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Process for preparing inflammation-resolving gall-bladder-excreting tablets

A technology of Xiaoyanlidan tablets and process steps, applied in the field of preparation technology of Xiaoyanlidan tablets, can solve the problems of high production time, large solvent loss and high production cost, and achieves reduced production cost, shortened concentration time, practical application strong effect

Inactive Publication Date: 2014-12-10
JIANGXI JIUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the Pharmacopoeia has a conventional process for extracting the concentrated solution of the raw materials of Xiaoyan Lidan Tablets, the traditional concentration method has the disadvantages of high energy consumption, low yield, long production time, large solvent loss, unstable drug quality, and high production cost. question

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0025] 1, a kind of Xiaoyan Lidan Tablet, is made up of the medicine of following weight ratio: Andrographis paniculata 868g, Xi Huangcao 868g, bitter wood 868g, it is characterized in that, adopts following technological steps to make:

[0026] 1), with Andrographis paniculata, extract twice with 85% ethanol, first add alcohol 10 times the amount of extraction for 2 hours, add alcohol for the second time 8 times the amount of extraction for 2 hours;

[0027] 2) Combine the filtrates and concentrate under reduced pressure at -0.08Mpa at 75°C to 85°C; concentrate until the relative density of the extract at 60°C is 1.30 to 1.40;

[0028] 3) Add water to decoct Xihuangcao twice, decoct with 10 times the amount of water for 3 hours for the first time, and decoct for 2 hours with 10 times the amount of water for the second time;

[0029] 4) Concentrate the combined filtrate under reduced pressure at -0.08Mpa at 75°C to 85°C; concentrate until the relative density of the extract at...

Embodiment 2

[0033] The invention relates to a Xiaoyan Lidan tablet. The disintegrating agent of the auxiliary material during granulation is cross-linked polyvinylpyrrolidone, the binder is 60% ethanol solution, the filler is starch, and the lubricant is magnesium stearate.

Embodiment 3

[0035] A kind of Xiaoyan Lidan tablet, the disintegrating agent of auxiliary material when granulating is the mixture of carboxymethyl starch sodium and cross-linked carboxymethyl cellulose sodium, the binding agent is 40% ethanol solution; the filler is lactose and micro A mixture of crystalline cellulose; the lubricant is talc.

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Abstract

The invention discloses a process for preparing inflammation-resolving gall-bladder-excreting tablets. In order to well control the quality of the inflammation-resolving gall-bladder-excreting tablets, when the active ingredients of each traditional Chinese medicine material are extracted, the amount of solvents during extraction, the extracting, concentrating and drying conditions and other processes are researched. On one hand, the optimal extraction and concentration process of each traditional Chinese medicine material in the inflammation-resolving gall-bladder-excreting tablets is determined, and the extraction rate of the active ingredients of common andrographis herb, linearstripe rabdosia herb and quassia is improved; on the other hand, the practicality of the process is high, the concentration time is shortened, the production cost can be obviously reduced, and the process is suitable for expanded production.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation process of Xiaoyan Lidan Tablets. Background technique [0002] Xiaoyan Lidan Tablets, a traditional Chinese medicine preparation, is a Chinese patent medicine commonly used clinically to treat acute cholecystitis and cholangitis. Its formula includes 868g of Andrographis paniculata, 868g of Xihuangcao, and 868g of bitter wood. [0003] Andrographis paniculata, also known as spring lotus and autumn willow, is happy at first sight. Lamicarpa, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass, etc. have the functions of clearing away heat, detoxifying, reducing inflammation, reducing swelling and relieving pain. Andrographis paniculata has anti-inflammatory and detoxifying effects, and has been clinically used in various infectious diseases, including trauma infection, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and c...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/16A61P1/16
Inventor 任国权许继石许明景
Owner JIANGXI JIUHUA PHARMA
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