Compound gabapentin mecobalamin dispersible tables and preparation method thereof
A technology of gabapentin methylcobalamin and gabapentin methylcobalamin, which is applied in the field of new pharmaceutical preparations and can solve problems such as the research work of the medicine being carried out by government departments, scientific research institutes and other institutions
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[0021] Example 1:
[0022] prescription:
[0023] Gabapentin 300g
[0024] Methylcobalamin 0.5g
[0025] Mannitol 25g
[0026] Microcrystalline cellulose 137.5g
[0027] Croscarmellose Sodium Starch 19g
[0028] Cross-linked polyvinylpyrrolidone 8g
[0029] Starch slurry 7g (based on starch)
[0030] Magnesium stearate 3g
[0031] 1000 pieces in total
[0032] Preparation:
[0033] First crush the above-mentioned materials through a 100-mesh sieve, mix gabapentin, mecobalamin, mannitol, microcrystalline cellulose, and mix well, add an appropriate amount of starch slurry to make a soft material, and granulate with a 16-mesh sieve at 60℃ After drying for 3-4 hours, use a 16-mesh sieve to granulate, add disintegrating agent croscarmellose sodium, cross-linked polyvinylpyrrolidone and lubricant magnesium stearate, and after mixing, press to form gabapentin and methylcobalamin dispersion sheet.
Example Embodiment
[0034] Example 2:
[0035] prescription:
[0036] Gabapentin 300g
[0037] Methylcobalamin 0.5g
[0038] Lactose 10.5g
[0039] Pregelatinized starch 42g
[0040] Microcrystalline cellulose 48g
[0041] Low-substituted hydroxypropyl cellulose 18g
[0042] Micro powder silica gel 1.5g
[0043] 1000 pieces in total
[0044] Preparation:
[0045] First crush the above-mentioned materials through a 100-mesh sieve. After fully mixing gabapentin, lactose, pregelatinized starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose, adjust the pressure and press to make gabapentin. Amine dispersible tablets.
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