60results about How to "Fast bioavailability" patented technology

The invention relates to an Entecavir dispersible tablet for treating hepatitis B and process for its preparation by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing tablet through the conventional techniques in the pharmaceutical industry.

The invention relates to a pharmaceutical composition having a blood sugar reducing effect. The pharmaceutical composition is prepared from the following raw materials: astragalus membranaceus, gorgon fruit, fructus rosae laevigatae, seed of Chinese dodder, burdock root, rhizoma anemarrhenae, yam, lalang grass rhizome, angelica, chrysanthemum, purslane, root of red-rooted salvia, radix ophiopogonis, ginseng, rhizoma atractylodis, folium mori, dendrobe, polished round-grained rice, medlar, root of Chinese trichosanthes, root of common peony, baked ginger, dogwood, raspberry, radix polygonati officinalis, myrrh, root of kudzu vine, ligusticum wallichii, prepared rehmannia root and fruit of Chinese magnoliavine. The pharmaceutical composition has high effective rate on diabetes and avoids relapse after curing; the pharmaceutical composition is simple in process, can low production cost and relieve economic burden of patients, and has a broad application prospect.

The invention relates to an Entecavir soft capsule for treating hepatitis B and process for its preparation, by using Entecavir as raw material, charging auxiliary materials of specific species and proportions, and preparing soft capsule through the conventional techniques in the pharmaceutical industry.

The invention relates to a traditional Chinese medicine preparation-Liuwei Anxiao Pills and a preparing method of the traditional Chinese medicine preparation, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is characterized by comprising the following components in weight percent: 40-55 parts of Tibet inula, 160-200 parts of rhubarb, 80-100 parts of Kaempferia galangal, 200-250 parts of Gypsum Gypsum Rubrum, 110-150 parts of myrobalan and 250-300 parts of Tronae. In the preparing method, on the basis of the traditional process, the original single crushing pattern is changed, a sterilization process is changed, i.e. the original moist heat sterilization process for medicine powder produced after medicinal slices are crushed is changed into a cobalt 60 irradiation process, and the pattern of collecting and coating volatile oil is changed. The preparing method sufficiently ensures that volatile components in the Tibet inula are not lost and oily components in the Tibet inula are not lost. In addition, the drug effect is more effectively ensured, the product name quality is ensured, and benefits of patients are guaranteed.

The invention relates to gabapentin mecobalamin dispersion tablets for treating peripheral nervous diseases such as psychalgia syndrome, etc. and a preparation method thereof, and aims to make up the disadvantages in the prior art and provide a novel preparation, i.e. the gabapentin mecobalamin dispersion tablets to patients and medical workers; wherein, the gabapentin mecobalamin dispersion tablets have swift disintegration, fast absorption and easy administration, can increase the bioavailability and the blood concentration of drugs, and increase the abirritation. Gabapentin mecobalamin is used as a raw material, auxiliary materials with specific types and proportions are added in, and the mixture is pressed into tablets according to the conventional technique of the preparation course.

High penetration compositions (HPC) of a parent compound, which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capable of being converted to parent drugs or parent drug-related compounds such as metabolites after crossing one or more biological barriers and thus can render treatments for the conditions that the parent drugs or parent drug-related compounds can. Additionally, the HPCs are capable of reaching areas that their parent drugs or parent drug-related compounds may not be able to access or to render a sufficient concentration at the target areas HPCs of NSAIA, for example, have demonstrated indications such as treating hair loss. A HPC can be administered to a subject through various administration routes, e. g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

The invention relates to the fields of traditional Chinese medicine preparation processing and functional food processing, in particular to a preparation method and use of a compound recipe spina dateseed composite extract. The compound recipe spina date seed composite extract is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight of 8-12 partsof spina date seeds, 6-10 parts of lily bulbs, 6-10 parts of poria cocos, 6-10 parts of mulberries, 5-9 parts of Chinese wolfberry fruits, 6-10 parts of dried longan pulp, 6-10 parts of rhizoma polygonati and cyclodextrin in the same parts by weight as the traditional Chinese medicine materials. The compound recipe spina date seed composite extract is prepared into tablets, capsules, granules, pills and oral liquid to be used for preparing functional foods or wine products according to a conventional technology.

The invention relates to a drug preparation for infantile diarrhea. The drug preparation is prepared from the following raw materials: white hyacinth bean, Chinese yam, red peony root, zedoray rhizome, dandelions, radish seed, largehead atractylodes rhizome, pomegranate rinds, agarics, almonds, Indian bread, semen coicis, liquorice, divaricate saposhnikovia root, nutgrass galingale rhizome, common andrographis herb, dried gingers, purslane herb, orange fruit, dried tangerine peel, garden burnet root, Sichuan lovage rhizome, amur corktree bark, barbary wolfberry fruit and hawthorns. The drugs are used jointly and bring out the best in each other, so that the drug preparation takes an effect on infantile diarrhea quickly and has extensive application prospects.

The soft Chinese medicine capsule for treating chronic cholecystitis and gall-stone consists of soft capsule coating and contained matter. The contained matter includes dementholized mint oil and medicinal supplementary material capable of being mixed homogeneously with dementholized mint oil, and the supplementary material is selected from polyglycol-400, Tween-80, glycerine, vegetable oil, etc. The preparation has effectively controlled volatilization of dementholized mint oil, stable quality, homogeneously distributed medicine component, fast leaching, high bioavailability, and well masking of the special smell of dementholized mint oil for easy taking.

The present invention relates to a new type medicine preparation memantine hydrochloride dispersing tablet and its preparation method. Its composition includes (by wt%) 0.5-95% of memantine hydrochloride, 20-90% of filling agent, 5-30% of disintegrant agent, 1-30% of corrective agent, 0.1-5% of lubricating agent and 0.5-5% of metarchon agent.

The invention relates to a medicine composite for curing combined external head injuries in clinical nursing. The medicine composite is prepared from following raw materials in parts by weight: 27 parts of prepared rehmannia root, 25 parts of Chinese angelica, 25 parts of radix paeoniae rubrathe, 22 parts of curcuma rhizome, 22 parts of dandelion, 20 parts of radish seed, 20 parts of patrinia herb, 18 parts of plantain seed, 18 parts of Japanese eupatorium, 17 parts of eucommia, 15 parts of campsis grandiflora, 15 parts of cassia twig, 15 parts of perilla leaf, 15 parts of Chinese yam, 13 parts of banksia rose, 12 parts of mulberry, 12 parts of poria cocos, 12 parts of licorice, 10 parts of saposhnicovia divaricata, 10 parts of trichosanthes root, 10 parts of cyperus rotundus, 10 parts of albizia bark, 8 parts of ligusticum wallichii, 8 parts of edible fungus, 7 parts of barbat skullcap, 5 parts of almond, 5 parts of phellodendron, 3 parts of prunella vulgaris and 3 parts of wolfberry. The materials mentioned above are used together to bring out the best in each other, the medicine composite has a rapid curative effect on the combined external head injuries and the application prospect is vast.

The invention relates to compound domperidone dimeticone dispersion tablets for treating the gaseous distention of gastrointestinal tract caused by indigestion and a preparation method thereof, and aims to make up the disadvantages in the prior art and provide a novel compound preparation, i.e. compound domperidone dimeticone dispersion tablets to patients and medical workers; wherein, the compound domperidone dimeticone dispersion tablets have swift disintegration, fast absorption and easy administration, and can increase the bioavailability and the blood concentration of drugs. Domperidone dimeticone is used as a raw material, auxiliary materials with specific types and proportions are added, and the mixture is pressed into the tablets according to the conventional technique of the preparation course.

The invention discloses an oral milk coagulant for treating infant thrush. The oral milk coagulant is prepared from the following components by weight: 150 million units of 10-20 million / ml nystatin, 8ml of medical 5% sodium bicarbonate, 0.5g of vitamin C, 250mg of vitamin B, 2ml of cod-liver oil, 10ml of liquid pectin, 1g of lactose and 0-0.2ml of traditional Chinese medicine extract. Compared with the prior art, the oral milk coagulant has the effects of simpleness in use, easiness for coating, lasting pasting effect of medicines at an infected part, long action time, rapid effect and high bioavailability; by adopting the oral milk coagulant, the problems of unprofessional operation of family numbers of patients in drug separation, waste of traditional Chinese medicines during a drug blending process and difficulty in drug application; clinical trials prove that the oral milk coagulant disclosed by the invention has a significant effect in treating infant thrush and has no toxic and side effects through the selection of proper components in proper proportion.

The invention relates to an ilaprazole enteric orally disintegrating tablet and a preparation method thereof. The ilaprazole enteric orally disintegrating tablet comprises the components in percentage by weight as follows: 1-5% of ilaprazole, 8-10% of hollow pill core, 2-5% of stabilizer, 10-15% of isolating layer, 15-20% of enteric coating, 35-70% of filler and 10-20% of disintegrating agent. The invention provides the ilaprazole enteric orally disintegrating tablet which is small in grain size, quick to absorb, high in bioavailability, good in taste, easy to swallow, good in disintegrating effect, strong in compressibility and convenient for patients to take, and the preparation method thereof.

The invention belongs to the technical field of medicine and discloses a Chinese medicinal preparation for treating recurrent oral ulceration. The Chinese medicinal preparation for treating recurrent oral ulceration is prepared from the following raw materials: 20 parts of natural indigo, 18 parts of sessile stemona root, 15 parts of humifuse euphorbia herb, 15 parts of curcuma zedoaria, 12 parts of snake gourd fruit, 12 parts of barbed skullcap herb, 12 parts of amur cork tree bark, 10 parts of platycodon grandiflorus, 10 parts of gardenia, 10 parts of liquorice, 10 parts of astragalus, 10 parts of ophiopogon japonicus, 7 parts of dark plum fruit, 7 parts of prunella vulgaris, 5 parts of cortex albiziae, 5 parts of muskmelon seed, 5 parts of uncaria tomentosa and 3 parts of mulberry leaf. The Chinese medicinal preparation disclosed by the invention has a short treatment course for treating recurrent oral ulceration and has a high total effective rate; after the Chinese medicinal preparation is applied and recurrent oral ulceration is healed, recurrent oral ulceration is difficult to recur moreover, the process is simple, the production cost is reduced and the economical burden of a patient is reduced.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition for clinically preventing, nursing and treating trichomonas vaginitis. The pharmaceutical composition is prepared from the following medicines in parts by weight: 30 parts of rhizoma anemarrhenae, 28 parts of the roots of red-rooted salvia, 27 parts of honeysuckles, 25 parts of plantain herb, 25 parts of polygonum cuspidatum, 23 parts of angelica sinensis, 22 parts of folium mori, 22 parts of cutch, 20 parts of hawthorn, 18 parts of scutellaria baicalensis, 16 parts of radix stemonae, 14 parts of peach kernels, 12 parts of golden cypress, 10 parts of radix bupleurim, 10 parts of rehmannia, 9 parts of felwort, 8 parts of platycodon grandiflorum, 6 parts of the roots of Chinese pulsatilla, 5 parts of rhizoma atractylodis, 3 parts of corydalis tuber, 2 parts of radix achyranthis bidentatae, 2 parts of flowers carthami and 1 part of ligusticum wallichii. The pharmaceutical composition prepared by the invention is a pure traditional Chinese medicine which is low in toxic and side effects and good in curative effect, and can be used for clinically preventing, nursing and treating trichomonas vaginitis.

The invention relates to a medicine composite for curing combined external head injuries in clinical nursing. The medicine composite is prepared from following raw materials in parts by weight: 27 parts of prepared rehmannia root, 25 parts of Chinese angelica, 25 parts of radix paeoniae rubrathe, 22 parts of curcuma rhizome, 22 parts of dandelion, 20 parts of radish seed, 20 parts of patrinia herb, 18 parts of plantain seed, 18 parts of Japanese eupatorium, 17 parts of eucommia, 15 parts of campsis grandiflora, 15 parts of cassia twig, 15 parts of perilla leaf, 15 parts of Chinese yam, 13 parts of banksia rose, 12 parts of mulberry, 12 parts of poria cocos, 12 parts of licorice, 10 parts of saposhnicovia divaricata, 10 parts of trichosanthes root, 10 parts of cyperus rotundus, 10 parts of albizia bark, 8 parts of ligusticum wallichii, 8 parts of edible fungus, 7 parts of barbat skullcap, 5 parts of almond, 5 parts of phellodendron, 3 parts of prunella vulgaris and 3 parts of wolfberry. The materials mentioned above are used together to bring out the best in each other, the medicine composite has a rapid curative effect on the combined external head injuries and the application prospect is vast.

The invention belongs to the field of medicaments, and particularly relates to an emulsion of N-(2-(2-amine) oxyethio-based benzothiazole-6-)-2-formamide derivatives and a preparation method thereof. The invention aims at providing a suitable dosage form for increasing the N-(2-(2-amine) oxyethio-based benzothiazole-6-)-2-formamide derivatives, especially for solubility and bioavailability of CBTA (carboxyl benzene triazole), and finally the inventor prepares the N-(2-(2-amine) oxyethio-based benzothiazole-6-)-2-formamide derivatives into the emulsion which is provided for clinic application.According to the prepared emulsion, the particle size of the disperse phase is 0.05mum-1mum, the average particle size is 150nm-400nm, so that the prepared emulsion belongs to submicroemulsion; the dispersion degree of liquid drops in the emulsion is large, the absorption of medicines and the acting of medicine effect are fast and the bioavailability is high.

The present invention provides a Chinese medicine perlingual preparation for relieving cough and reducing sputum and its preparation method. It is made up by using scrophularia root as main raw material and using tangerine peel as auxiliary raw material through a certain preparation process. Said invention can be made into the dosage forms of lozenge, sugar-coated lozenge and perlingual pills.

The invention discloses a preparation with the new efficacies of activating blood circulation and removing blood stasis and a preparation method thereof. The preparation comprises the following components in parts by weight: 250-350 parts of motherwort, 150-250 parts of angelica sinensis, 100-200 parts of ligusticum wallichii, 80-120 parts of sodium alginate, 25-35 parts of hydroxy propyl methyl cellulose, 145-270 parts of glucan, 30-70 parts of calcium hydrophosphate, 50-70 parts of sodium carboxymethyl starch, 10-30 parts of lauryl sodium sulfate and 3-5 parts of micro-powder silica gel. The preparation is prepared into a dispersing tablet, and the preparation method comprises the following steps: extracting and preparing a medicinal material into dry paste powder, preparing the dry paste powder into an inclusion compound and then further preparing the inclusion compound into the dispersing tablet. In the preparation disclosed by the invention, the solubility of an insoluble drug in the dry paste powder extracted from the medicinal material can be significantly improved, the disintegration time is shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost, low in energy consumption and easy to realize industrial production.

The invention belongs to the technical field of medicines and discloses a nymphaea tetragona chewable tablet which adopts fine powder of nymphaea tetragona petals as active ingredients, is assisted by other pharmaceutic adjuvants and comprises a filling agent, a flavoring agent, a lubricating agent. The chewable tablet has the advantages of good taste, convenient administration, fast absorption, fast effect and high bioavailability, and has better application prospect.

The invention discloses a traditional Chinese medicinal preparation having wind and cold dispelling, muscle and tendon relaxing and blood circulation activating effects, and a preparation method thereof. The preparation comprises, by weight, 60-80 parts of Radix Aconiti Preparata, 90-110 parts of Radix Aconiti Kusnezoffii Preparata, 130-150 parts of Radix Stephaniae Tetrandrae, 60-80 parts of Divaricate Saposhnikovia Root, 60-80 parts of Himalayan Teasel Root, 60-80 parts of Achyranthes bidentata, 60-80 parts of cassia twig, 60-80 parts of Radix Clematidis, 130-150 parts of Geranium wilfordii Maxim., 50-100 parts of sodium alginate, 20-40 parts of hydroxypropyl methyl cellulose, 70-150 parts of pregelatinized starch, 30-60 parts of crospovidone, 10-20 parts of sodium dodecyl sulfate and 4-6 parts of aerosol. The preparation is processed to prepare a dispersing tablet. The preparation method is carried out to extract medicinal materials in order to prepare dry paste powder, the dry paste powder is processed to prepare a clathrate, and the clathrate is processed to the prepare the dispersing tablet. The above product obviously improves the dissolvability of insoluble medicines in the dry paste powder of the medicinal material extract, shortens the disintegration time and increases the bioavailability. The preparation method has the advantages of simple process, low production cost, low energy consumption, and easiness in realization of industrial production.

The invention relates to a traditional Chinese medicine composition for treating cerebral apoplexy. The composition is prepared from the following raw materials in parts by weight: 35 parts of ginseng, 33 parts of white hyacinth beans, 30 parts of gingko leaves, 25 parts of epimedium, 25 parts of forsythia, 25 parts of gastrodia tuber, 22 parts of myrrh, 22 parts of prepared rehmannia, 20 parts of pagodatree flower buds, 20 parts of spina date seeds, 18 parts of fructus aurantii, 18 parts of rhizoma calami, 18 parts of fructus trichosanthis, 17 parts of eleutherococcus senticosus, 17 parts of polygala tenuifolia willd, 17 parts of perilla leaves, 17 parts of ligusticum wallichii, 17 parts of radix salviae miltiorrhizae, 15 parts of semen raphani, 15 parts of gynostemma, 10 parts of globe amaranth, 10 parts of radix curcumae, 10 parts of angelica, 8 parts of eucommia, 8 parts of radix astragali, 5 parts of tuckahoe, 5 parts of cortex albiziae and 5 parts of taraxacum. The traditional Chinese medicine composition provided by the invention has a remarkable effect in treating sequelaes of cerebral stroke and has a broad application prospect.

The invention discloses a plant-derived compound organic growth regulating tablet, belonging to the field of fertilizers. The plant-derived compound organic growth regulating table comprises, by weight, 10 to 15 parts of Radix Aucklandiae, 10 to 15 parts of coix seeds, 10 to 15 parts of chicken's gizzard-membranes, 5 to 10 parts of coptis, 15 to 20 parts of licorice roots, 30 to 35 parts of hydroxypropyl methyl cellulose, 20 to 30 parts of acrylic resin, etc. The compound organic growth regulating tablet provided by the n has a wide application range and can effectively improve the survival rate of crops in a seedling stage; a slow-release agent is fast in action, long in action time and easy to absorb; since the medicines are micronized, the solubility of the medicines is obviously improved, so the bioavailability of the medicines is improved, the usage amounts of the medicines are reduced, the resources of Chinese herbal medicines are saved, and the toxic and side effects of the chemical agent are lowered; the raw materials mentioned above are easily available; the preparation cost for the tablet is low; and resistance development can be delayed, so the service life of the chemical agent is prolonged. The organic growth regulating tablet provided by the invention is balanced and comprehensive in nutrition.

The invention belongs to the technical field of medicines, and discloses a medicinal composition for treating hyperglycemia and hyperlipidemia. The composition is prepared from the following raw materials in parts by weight: 30 parts of hawthorn, 30 parts of typhae pollen, 28 parts of gordon euryale, 28 parts of platycodon grandiflorum, 27 parts of dodder, 26 parts of burdock root, 25 parts of rhizoma anemarrhenae, 25 parts of yam, 25 parts of lalang grass rhizome, 23 parts of Chinese angelica, 23 parts of chrysanthemum, 20 parts of purslane, 20 parts of salviae miltiorrhizae, 20 parts of radix ophiopogonis, 17 parts of atractylodes, 15 parts of mulberry leaves, 15 parts of dendrobe, 15 parts of polished round-grained rice, 15 parts of medlar, 15 parts of radices trichosanthis, 10 parts of red peony root, 10 parts of prepared ginger, 10 parts of cornus officinalis, 9 parts of polygonatum odoratum, 9 parts of myrrh, 9 parts of kudzuvine root, 5 parts of rhizoma chuanxiong, 5 parts of prepared rehmannia, and 5 parts of schisandra chinensis. The medicinal composition can effectively treat hyperglycemia and hyperlipidemia, does not have toxic or side effect, is simple in process and low in price, can reduce the economic burden of patients, and has a wide application prospect.

The invention discloses a drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and a preparation method thereof. The drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria comprises the following components by weight: 100 parts of erythromycin estolate, 50-70 parts of sodium alginate, 40-50 parts of hydroxypropyl methyl cellulose, 150-190 parts of glucan, 30-50 parts of sodium carboxymethyl starch, 30-40 parts of sodium dodecyl sulfate, and 5-7 parts of aerosol. The preparation method provided by the invention employs sodium alginate inclusion technology to prepare erythromycin estolate into an inclusion compound, and then the main drug inclusion compound is further prepared into dispersible tablets. The erythromycin estolate product prepared by the method provided by the invention has increased solubility, high dissolution rate, shortened disintegration time, and improved bioavailability and curative effect. The preparation method has the characteristics of simple process, low production cost, low energy consumption, and easy realization of industrial production.

The invention belongs to the technical field of medicine preparations, and in particular relates to an ornidazole orally disintegrating tablet preparation and a preparation method of the ornidazole orally disintegrating tablet preparation. The ornidazole orally disintegrating tablet is prepared from the following ingredients in percentage by weight: 50-80 % of ornidazole, and 20-50 % of an excipient, wherein the excipient comprises one or more of a disintegrating agent, an adhesive, a corrigent, a lubricant and a glidant. The ornidazole orally disintegrating tablet provided by the invention has the advantages that the disintegrating is rapid, the mouthfeel is excellent, no gritty sense exists, no discomfort exists, the stability is stable, the curative effects are reliable, the effect is timely, the absorption is rapid, the bioavailability is greatly increased, the demands of patients are conformed, in addition, the preparation process is simple, and is suitable for large-scale production, etc.

The invention relates to a pure traditional Chinese medicine preparation for dental ulcers. The pure traditional Chinese medicine preparation is prepared from the following raw materials: 15 parts of white atractylodes rhizome, 15 parts of rhizoma zingiberis, 15 parts of uncaria rhynchophylla, 12 parts of curcuma zedoary, 12 parts of portulaca grandiflora, 12 parts of golden cypress, 10 parts of fructus gardeniae, 10 parts of licorice root, 10 parts of astragalus membranaceus, 10 parts of radix ophiopogonis, 7 parts of smoked plum, 7 parts of spica prunellae, 5 parts of cortex albiziae, 5 parts of muskmelon seeds and 3 parts of folium mori. When the pure traditional Chinese medicine preparation is used for treating the dental ulcers, the treatment course is short; the total effective rate is high; and the dental ulcers are difficult to relapse after being cured. In addition, the pure traditional Chinese medicine preparation is simple in process, so that the production cost is lowered; and the economical burden of a patient is lightened.