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Drug preparation for infantile diarrhea

A pharmaceutical preparation and a technology for infantile diarrhea, which are applied in the field of traditional Chinese medicine, can solve the problems of increasing patient suffering, poor syndrome differentiation and prescription, and insignificant curative effect, and achieve the effects of low cost, remarkable and reliable curative effect, and simple preparation.

Inactive Publication Date: 2013-11-27
冷飞燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional Chinese medicine prescriptions in the prior art lack dialectics, and the formulas are outdated. The dialectical prescriptions for rotavirus infection belonging to the category of damp-heat and epidemic toxins in traditional Chinese medicine are not good enough. The treatment cycle is long, the symptoms are not strong, the curative effect is not obvious, and even bring side effects to patients , increasing the pain of patients, finding effective and safe medicines from natural medicines has become an important clinical direction for children with diarrhea

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A pharmaceutical composition for treating infantile diarrhea, which is prepared from the following raw materials in weight ratio:

[0021] 30 parts of white lentils, 25 parts of yam, 25 parts of red peony, 25 parts of curcuma, 25 parts of dandelion,

[0022] 22 parts of radish seed, 22 parts of Atractylodes macrocephala, 20 parts of pomegranate peel, 20 parts of fungus, 18 parts of almond,

[0023] Poria cocos 18 parts, coix seed 18 parts, licorice 15 parts, windproof 15 parts, Cyperus cyperi 15 parts,

[0024] 15 parts of Andrographis paniculata, 10 parts of dried ginger, 10 parts of purslane, 10 parts of Citrus aurantium, 10 parts of tangerine peel,

[0025] 7 parts of Burnet, 7 parts of Chuanxiong, 5 parts of Cortex Phellodendri, 3 parts of Lycium barbarum, and 3 parts of hawthorn.

[0026] Its preparation and taking method of the pharmaceutical composition of the present invention are: take the crude drug (proportioning unit: gram) of above-mentioned parts by weig...

Embodiment 2

[0032] 1. Toxicity test

[0033] In this experiment, healthy SD rats were used, and the dose gradient of the drug prepared in Example 1 was administered orally at 0.05 mg / kg and 1.0 mg / kg. The drug was administered continuously for 30 days, and the rats were observed during the administration period and 1 week after drug withdrawal. Animal growth status, activity diet, hematology, blood biochemistry, organ tissue structure and urine routine were not significantly affected, indicating that the clinical medication is safe and reliable.

[0034] 2. Effects on castor oil-induced diarrhea model in mice

[0035] Get 60 ICR mice, half male and half male, randomly divided into model control group, Smecta group, the present invention (medicine of embodiment 1) group, the model group was given equal volume of normal saline, once a day, for three consecutive days. 40 minutes after the last administration, each animal was given 0.2ml castor oil by intragastric administration. The mice w...

Embodiment 3

[0039] A total of 70 children with acute and chronic diarrhea were tested, including 36 females and 34 males, aged between 6 months and 2 years old. The above patients were randomly divided into two groups: 35 cases in the treatment group and 35 cases in the control group;

[0040] Diagnostic criteria

[0041] According to the diagnostic criteria for infantile diarrhea in the "Practical Pediatric Diagnosis and Treatment Standards", with the pale tongue and white coating as the main basis for the type of spleen deficiency, all patients were diagnosed as infantile diarrhea.

[0042] treatment method

[0043] The treatment group took the medicine prepared in Example 1 orally, 1 g each time for <1 year old, 2 g each time for 1-2 years old, and 3 g each time for 2-3 years old, three times a day.

[0044] The control group took Smecta orally, 1g each time for <1 year old, 2g each time for 1-2 years old, and 3g each time for 2-3 years old, all three times a day.

[0045] A course of...

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PUM

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Abstract

The invention relates to a drug preparation for infantile diarrhea. The drug preparation is prepared from the following raw materials: white hyacinth bean, Chinese yam, red peony root, zedoray rhizome, dandelions, radish seed, largehead atractylodes rhizome, pomegranate rinds, agarics, almonds, Indian bread, semen coicis, liquorice, divaricate saposhnikovia root, nutgrass galingale rhizome, common andrographis herb, dried gingers, purslane herb, orange fruit, dried tangerine peel, garden burnet root, Sichuan lovage rhizome, amur corktree bark, barbary wolfberry fruit and hawthorns. The drugs are used jointly and bring out the best in each other, so that the drug preparation takes an effect on infantile diarrhea quickly and has extensive application prospects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical preparation for treating infantile diarrhea with Chinese herbal medicines as raw materials. Background technique [0002] Infantile diarrhea (also known as viral diarrhea) is a common disease, frequently-occurring disease, mainly popular in spring, autumn and winter every year. In 1973, "rotavirus" (rotavirus) was found in the epithelial cells of Australian children's biopsies in clinical medicine, "shaped like a wheel". The virus invades the epithelial cells of the small intestine, shortening and shedding the villi, resulting in loss of intestinal function. Mucosa disaccharidase activity decreases, xylose and sucrose in the intestinal cavity are hydrolyzed and absorbed, and are decomposed by bacteria to produce organic acids, resulting in increased intestinal osmotic pressure, a large amount of water and electrolytes entering t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/12
Inventor 尹永红
Owner 冷飞燕
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