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Preparation and use of dragon's blood disintegrants

A technology of dispersible tablets and dried blood, which is applied in the field of quick-acting pharmaceutical preparations for promoting blood circulation and removing blood stasis and its preparation, can solve the problems of slow dissolution, slow onset of effect, limited therapeutic effect, etc., and achieve the effect of excellent disintegration speed

Inactive Publication Date: 2005-02-23
胡少勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low bioavailability of dragon's blood preparations commonly used in clinical practice, its therapeutic effect is often limited; in addition, the treatment of patients with cardiovascular and cerebrovascular diseases generally requires drugs to take effect quickly, and the common main preparations are limited due to slow dissolution and slow onset of action

Method used

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  • Preparation and use of dragon's blood disintegrants
  • Preparation and use of dragon's blood disintegrants

Examples

Experimental program
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example 1

[0050] Example 1. Prescription of Xuejie Dispersible Tablets:

[0051] Dried blood 300g

[0052] CMS-Na 25g

[0053] Microcrystalline Cellulose 100g

[0054] L-HPC 25g

[0055] Crosslinked CMC-Na 25g

[0056] Micronized silica gel 6g

[0057] Magnesium Stearate 4.5g

[0058] 80% ethanol appropriate amount

[0059] Made into 1000 pieces

[0060] Preparation method: weigh dried blood according to the above-mentioned prescription, put it in a particle ball mill and grind it for 2 hours, take it out and pass through a 120-mesh sieve, weigh microcrystalline cellulose, L-HPC, cross-linked CMC-Na, 2 / 3 according to the prescription amount Prescribed amount of CMS-Na, mixed evenly; soft material made of 95% ethanol, granulated with 24 mesh, dried at 60°C, granulated, added the remaining amount of CMS-Na, micronized silica gel and magnesium stearate, pressed into tablets Instantly.

[0061] Each tablet of this product contains 300mg of dried blood, ...

example 2

[0062] Example 2. Prescription of Xuejie Dispersible Tablets:

[0063] Dragon Blood Extract 50g

[0064] Low Substitution-Hydroxypropyl Cellulose 20g

[0065] Microcrystalline Cellulose 100g

[0066] Lactose 100g

[0067] 5% PVP K30 Solution 100g

[0068] Talc powder 6g

[0069] Made into 1000 pieces

[0070] Preparation method: take the dried blood and add 5 times the volume of ethanol, ultrasonically extract, 30 minutes each time, extract 2 parts, combine the extracts, recover under reduced pressure, and obtain the dried blood extract; weigh the dried blood extract and lactose according to the above preparation prescription , placed in an airflow mill and crushed, passed through a 200-mesh sieve, added microcrystalline cellulose and low-substituted-hydroxypropyl cellulose, mixed evenly, and mixed with 5% PVP K30 Soft material made from ethanol solution, passed through 18-mesh sieve, dried at 60°C, granulated at 20-mesh, added with tal...

Embodiment 3

[0071] Embodiment 3, Xuejie dispersible tablet preparation prescription:

[0072] Dried blood 600g

[0073] CMS-Na 45g

[0074] PVPP 90g

[0075] Microcrystalline Cellulose 100g

[0076] Crosslinked CMC-Na 25g

[0077] 95% right amount

[0078] Micronized silica gel 10g

[0079] Made into 1000 pieces

[0080] Preparation method: refer to the prescription, weigh dried blood and cross-linked CMC-Na, put it in a particle ball mill and grind it for 2 hours, take it out and pass it through a 120-mesh sieve, weigh the prescribed amount of PVPP and microcrystalline cellulose, mix and granulate by wet method In the machine, mix for 2 minutes, use 95% ethanol as a soft material, granulate with a 30-mesh sieve, and dry at 80°C; pass the dry granules through a 20-mesh sieve for granulation, add the prescribed amount of CMS-Na and micro-powder silica gel to the dry granules, and press into tablets , packaged to obtain the blood-drying dispersib...

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Abstract

A dispersing tablet of Dragon's blood for treating the acute cardiovascular and cerebrovascular diseases is disclosed.

Description

technical field [0001] The invention relates to a quick-acting medicinal preparation for promoting blood circulation and removing blood stasis and its preparation, in particular to a quick-acting traditional Chinese medicine preparation made of herbal medicine as the main medicine and adding necessary auxiliary materials. Background technique [0002] Cardiovascular and cerebrovascular diseases have always been the enemy that threatens human health. With the improvement of material living standards and changes in lifestyle in my country, and my country's gradual entry into an aging society, the threat of cardiovascular and cerebrovascular diseases is becoming more and more serious. Statistics from epidemiology show that the prevalence, morbidity, and mortality of cardiovascular and cerebrovascular diseases in my country have continued to rise in the past 30 years; there are 5-6 million stroke patients in the country; the number of new cases is about 180,000-200,000 per year ;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P9/00
Inventor 胡少勇袁解乾
Owner 胡少勇
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