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Memantine hydrochloride dispersable table and its preparing method

A technology of memantine hydrochloride and dispersible tablets, which is applied in the fields of pharmaceutical formulations, active ingredients of amines, drug delivery, etc., and can solve the problems that many pharmaceutical factories, government departments, scientific research institutes and other institutions are conducting research work on the drug

Inactive Publication Date: 2005-12-21
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no dosage form of memantine hydrochloride on the market in the domestic market, but many pharmaceutical companies, government departments, scientific research institutes and other institutions are conducting research on this drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] prescription:

[0029] Component Weight %

[0030] Memantine Hydrochloride 8

[0031] Lactose 18

[0032] Pregelatinized starch 25

[0033] Microcrystalline Cellulose 35

[0034] Low-substituted hydroxypropyl cellulose 7

[0035] Polyvinylpyrrolidone aqueous solution 6 (calculated as polyvinylpyrrolidone)

[0036] Micronized silica gel 1

[0037] Preparation:

[0038] First, the above-mentioned materials are crushed through a 100-mesh sieve, and memantine hydrochloride, lactose, pregelatinized starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose are thoroughly mixed, and then an appropriate amount of polyvinylpyrrolidone aqueous solution is added to make it Soft material, granulated with 24 mesh sieve, dried at 60°C for 5 hours, granulated with 20 mesh sieve after drying, mixed with micronized silica gel, adjusted the pressure, and pressed into memantine hydrochloride dispersible tablets.

Embodiment 2

[0040] prescription:

[0041] Component Weight %

[0042] Memantine Hydrochloride 10

[0043] Mannitol 37.5

[0044] Microcrystalline Cellulose 35

[0045] Croscarmellose Sodium Starch 6

[0046] Cross-linked polyvinylpyrrolidone 3

[0047] Starch slurry 7 (calculated as starch)

[0048] Magnesium Lauryl Sulfate 1.5

[0049] Preparation:

[0050]First, the above-mentioned materials were crushed through a 100-mesh sieve, memantine hydrochloride, mannitol, and microcrystalline cellulose were fully mixed, and an appropriate amount of starch slurry was added to make a soft material, granulated with a 16-mesh sieve, and dried at 60°C for 3 - After 4 hours, granulate with a 16-mesh sieve, add disintegrant cross-linked sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone and lubricant magnesium lauryl sulfate, mix well, and press into memantine hydrochloride dispersible tablets .

Embodiment 3

[0052] prescription:

[0053] Component Weight %

[0054] Memantine Hydrochloride 10

[0055] Mannitol 30

[0056] Microcrystalline Cellulose 45

[0057] Croscarmellose Sodium Starch 5

[0058] Aspartame 2.5

[0059] Lemon essence 1.0

[0060] Talc 1.5

[0061] Starch slurry 5 (calculated as starch)

[0062] Preparation:

[0063] First, the above-mentioned materials were crushed through a 100-mesh sieve, and memantine hydrochloride, mannitol, and microcrystalline cellulose were fully mixed, and then an appropriate amount of starch slurry was added to make a soft material, granulated with a 16-mesh sieve, and dried at 80°C for 3 Hours later, granulate with a 16-mesh sieve, add disintegrating agent cross-linked sodium carboxymethyl starch, flavoring agent aspartame, lemon flavor, lubricant talcum powder, after mixing, press into memantine hydrochloride dispersible tablets.

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PUM

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Abstract

The present invention relates to a new type medicine preparation memantine hydrochloride dispersing tablet and its preparation method. Its composition includes (by wt%) 0.5-95% of memantine hydrochloride, 20-90% of filling agent, 5-30% of disintegrant agent, 1-30% of corrective agent, 0.1-5% of lubricating agent and 0.5-5% of metarchon agent.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation, in particular to a memantine hydrochloride dispersible tablet for treating senile dementia and a preparation method thereof. Background technique [0002] Senile dementia (Alzheimer's disease) is one of the common diseases of the elderly, mainly manifested as memory loss and cognitive impairment, etc., and is a progressive neurodegenerative disorder. A large number of research data at home and abroad show that one out of every ten elderly people shows different degrees of dementia symptoms, which seriously affects people's health and quality of life. The cost of research related to Alzheimer's in the United States is second only to AIDS. According to reports, the incidence rate of Alzheimer's disease in the United States accounts for about 10% among the elderly around the age of 65, and accounts for about 47% among the elderly over the age of 85. It has become the first disease after heart d...

Claims

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Application Information

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IPC IPC(8): A61K31/13
CPCA61K9/0056A61K31/13
Inventor 严轶东蔡金巧
Owner FUKANGREN BIO PHARMA
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