Drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and preparation method thereof

A bacterial infection, acute and chronic technology, applied in the field of medicine, can solve the problems of not being able to exert the drug effect quickly, alleviating the symptoms of chronic patients, low bioavailability, etc. Effect

Inactive Publication Date: 2017-10-13
广西大海阳光药业有限公司
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the problems of long disintegration time, low dissolution rate, poor absorption and low bioavailability of the existing erythromycin tablets, which cannot quickly exert the drug effect and quickly alleviate the symptoms of chronic patients, etc., and provides a disintegrating Fast solution speed, good dissolution, high dispersion, easy absorption, high bioavailability, fast onset, easy to take for the treatment of acute and chronic bacterial infections caused by sensitive bacteria and its preparation method, which solves the current problem of relying on red The problems mentioned above in the existence of mymycin tablets

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and preparation method thereof
  • Drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and preparation method thereof
  • Drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] A preparation method for preparing dispersible tablets for the treatment of acute and chronic bacterial infections caused by sensitive bacteria, comprising the steps of:

[0067] T1: Weigh the following components by weight: Erythromycin 2000g, sodium alginate 1000g, hydroxypropyl methylcellulose 800g, dextran 3000g, sodium carboxymethyl starch 600g, sodium lauryl sulfate 600g 100g of micropowder silica gel, passed through a 100-mesh sieve, and set aside;

[0068] T2: Preparation of Etoerythromycin inclusion complex: Dissolve Etoerythromycin in 4000g of absolute ethanol to make Etoerythromycin absolute ethanol liquid, take sodium alginate and put it in a batching tank, add 10000g of water and heat to 45°C to make it Dissolve to obtain sodium alginate solution, slowly add Etoerythromycin absolute ethanol solution into the sodium alginate solution, stir while adding, the stirring speed is 50rpm, keep stirring at 45°C for 4h, put it at room temperature and set aside Place...

Embodiment 2

[0075] A preparation method for preparing dispersible tablets for the treatment of acute and chronic bacterial infections caused by sensitive bacteria, comprising the steps of:

[0076] T1: Weigh the following components by weight: Erythromycin 2000g, sodium alginate 1400g, hydroxypropyl methylcellulose 1000g, dextran 3800g, sodium carboxymethyl starch 1000g, sodium lauryl sulfate 800g 1. Micropowder silica gel 140g, passed through a 100-mesh sieve, set aside;

[0077] T2: Preparation of Etoerythromycin Inclusion Compound: Dissolve Etoerythromycin in 6000g of absolute ethanol to make Etoerythromycin absolute ethanol liquid, take sodium alginate and put it in a batching tank, add 14000g of water and heat to 65°C to make it Dissolve to obtain sodium alginate solution, slowly add Etoerythromycin anhydrous ethanol solution into sodium alginate solution, stir while adding, stirring speed is 100rpm, keep stirring at 65°C for 2h, put it at room temperature and then set aside Place i...

Embodiment 3

[0084] A preparation method for preparing dispersible tablets for the treatment of acute and chronic bacterial infections caused by sensitive bacteria, comprising the steps of:

[0085] T1: Weigh the following components by weight: Erythromycin 2000g, sodium alginate 1200g, hydroxypropyl methylcellulose 900g, dextran 3400g, sodium carboxymethyl starch 800g, sodium lauryl sulfate 700g 120g of micropowder silica gel, passed through a 100-mesh sieve, and set aside;

[0086] T2: Preparation of Etoerythromycin inclusion compound: Dissolve Etoerythromycin in 5000g of absolute ethanol to make Etoerythromycin absolute ethanol liquid, take sodium alginate and put it in a batching tank, add 12000g of water and heat to 55°C to make it Dissolve to obtain sodium alginate solution, slowly add Etoerythromycin anhydrous ethanol solution into sodium alginate solution, stir while adding, stirring speed is 80rpm, keep stirring at 55°C for 3h, put it at room temperature and place Place it at 6°C...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria and a preparation method thereof. The drug for treatment of acute and chronic bacterial infection caused by sensitive bacteria comprises the following components by weight: 100 parts of erythromycin estolate, 50-70 parts of sodium alginate, 40-50 parts of hydroxypropyl methyl cellulose, 150-190 parts of glucan, 30-50 parts of sodium carboxymethyl starch, 30-40 parts of sodium dodecyl sulfate, and 5-7 parts of aerosol. The preparation method provided by the invention employs sodium alginate inclusion technology to prepare erythromycin estolate into an inclusion compound, and then the main drug inclusion compound is further prepared into dispersible tablets. The erythromycin estolate product prepared by the method provided by the invention has increased solubility, high dissolution rate, shortened disintegration time, and improved bioavailability and curative effect. The preparation method has the characteristics of simple process, low production cost, low energy consumption, and easy realization of industrial production.

Description

technical field [0001] The invention belongs to the field of medicines and relates to a medicine and a preparation method thereof, in particular to a medicine for treating acute and chronic bacterial infections caused by sensitive bacteria and a preparation method thereof. Background technique [0002] Erythromycin Erythromycin, English name Erythromycin Estolate, Chinese alias erythromycin propionate dodecyl sulfate, erythromycin propionate dodecyl sulfate, erythromycin sulfate laurate, odorless erythromycin dry Syrup, odorless erythromycin, this product is a macrolide antibiotic, which is the dodecyl sulfate of erythromycin propionate. Modern pharmacological studies have shown that Etoerythromycin has: (1) antibacterial effect, which can kill certain bacteria at high concentrations; Antibacterial activity; (3) It is also sensitive to Neisseria, Haemophilus influenzae, Bordetella pertussis, etc.; (4) It also has antibacterial activity against various anaerobic bacteria exc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61K47/36A61K47/38A61K47/20A61K47/04A61P31/04
CPCA61K9/2009A61K9/2013A61K9/205A61K9/2054A61K9/2059A61K31/7048
Inventor 黄大权唐新
Owner 广西大海阳光药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap