Chinese traditional medicine soft capsule for treating chronic cholecystitis and gallstone, and its preparation

Abstract

The soft Chinese medicine capsule for treating chronic cholecystitis and gall-stone consists of soft capsule coating and contained matter. The contained matter includes dementholized mint oil and medicinal supplementary material capable of being mixed homogeneously with dementholized mint oil, and the supplementary material is selected from polyglycol-400, Tween-80, glycerine, vegetable oil, etc. The preparation has effectively controlled volatilization of dementholized mint oil, stable quality, homogeneously distributed medicine component, fast leaching, high bioavailability, and well masking of the special smell of dementholized mint oil for easy taking.

Description

Technical field: [0001] The invention relates to a soft capsule preparation with peppermint oil as an active ingredient and a preparation method thereof, belonging to the technical field of medicine. Background technique: [0002] Chronic cholecystitis is a clinical common disease, frequently-occurring disease, belongs to the category of "biliary distension" and "hypochondriac pain" in traditional Chinese medicine. The pathogenesis is due to emotional depression or poor diet, excessive food greasy or disturbed blood, leading to stagnation of liver and gallbladder qi. Blood stasis caused by stagnation of qi, blood stasis and heat transformation, heat and spleen dampness accumulate, and become the disease of liver and gallbladder damp heat. If gallbladder qi is blocked, it will cause pain, if bile backflows, it will turn yellow, if the heat accumulation does not dissipate, it will suppurate and fester, and the heat and toxin will proliferate and expand into blood vessels. If...

AI Technical Summary

Problems solved by technology

Although the clinical application of Danshu Capsules is very good, as the main drug is volatile oil capsules, there are the following obvious shortcomings: (1) because the peppermint oil in the Danshu prescription is easy to volatilize, so it is made into common hard In the case of capsule preparations, the active ingredients will inevitably be lost during the granulation process, which will affect the curative effect

Although the content of Danshu Capsules is controlled by content determination, the loss in the preparation process has at least caused a waste of resources

(2) Because peppermint oil has a specific fragrance, common hard capsule preparations cannot be well concealed, so it brings certain inconvenience to the patient's medication

(3) The ordinary hard capsule preparation of Danshu is not well sealed, and the mint oil is volatile, resulting in drug instability

In addition, for volatile oils, there are disadvantages such as uneven content distribution and low bioavailability after granulating them into hard capsules