Entecavir soft capsule and its preparation method
A technology of entecavir and soft capsules, which is applied in the field of entecavir soft capsules for the treatment of hepatitis B and its preparation, and can solve the problems that many pharmaceutical factories, government departments, scientific research institutes and other institutions are conducting research work on the drug
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Embodiment 1
[0021] prescription:
[0022] Entecavir 0.5g
[0023] PEG400 190g
[0024] Propylene glycol 9.5g
[0025] A total of 1000 capsules were made
[0026] Preparation:
[0027] First heat about 80% PEG400 to 40-60°C, add entecavir, stir to dissolve, then add the prescribed amount of propylene glycol, stir evenly, then add the remaining amount of PEG400 to obtain a clear solution; adjust the temperature control system of the dropping pill machine, Heat the dropper of the dropping pill machine and keep it at 50-90°C, cool the temperature of the condensing agent and keep it at -5-40°C; adjust the size of the dropper to control the weight of the soft capsule content, and press it to get it.
Embodiment 2
[0029] prescription:
[0030] Entecavir 1g
[0031] PEG400 190g
[0032] Propylene glycol 7g
[0033] Tween-80 2
[0034] A total of 1000 capsules were made
[0035] Preparation:
[0036] First heat about 80% PEG400 to 40-60°C, add entecavir, stir to dissolve, then add the prescribed amount of propylene glycol and Tween-80, stir well, then add the remaining amount of PEG400 to obtain a clear solution; adjust the dropping pill machine The temperature control system makes the dropper temperature of the dropping pill machine heated and kept at 50-90°C, the temperature of the condensing agent is cooled and kept at -5-40°C, and the size of the dripper is adjusted to control the weight of the soft capsule content, pressing , that is.
Embodiment 3
[0038] prescription:
[0039] Entecavir 1g
[0040] Edible vegetable oil 494.5
[0041] Beeswax 2.5g
[0042] Tween-80 2.0g
[0043] A total of 1000 capsules were made
[0044] Preparation:
[0045] Grind Entecavir into ultra-fine powder, add it to edible vegetable oil, stir to make it evenly suspended, add the prescribed amount of beeswax and Tween-80, and continue to stir to obtain a good oily suspension; adjust the temperature control of the dropping pill machine system, to heat and maintain the dropper temperature of the dropping pill machine at 50-90°C, and cool and maintain the temperature of the condensing agent at -5-40°C; adjust the size of the dripper to control the weight of the contents of the soft capsule, and compress, that is have to.
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