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Dispersion tablet for protecting liver and promoting bile and its preparing method

A technology for protecting liver and gallbladder, dispersible tablets, applied in the field of medicine, can solve the problem of no patent application for liver protecting and gallbladder dispersible tablets, and achieves the advantages of alleviating tissue ischemia-reperfusion injury, high bioavailability and rapid drug dissolution. Effect

Inactive Publication Date: 2007-04-11
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These inventions have been improved in the preparation process and dosage form, but in the search, there is no report on the study of Baogan Lidan Dispersible Tablets in China, and there is no patent application for Baogan Lidan Dispersible Tablets at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Based on 1000 tablets of Baogan Lidan Dispersible Tablets, weigh 80g of Xihuangcao extract dry paste, 80g of Andrographis paniculata extract dry paste, 80g of Bitterwood extract dry paste and Scutellaria baicalensis extract after crushing and screening through a 150 mesh sieve. 38g of product crystallization, 12g of anhydrous sodium sulfite, simultaneously take by weighing 32g of microcrystalline cellulose and 16g of lactose through drying, pulverizing and screening through 120 mesh sieves in proportion;

[0065] Put the above-mentioned raw and auxiliary materials in a mixer and mix them evenly, and press them into Φ15mm flakes with a tablet weight of 370-380 mg, and then granulate them with a 20-mesh sieve in a granulator;

[0066] The prepared granules are then placed in a granulator and sized with a 16-mesh sieve to remove oversized particles, and then the low-substituted hydroxypropyl cellulose that has been dried, pulverized and screened through a 120-mesh sieve is ...

Embodiment 2

[0083] Liver-protecting and gallbladder-protecting dispersible tablets are made of the following components by weight ratio (unit: kilogram):

[0084] Xi Huang Grass Extract Dry Cream 85

[0085] Andrographis paniculata extract dry paste 85

[0086] Bitterwood Extract Dry Balm 85

[0087] Scutellaria baicalensis extract crystallized 40

[0088] Anhydrous sodium sulfite 13

[0089] Microcrystalline cellulose 32.5

[0090] Low-substituted hydroxypropyl cellulose 34

[0091] Lactose 18

[0092] Magnesium stearate 3.5.

[0093] The preparation method of the above-mentioned liver-protecting and gallbladder dispersible tablet is completed by the following steps:

[0094] (1) Weighing and pulverizing by weight proportion and through 150 mesh sieve extract dry paste of Xihuangcao, dry extract of Andrographis paniculata extract, dry paste of bitterwood extract, crystallization of Scutellaria baicalensis extract, anhydrous sodium sulfite, at the same time Weigh microcrystalline ...

Embodiment 3

[0098] Liver-protecting and gallbladder-protecting dispersible tablets are made of the following components by weight ratio (unit: kilogram):

[0099] Xihuang grass extract dry paste 77

[0100] Andrographis paniculata extract dry paste 77

[0101] Bitterwood Extract Dry Balm 77

[0102] Scutellaria baicalensis extract crystallized 25

[0103] Anhydrous sodium sulfite 10

[0104] Microcrystalline Cellulose 30

[0105] Low-substituted hydroxypropyl cellulose 30

[0106] Lactose 13

[0107] Magnesium stearate 3.

[0108] The preparation method of the above-mentioned liver-protecting and gallbladder dispersible tablet is completed by the following steps:

[0109] (1) Weighing and pulverizing by weight proportion and through 150 mesh sieve extract dry paste of Xihuangcao, dry extract of Andrographis paniculata extract, dry paste of bitterwood extract, crystallization of Scutellaria baicalensis extract, anhydrous sodium sulfite, at the same time Weigh microcrystalline cellu...

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PUM

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Abstract

The invention discloses a dispersible tablet protecting liver and gall blader and prepared by components with proportioning by weight as follows: extracting dry paste of serrate rbdosia herb 77-85,extracting dry paste of creat 77-85, extracting dry paste of quassia 77-85, crystals of the root of large-flowered skullcap extraction 35- 40, anhydrous sodium sulfite 10-13,microcrystalline cellulose 30-32.5,low-substituted hydroxyproxyl cellulos 30-34,milk sugar 13-18,magnesium stearate 3-3.5. Preparation thereof, taking ground main components separately according to percent by weight, putting thereof into mixing machine to be stirred evenly, being pressed into thin tablet of phi15mm with weight of 350-400mg, then making into pellet, sorting out thereof, again adding dried and ground low-substituted hydroxyproxyl cellulos and magnesium stearate, mixing thereof evenly, finally pressing into tablets, packing with AL plastic to obtain said dispersible tablets.

Description

technical field [0001] The invention relates to a dispersible tablet and a preparation method thereof, in particular to a liver-protecting gallbladder dispersible tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Although the Xiaoyan Lidan Tablet preparation recorded in the 1995 edition of the Chinese Pharmacopoeia in clinical use in 1997 was added to this institute, although it has been widely used and has definite curative effects, the tablet has a large amount of adjuvant materials and low bioavailability. The long disintegration time limit and other deficiencies are not suitable for the development trend of modern treatment and application of traditional Chinese medicine. [0003] The application number is: 99113258.0 "Preparation Process of Xiaoyan Lidan Granules" discloses a preparation process of Xiaoyan Lidan Granules; the invention of Application No. 200410041023.3 discloses the preparation of a Xiao...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61P1/16
Inventor 常宏文张尚立马剑锋张海龙
Owner SHANDONG UNIV
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