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Nymphaea tetragona chewable tablet and preparation method thereof

A water lily and chewable tablet technology, applied in the field of medicine, can solve the problems of low utilization rate of medicinal active ingredients, unable to achieve medicinal purposes, inconvenient for patients to swallow, etc., and achieves easy industrial production, low cost and fast onset of action Effect

Inactive Publication Date: 2010-07-21
日照金禾生化集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But existing water lily has all adopted the form of direct drug administration, wherein the utilization rate of medicinal active ingredient is low, can't reach the expected medicinal purpose, and because the reason of medicine itself makes the user very inconvenient when using, also is not convenient for patient swallowing, in order to develop the medicinal resources of water lily, there is an urgent need for a way to effectively use it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Harvest petals in summer, wash, remove impurities, and dry in the sun. Soak water lily petals in 6 times 50°C water for 2-3 hours, filter the separated extract with a 16-20 mesh screen, concentrate the filtrate, reduce the volume by 1-1.5 times, let the filtrate cool, and add 95% ethanol 1 times the amount, stir to produce a large amount of precipitate, place and filter, wash the precipitate with 95% ethanol, combine the starch liquid and filtrate, recover the ethanol under reduced pressure to form a thin paste, then concentrate at normal pressure to a thick paste, dry it into powder for later use, and collect the extract The rate is around 50%.

[0022] Get 100 grams of the above-mentioned water lily flower fine powder, 800 g of sucrose, 4 g of aspartame, spray and add 15 g of water, mix evenly and send to the granulation machine granules, dry the granules at 60 ° C, add 3 g of magnesium stearate to the dry granules, and uniformly Sent to tablet press to make water li...

Embodiment 2

[0024] Harvest petals in summer, wash, remove impurities, and dry in the sun. Soak water lily petals in 6 times 50°C water for 2-3 hours, filter the separated extract with a 16-20 mesh screen, concentrate the filtrate, reduce the volume by 1-1.5 times, let the filtrate cool, and add 95% ethanol 1 times the amount, stir to produce a large amount of precipitate, place and filter, wash the precipitate with 95% ethanol, combine the starch liquid and filtrate, recover the ethanol under reduced pressure to form a thin paste, then concentrate at normal pressure to a thick paste, dry it into powder for later use, and collect the extract The rate is around 50%.

[0025] Get 100 grams of the above-mentioned water lily fine powder, 800 grams of microcrystalline cellulose, 4 grams of acesulfame-K, add 15 grams of water to the spray, mix them evenly and feed them into granules, and dry the granules at 60° C. Sent to tablet press to make water lily chewable tablets.

Embodiment 3

[0027] Harvest petals in summer, wash, remove impurities, and dry in the sun. Soak water lily petals in 6 times 50°C water for 2-3 hours, filter the separated extract with a 16-20 mesh screen, concentrate the filtrate, reduce the volume by 1-1.5 times, let the filtrate cool, and add 95% ethanol 1 times the amount, stir to produce a large amount of precipitate, place and filter, wash the precipitate with 95% ethanol, combine the starch liquid and filtrate, recover the ethanol under reduced pressure to form a thin paste, then concentrate at normal pressure to a thick paste, dry it into powder for later use, and collect the extract The rate is around 50%.

[0028] Get 100 grams of the above-mentioned water lily flower fine powder, 800 g of mannitol, 4 g of protein sugar, spray and add 15 g of water, mix them evenly and send them to the granulation mechanism, dry the granules at 60 ° C, add 3 g of talcum powder to the dry granules, and send them evenly to the press The tablet mac...

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Abstract

The invention belongs to the technical field of medicines and discloses a nymphaea tetragona chewable tablet which adopts fine powder of nymphaea tetragona petals as active ingredients, is assisted by other pharmaceutic adjuvants and comprises a filling agent, a flavoring agent, a lubricating agent. The chewable tablet has the advantages of good taste, convenient administration, fast absorption, fast effect and high bioavailability, and has better application prospect.

Description

Technical field: [0001] The invention relates to a chewable tablet with water lily flower as the main raw material and a preparation method thereof, belonging to the technical field of medicine. Background technique: [0002] Uyghur medicine water lily is the dried flower of Nymphaeaceae Snow White Water Lily, which produces dampness and coldness. It has the functions of dampening the brain and calming the nerves, clearing heat and nourishing the heart, reducing heat and nourishing the liver, reducing inflammation and relieving cough, moisturizing the throat and quenching thirst, clearing away heat and detoxification, and calming the nerves. It is mainly used for acute and chronic convulsions in children, headaches, heat sensations, and coughs caused by fever. It has a long history of folk medicine in Uyghur, and it is the main component of single or compound antiviral drugs commonly used in Uyghur medicine. [0003] Indications for dry-heat or biliary diseases, such as dry...

Claims

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Application Information

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IPC IPC(8): A61K36/62A61P25/04A61P29/00A61P11/14A61P31/12A61K9/20A61K133/00
Inventor 秦大伟张娟
Owner 日照金禾生化集团股份有限公司
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