60results about How to "Fast bioavailability" patented technology

The invention relates to an Entecavir soft capsule for treating hepatitis B and process for its preparation, by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing soft capsule through the conventional techniques in the pharmaceutical industry.

A dispersing tablet of Dragon's blood for treating the acute cardiovascular and cerebrovascular diseases is disclosed.

The soft Chinese medicine capsule for treating chronic cholecystitis and gall-stone consists of soft capsule coating and contained matter. The contained matter includes dementholized mint oil and medicinal supplementary material capable of being mixed homogeneously with dementholized mint oil, and the supplementary material is selected from polyglycol-400, Tween-80, glycerine, vegetable oil, etc. The preparation has effectively controlled volatilization of dementholized mint oil, stable quality, homogeneously distributed medicine component, fast leaching, high bioavailability, and well masking of the special smell of dementholized mint oil for easy taking.

The present invention relates to a new type medicine preparation memantine hydrochloride dispersing tablet and its preparation method. Its composition includes (by wt%) 0.5-95% of memantine hydrochloride, 20-90% of filling agent, 5-30% of disintegrant agent, 1-30% of corrective agent, 0.1-5% of lubricating agent and 0.5-5% of metarchon agent.

The invention relates to a medicine composite for curing combined external head injuries in clinical nursing. The medicine composite is prepared from following raw materials in parts by weight: 27 parts of prepared rehmannia root, 25 parts of Chinese angelica, 25 parts of radix paeoniae rubrathe, 22 parts of curcuma rhizome, 22 parts of dandelion, 20 parts of radish seed, 20 parts of patrinia herb, 18 parts of plantain seed, 18 parts of Japanese eupatorium, 17 parts of eucommia, 15 parts of campsis grandiflora, 15 parts of cassia twig, 15 parts of perilla leaf, 15 parts of Chinese yam, 13 parts of banksia rose, 12 parts of mulberry, 12 parts of poria cocos, 12 parts of licorice, 10 parts of saposhnicovia divaricata, 10 parts of trichosanthes root, 10 parts of cyperus rotundus, 10 parts of albizia bark, 8 parts of ligusticum wallichii, 8 parts of edible fungus, 7 parts of barbat skullcap, 5 parts of almond, 5 parts of phellodendron, 3 parts of prunella vulgaris and 3 parts of wolfberry. The materials mentioned above are used together to bring out the best in each other, the medicine composite has a rapid curative effect on the combined external head injuries and the application prospect is vast.

The invention discloses an oral milk coagulant for treating infant thrush. The oral milk coagulant is prepared from the following components by weight: 150 million units of 10-20 million/ml nystatin, 8ml of medical 5% sodium bicarbonate, 0.5g of vitamin C, 250mg of vitamin B, 2ml of cod-liver oil, 10ml of liquid pectin, 1g of lactose and 0-0.2ml of traditional Chinese medicine extract. Compared with the prior art, the oral milk coagulant has the effects of simpleness in use, easiness for coating, lasting pasting effect of medicines at an infected part, long action time, rapid effect and high bioavailability; by adopting the oral milk coagulant, the problems of unprofessional operation of family numbers of patients in drug separation, waste of traditional Chinese medicines during a drug blending process and difficulty in drug application; clinical trials prove that the oral milk coagulant disclosed by the invention has a significant effect in treating infant thrush and has no toxic and side effects through the selection of proper components in proper proportion.

The invention relates to an ilaprazole enteric orally disintegrating tablet and a preparation method thereof. The ilaprazole enteric orally disintegrating tablet comprises the components in percentage by weight as follows: 1-5% of ilaprazole, 8-10% of hollow pill core, 2-5% of stabilizer, 10-15% of isolating layer, 15-20% of enteric coating, 35-70% of filler and 10-20% of disintegrating agent. The invention provides the ilaprazole enteric orally disintegrating tablet which is small in grain size, quick to absorb, high in bioavailability, good in taste, easy to swallow, good in disintegrating effect, strong in compressibility and convenient for patients to take, and the preparation method thereof.

The invention belongs to the technical field of medicine and discloses a Chinese medicinal preparation for treating recurrent oral ulceration. The Chinese medicinal preparation for treating recurrent oral ulceration is prepared from the following raw materials: 20 parts of natural indigo, 18 parts of sessile stemona root, 15 parts of humifuse euphorbia herb, 15 parts of curcuma zedoaria, 12 parts of snake gourd fruit, 12 parts of barbed skullcap herb, 12 parts of amur cork tree bark, 10 parts of platycodon grandiflorus, 10 parts of gardenia, 10 parts of liquorice, 10 parts of astragalus, 10 parts of ophiopogon japonicus, 7 parts of dark plum fruit, 7 parts of prunella vulgaris, 5 parts of cortex albiziae, 5 parts of muskmelon seed, 5 parts of uncaria tomentosa and 3 parts of mulberry leaf. The Chinese medicinal preparation disclosed by the invention has a short treatment course for treating recurrent oral ulceration and has a high total effective rate; after the Chinese medicinal preparation is applied and recurrent oral ulceration is healed, recurrent oral ulceration is difficult to recur moreover, the process is simple, the production cost is reduced and the economical burden of a patient is reduced.

The invention belongs to the field of medicaments, and particularly relates to an emulsion of N-(2-(2-amine) oxyethio-based benzothiazole-6-)-2-formamide derivatives and a preparation method thereof. The invention aims at providing a suitable dosage form for increasing the N-(2-(2-amine) oxyethio-based benzothiazole-6-)-2-formamide derivatives, especially for solubility and bioavailability of CBTA (carboxyl benzene triazole), and finally the inventor prepares the N-(2-(2-amine) oxyethio-based benzothiazole-6-)-2-formamide derivatives into the emulsion which is provided for clinic application.According to the prepared emulsion, the particle size of the disperse phase is 0.05mum-1mum, the average particle size is 150nm-400nm, so that the prepared emulsion belongs to submicroemulsion; the dispersion degree of liquid drops in the emulsion is large, the absorption of medicines and the acting of medicine effect are fast and the bioavailability is high.

The present invention provides a Chinese medicine perlingual preparation for relieving cough and reducing sputum and its preparation method. It is made up by using scrophularia root as main raw material and using tangerine peel as auxiliary raw material through a certain preparation process. Said invention can be made into the dosage forms of lozenge, sugar-coated lozenge and perlingual pills.

The invention discloses a preparation with the new efficacies of activating blood circulation and removing blood stasis and a preparation method thereof. The preparation comprises the following components in parts by weight: 250-350 parts of motherwort, 150-250 parts of angelica sinensis, 100-200 parts of ligusticum wallichii, 80-120 parts of sodium alginate, 25-35 parts of hydroxy propyl methyl cellulose, 145-270 parts of glucan, 30-70 parts of calcium hydrophosphate, 50-70 parts of sodium carboxymethyl starch, 10-30 parts of lauryl sodium sulfate and 3-5 parts of micro-powder silica gel. The preparation is prepared into a dispersing tablet, and the preparation method comprises the following steps: extracting and preparing a medicinal material into dry paste powder, preparing the dry paste powder into an inclusion compound and then further preparing the inclusion compound into the dispersing tablet. In the preparation disclosed by the invention, the solubility of an insoluble drug in the dry paste powder extracted from the medicinal material can be significantly improved, the disintegration time is shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost, low in energy consumption and easy to realize industrial production.

The invention belongs to the technical field of medicines and discloses a nymphaea tetragona chewable tablet which adopts fine powder of nymphaea tetragona petals as active ingredients, is assisted by other pharmaceutic adjuvants and comprises a filling agent, a flavoring agent, a lubricating agent. The chewable tablet has the advantages of good taste, convenient administration, fast absorption, fast effect and high bioavailability, and has better application prospect.

The invention discloses a plant-derived compound organic growth regulating tablet, belonging to the field of fertilizers. The plant-derived compound organic growth regulating table comprises, by weight, 10 to 15 parts of Radix Aucklandiae, 10 to 15 parts of coix seeds, 10 to 15 parts of chicken's gizzard-membranes, 5 to 10 parts of coptis, 15 to 20 parts of licorice roots, 30 to 35 parts of hydroxypropyl methyl cellulose, 20 to 30 parts of acrylic resin, etc. The compound organic growth regulating tablet provided by the n has a wide application range and can effectively improve the survival rate of crops in a seedling stage; a slow-release agent is fast in action, long in action time and easy to absorb; since the medicines are micronized, the solubility of the medicines is obviously improved, so the bioavailability of the medicines is improved, the usage amounts of the medicines are reduced, the resources of Chinese herbal medicines are saved, and the toxic and side effects of the chemical agent are lowered; the raw materials mentioned above are easily available; the preparation cost for the tablet is low; and resistance development can be delayed, so the service life of the chemical agent is prolonged. The organic growth regulating tablet provided by the invention is balanced and comprehensive in nutrition.

The invention discloses a drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and a preparation method thereof. The drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria comprises the following components by weight: 100 parts of erythromycin estolate, 50-70 parts of sodium alginate, 40-50 parts of hydroxypropyl methyl cellulose, 150-190 parts of glucan, 30-50 parts of sodium carboxymethyl starch, 30-40 parts of sodium dodecyl sulfate, and 5-7 parts of aerosol. The preparation method provided by the invention employs sodium alginate inclusion technology to prepare erythromycin estolate into an inclusion compound, and then the main drug inclusion compound is further prepared into dispersible tablets. The erythromycin estolate product prepared by the method provided by the invention has increased solubility, high dissolution rate, shortened disintegration time, and improved bioavailability and curative effect. The preparation method has the characteristics of simple process, low production cost, low energy consumption, and easy realization of industrial production.

The invention belongs to the technical field of medicine preparations, and in particular relates to an ornidazole orally disintegrating tablet preparation and a preparation method of the ornidazole orally disintegrating tablet preparation. The ornidazole orally disintegrating tablet is prepared from the following ingredients in percentage by weight: 50-80 % of ornidazole, and 20-50 % of an excipient, wherein the excipient comprises one or more of a disintegrating agent, an adhesive, a corrigent, a lubricant and a glidant. The ornidazole orally disintegrating tablet provided by the invention has the advantages that the disintegrating is rapid, the mouthfeel is excellent, no gritty sense exists, no discomfort exists, the stability is stable, the curative effects are reliable, the effect is timely, the absorption is rapid, the bioavailability is greatly increased, the demands of patients are conformed, in addition, the preparation process is simple, and is suitable for large-scale production, etc.