori, 4-15 parts of honeysuckle, 2-20 parts of tendril-leaved fritillary bulb, 2-8 parts of herba andrographitis, 5-15 parts of endothelium corneum gigeriae galli, 2-15 parts of eupatorium, 5-10 parts of rhizoma acori graminei, 1-10 parts of radix asparagi, 5-10 parts of sun plant, 2-10 parts of lantern plant calyx, 3-15 parts of fruit of immature citron, 5-10 parts of folium eriobotryae, and 10-15 parts of aromatic. The toothpaste formula has the effects of preventing bleeding gums and swelling gums, particularly has a remarkable effect on periodontitis, and has an effect of alleviating a slight oral disease at the same time.