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Dropping pill with fentanyl as main active component and preparation method thereof

A technology of nidi pills and active ingredients, applied in the field of new pharmaceutical preparations, can solve the problems of unresolved pain, affecting patients' life and work, brokerage and time waste, etc.

Inactive Publication Date: 2010-07-07
北京利乐生制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In daily life, pain is already a common disease with a high incidence rate. People often adopt traditional treatment, so that the pain cannot be cured, which causes a waste of time and money, and affects the life and work of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Fentanyl 50mg

[0020] PEG4000 4.5g

[0021] PEG9000 25g

[0022] A total of 1000 capsules were made

[0023] Preparation:

[0024] Mix fentanyl, PEG4000, and PEG9000 evenly, heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the dripper, and drop it into Put it in simethicone oil at -5°C, after forming, filter, separate, and wipe clean to get it.

Embodiment 2

[0026] prescription:

[0027] Fentanyl citrate (calculated as fentanyl) 100mg

[0028] PEG6000 25g

[0029] Polyoxyl 40 Stearate 24g

[0030] A total of 1000 capsules were made

[0031] Preparation:

[0032] Take fentanyl, PEG6000, polyoxyl 40 stearate and mix evenly, heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill making machine, keep it warm at 80°C, Select the dripper and drop it into the simethicone oil at -10°C. After forming, filter, separate, and wipe clean.

Embodiment 3

[0034] prescription:

[0035] Fentanyl 200mg

[0036] PEG400 4.5g

[0037] PEG6000 25g

[0038] A total of 1000 capsules were made

[0039] Preparation:

[0040] After mixing fentanyl and polyoxyl 40 stearate evenly, heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill making machine, keep it warm at 80°C, and select the droplet Drop into the liquid paraffin at -5°C, filter, separate, and wipe clean after forming.

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PUM

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Abstract

The invention relates to a dropping pill with fentanyl as a main active component and a preparation method thereof. The dropping pill adopts the fentanyl and salts or hydrates which can be accepted in terms of pharmacy as the active components. The invention aims at providing a new preparation namely the fentanyl dropping pill for vast patients and medical workers. The fentanyl dropping pill has the following characteristics: the disintegration is quick, the bioavailability of the pill can be enhanced, the curative effect of the pill can be completely exerted, and adverse reactions can be reduced; the fentanyl dropping pill is convenient not only for children to take, but also for old people to take with reduced dosage; the preparation method is simple; in addition, the fentanyl dropping pill is suitable for mass production and is convenient for carrying, storing as well as transporting. The fentanyl and the salts or the hydrates which can be accepted in terms of pharmacy are adopted as the active components and some accessories of specified categories and in specified proportions are added, so as to prepare the dropping pill according to the conventional technology in terms of pharmaceutics.

Description

technical field [0001] A drop pill with fentanyl as the main active ingredient and a preparation method thereof. The invention relates to a novel pharmaceutical preparation, in particular to a drop pill of fentanyl and its pharmaceutically acceptable salt and hydrate for pain relief and a preparation method thereof. Background technique [0002] Since ancient times, pain has been a very complex physiological phenomenon, and it is also the symptom with the highest incidence rate among human diseases. Everyone experiences and feels pain personally throughout their lives. According to the medical theory of the motherland: there is an unbearable pain called pain inside and outside the body, and it is called pain accompanied by some soreness. Western medicine theory believes that the sensation caused by pathological abnormalities in the nerve endings and stimulation conduction system to the brain is called pain. [0003] Pain disorders involve a wide range of patients and invo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4468A61P25/04
Inventor 李宝齐
Owner 北京利乐生制药科技有限公司
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