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Compound domperidone dimethicone dispersible tablet and its preparation method

A technology of domperidone and simethicone, applied in the directions of pill delivery, digestive system, drug combination, etc.

Inactive Publication Date: 2008-11-19
北京利乐生制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no dosage form of domperidone on the market in the domestic market, but many pharmaceutical companies, government departments, scientific research institutes and other institutions are conducting research on this drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Domperidone 10g

[0022] Simethicone 125g

[0023] Calcium hydrogen phosphate 125g

[0024] Microcrystalline Cellulose 137.5g

[0025] Croscarmell Starch Sodium 19g

[0026] Cross-linked polyvinylpyrrolidone 8g

[0027] Starch slurry 7g (calculated as starch)

[0028] Magnesium Stearate 3g

[0029] A total of 1000 pieces were made

[0030] Preparation:

[0031] First, crush the above-mentioned materials through a 100-mesh sieve, take simethicone and add it to the absorbent calcium hydrogen phosphate for later use (1); after fully mixing domperidone, microcrystalline cellulose, (1), add an appropriate amount of starch slurry Make soft material, granulate with 16-mesh sieve, dry at 60°C for 3-4 hours, granulate with 16-mesh sieve, add disintegrant cross-linked sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone and lubricant stearic acid Magnesium, after mixing, compressed into dispersible tablets.

Embodiment 2

[0033] prescription:

[0034] Domperidone 10g

[0035] Simethicone 125g

[0036] Calcium hydrogen phosphate 250g

[0037] Lactose 10.5g

[0038] Pregelatinized starch 42g

[0039] Microcrystalline Cellulose 48g

[0040] Low-substituted hydroxypropyl cellulose 18g

[0041] Micronized silica gel 1.5g

[0042] A total of 1000 pieces were made

[0043] Preparation:

[0044] First, the above-mentioned materials were crushed through a 100-mesh sieve, and simethicone was added to the absorbent calcium hydrogen phosphate for later use (1); Domperidone, lactose, pregelatinized starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose Elements, (1) After fully mixing evenly, adjust the pressure and press into dispersible tablets.

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PUM

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Abstract

The invention relates to compound domperidone dimeticone dispersion tablets for treating the gaseous distention of gastrointestinal tract caused by indigestion and a preparation method thereof, and aims to make up the disadvantages in the prior art and provide a novel compound preparation, i.e. compound domperidone dimeticone dispersion tablets to patients and medical workers; wherein, the compound domperidone dimeticone dispersion tablets have swift disintegration, fast absorption and easy administration, and can increase the bioavailability and the blood concentration of drugs. Domperidone dimeticone is used as a raw material, auxiliary materials with specific types and proportions are added, and the mixture is pressed into the tablets according to the conventional technique of the preparation course.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation, in particular to a compound domperidone simethicone dispersible tablet for treating gastrointestinal flatulence caused by indigestion and a preparation method thereof. Background technique [0002] Domperidone is a peripheral dopamine receptor blocker, acting directly on the gastrointestinal wall, increasing the tension of the lower esophageal sphincter, preventing gastroesophageal reflux, enhancing gastric motility, promoting gastric emptying, coordinating gastric and duodenal motility, inhibiting Nausea, vomiting, and can effectively prevent bile reflux without affecting gastric secretion. This product is not easy to pass through the blood-cerebrospinal fluid barrier, and has no inhibitory effect on dopamine receptors in the brain. Therefore, it has no extrapyramidal and other neurological and mental adverse reactions. Because the surface tension of this product is small, it can change the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61K9/20A61K47/34A61K47/38A61P1/08A61K47/20A61K47/26
Inventor 王蒙
Owner 北京利乐生制药科技有限公司
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