Amino acid type foam bacteriostatic hand sanitizer and preparation method thereof

Abstract

The invention discloses an amino acid type foam bacteriostatic hand sanitizer and a preparation method thereof.The hand sanitizer is prepared from, by weight, 0.1%-0.5% of a bacteriostatic agent climbazole, 4%-15% of an amino acid surfactant, 2%-18% of an ampholytic surfactant, 1%-15% of a nonionic surfactant, 1%-15% of a humectant, 0.01%-0.5% of a chelating agent, 0.1%-4% of a pH regulator and the balance water. 0.05-1% of essence, 0.1-1% of a preservative and the balance of water. The climbazole is applied to the hand sanitizer, and the climbazole is stable in property and low in price and toxicity under the action of light and heat; in the mixing process of climbazole and water, citric acid and lactic acid are added, the technical problem that climbazole is difficult to dissolve in water can be effectively solved, the dissolving speed is high, additional heating is not needed, and energy consumption can be effectively reduced; the prepared amino acid foam hand sanitizer has the advantages of being mild, low in irritation, good in antibacterial effect and good in low-temperature storage stability.

Description

Technical Field

[0001] The invention belongs to the technical field of hand sanitizer preparation, and particularly relates to an amino acid type foam antibacterial hand sanitizer and a preparation method thereof. Background Art

[0002] As traditional hand-washing products, soap and soap are easily exposed to the air and contaminated with bacteria, dust, etc., causing cross infection. As a substitute for traditional hand-washing products, hand sanitizer not only reduces the risk of cross infection, but also facilitates the addition of antibacterial agents to exert the antibacterial effect of hand sanitizer. Some antibacterial hand sanitizers on the market are AES hand sanitizers, which have strong degreasing power, and the skin is easy to dry after washing, which is irritating. AES surfactants have a false slippery feeling and need to be rinsed with water many times. There is still a risk of dioxane residue, which is not friendly to the environment and human health. Amino acid surfactants have the characteristics of low irritation, low toxicity, softness, good biodegradability, etc., which meet the various needs of consumers. Commonly used amino acid surfactants mainly include glycine, alanine, sarcosine, glutamic acid, methyl taurine, and glutamic acid type surfactants. Among them, glutamic acid type surfactants are more mild and low in irritation when used in formulas. Their hydrophilic head groups are large and difficult to thicken, and are suitable for use in foam hand sanitizers that do not require thickening.

[0003] Most of the antibacterial agents used in the antibacterial hand sanitizers on the market are trifluoromethane, quaternary ammonium salts, ethanol, etc., which are more irritating to human skin. Piroctone ethanolamine salt has low toxicity, but its aqueous solution is easy to color, light is easy to discolor and oxidize and decompose, and it is expensive, and its application is limited. Chinese patent CN108125812B discloses an amino acid foam antibacterial hand sanitizer. Although it has a relatively broad-spectrum antibacterial effect, it uses parachlorometaxylenol and salicylic acid as antibacterial agents. Parachlorometaxylenol has poor water solubility, and its compatibility with nonionic surfactants and methylcellulose can reduce its antibacterial activity, limiting the choice of surfactants. Salicylic acid is also more irritating to infants. Climbazole has good antibacterial effect, low toxicity, stable properties in light and heat, its aqueous solution is clear and transparent, and does not need to be stored in dark places, but the solubility of climbazole in water is low, and the system usually needs to be heated for a long time, and the energy consumption is large. Currently, climbazole is mostly used in shampoo products to inhibit Malassezia, and there is no product that uses climbazole in antibacterial hand soap.

[0004] On the other hand, most antibacterial hand sanitizers increase their antibacterial efficacy by creating an unsuitable growth environment for bacteria at too high or too low a pH value. However, too high a pH value is highly irritating to the skin. At too low a pH value, amino acid surfactants and antibacterial agents are easily precipitated, causing product instability and poor antibacterial effect. The development of amino acid antibacterial hand sanitizers is difficult.

[0005] Therefore, it is of great significance to develop an amino acid hand sanitizer suitable for climbing hormone. Summary of the invention

[0006] In view of the above problems, the object of the present invention is to provide an amino acid type foam antibacterial hand soap and a preparation method thereof.

[0007] The specific technical solutions are as follows:

[0008] An amino acid foam antibacterial hand soap comprises, by weight percentage, 0.1-0.5% of an antibacterial agent climbazole, 4-15% of an amino acid surfactant, 4-18% of an amphoteric surfactant, 1-15% of a nonionic surfactant, 1-15% of a moisturizing agent, 0.01-0.5% of a chelating agent, 0.1-4% of a pH regulator, 0.05-1% of an essence, 0.1-1% of a preservative, and the balance is water.

[0009] Furthermore, the amino acid surfactant is selected from at least one of sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium methyl lauroyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium lauroyl glutamate, sodium cocoyl glutamate, TEA cocoyl glutamate, and TEA lauroyl glutamate.

[0010] Furthermore, the amphoteric surfactant is selected from at least one of lauroamphopropyl betaine, cocamidopropyl betaine, lauroamphopropyl hydroxysulfonate, cocamidopropyl hydroxysulfonate, sodium lauroamphoacetate, and disodium lauroamphodiacetate.

[0011] Furthermore, the nonionic surfactant is decyl glucoside, the moisturizer is at least one of glycerin, butylene glycol, and propylene glycol, the chelating agent is disodium ethylenediaminetetraacetic acid, the pH adjuster is citric acid and lactic acid, and the preservative is PE9010.

[0012] Furthermore, the content of amino acid surfactant is 4-10%, the content of amphoteric surfactant is 2-12%, the content of nonionic surfactant is 2-12%, the content of moisturizing agent is 1-10%, the content of chelating agent is 0.05-0.2%, the content of pH regulator is 0.5-3%, the content of preservative is 0.2-0.8%, and the content of flavor is 0.2-1%.

[0013] A method for preparing an amino acid type foam antibacterial hand soap comprises the following steps: weighing climbazole into water accounting for two-thirds of the total amount by mass, adding citric acid and lactic acid, dissolving the climbazole until transparent at room temperature, sequentially adding an amino acid surfactant, a zwitterionic surfactant, a nonionic surfactant, a preservative, a moisturizer, a chelating agent, and a flavor, and stirring evenly; finally adding the remaining water, testing the pH value to be 4.3-5.0, stirring evenly, and then filling into a foam bottle.

[0014] The beneficial effects of the present invention are:

[0015] (1) The present invention applies climbazole to hand sanitizer. Climbazole has stable properties under the action of light and heat, and has low price and toxicity. In the process of mixing climbazole and water, citric acid and lactic acid are added, which can effectively solve the technical problem of its difficulty in dissolving in water. The dissolution speed is fast, no additional heating is required, and energy consumption can be effectively reduced.

[0016] (2) The hand sanitizer provided by the present invention is an amino acid hand sanitizer with good biodegradability.

[0017] Ethanol-free hand sanitizer and AES-based hand sanitizer have moderate degreasing power, are easy to rinse, and have lower irritation. (3) The amino acid hand sanitizer provided by the present invention achieves the product in

[0018] It is stable and does not precipitate at low temperature and low pH value, thus ensuring the effect of the antibacterial agent. The hand sanitizer provided by the invention can not only inhibit Staphylococcus aureus, but also effectively inhibit Escherichia coli and Candida albicans. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 Schematic diagram of the results of zein dissolution in different hand sanitizers. DETAILED DESCRIPTION

[0020] The following is a further description in conjunction with the accompanying drawings and embodiments, but the protection scope of the present invention is not limited thereto.

[0021] Examples 1-5

[0022] The raw material ratio is shown in Table 2, and the operation steps are the same as follows:

[0023] S1: Climbazole, deionized water accounting for two-thirds of the total amount, citric acid, and lactic acid were weighed according to the weight percentage in Table 1 and mixed thoroughly at room temperature for 30 minutes to make the system clear and transparent.

[0024] S2: sodium lauroyl glutamate, lauroylamidopropyl hydroxysulfobetaine, decyl glucoside, glycerin, PE9010 (a mixture of ethylhexylglycerin and phenoxyethanol), disodium ethylenediaminetetraacetic acid, and essence are added to the aqueous solution of climbazole prepared in step S1 in sequence, and stirred evenly; finally, the remaining water is added, and the pH value is tested to be 4.3-5.0, and the mixture is poured into a foam bottle after stirring evenly.

[0025] The main raw materials used in the examples are shown in Table 1.

[0026] Table 1 Summary of main raw materials used

[0027]

[0028]

[0029] Table 2 Summary of proportions of different embodiments

[0030]

[0031] Comparative Examples 1-5

[0032] The operation process is the same as that of Example 1-5, with some operating parameters changed, as shown in Table 3.

[0033] Table 3 Summary of the proportions of comparative examples 1-5

[0034]

[0035]

[0036] Comparative Example 6

[0037] The raw material compositions of Comparative Example 6 are the same as those of Example 1, except that the order of adding climbazole is different from that of Example 1. The operation steps are as follows:

[0038] S1: Weigh sodium lauroyl glutamate, lauramidopropyl hydroxysulfobetaine, decyl glucoside, glycerin, PE9010 (a mixture of ethylhexylglycerin and phenoxyethanol), disodium ethylenediaminetetraacetate, and flavor according to the weight percentage in Table 1, and stir evenly at room temperature to make the system clear and transparent.

[0039] S2: Add climbazole and citric acid to the aqueous solution prepared in step S1, stir at room temperature until it is basically dissolved, add the remaining deionized water, test the pH to be 4.3-5.0, stir evenly and put into a foam bottle.

[0040] Comparative Example 7

[0041] The raw materials of Comparative Example 7 are the same as those of Example 1, except that the order of addition of climbazole and the dissolution temperature of climbazole are different. The operation steps are as follows:

[0042] S1: Weigh sodium lauroyl glutamate, lauramidopropyl hydroxysulfobetaine, decyl glucoside, glycerin, PE9010 (a mixture of ethylhexylglycerin and phenoxyethanol), and disodium ethylenediaminetetraacetate according to the weight percentages in Table 1, and stir evenly at room temperature to make the system clear and transparent.

[0043] S2: Add climbazole and citric acid to the aqueous solution obtained in step S1, stir at 80°C until it is basically dissolved, cool to room temperature, add flavor and stir until clear, add the remaining deionized water, test the pH to be 4.3-5.0, stir evenly and put into a foam bottle.

[0044] Table 4 Comparison of Climbazole Melting Time of Example 1 and Comparative Examples 6-7

[0045]

[0046]

[0047] From the results in Table 4, it can be seen that dissolving climbazole and acidic substances in water first and then adding the remaining substances can significantly accelerate their dissolution rate, which is conducive to reducing energy consumption and improving production efficiency.

[0048] Stability test:

[0049] The stability of the above embodiments and comparative examples at different temperatures was investigated for 1 month. The results are shown in Table 5.

[0050] Table 5 Summary of stability results of products prepared in Examples 1-5 and Comparative Examples 1-5

[0051]

[0052] It can be seen from Table 5 that Comparative Example 1 is turbid and precipitated at a temperature below 0°C, and Comparative Example 2 is stratified at a temperature below 0°C, which is not conducive to the product stability of the antibacterial hand sanitizer and affects the use effect. The low-temperature stability of sodium lauroyl glutamate is poor when it is only matched with lauroyl amide propyl hydroxysulfonyl betaine or only matched with decyl glucoside. The zwitterionic surfactant of Comparative Example 3 is easily stratified and precipitated at low temperatures after being replaced with sodium lauroyl amphoacetate. Compared with sodium lauroyl amphoacetate, the combination of lauroyl amide propyl hydroxysulfonyl betaine and glutamic acid-type surfactant has better storage stability at low temperatures, and the formed micelle structure is more stable, uniformly dispersed in the system, inhibiting the precipitation of crystals and the stratification of the system, and ensuring the stability of the product. Examples 1 to 5 are matched with sodium lauroyl glutamate, lauroyl amide propyl hydroxysulfonyl betaine, and decyl glucoside, and are clear and transparent when stored at different temperatures for one month, which helps the product not to deteriorate during transportation and storage. In Comparative Example 4, the antibacterial agent was changed to piroctone ethanol ammonium salt, and the stability was reduced at low temperature, and crystals were easily precipitated; in Comparative Example 5, the antibacterial agent was changed to salicylic acid, and turbidity precipitated within one month of low-temperature storage. Under the same proportion of antibacterial agent replacement in Example 1, the stability of the combination of piroctone ethanol ammonium salt and salicylic acid with amino acid surfactant was not as good as climbazole.

[0053] Sensory evaluation:

[0054] 30 volunteers were recruited to test the above embodiments and commercially available hand sanitizers. The volunteers washed their hands according to their daily hand washing habits (without restrictions on the amount of hand sanitizer used, hand washing method, and flushing time). The volunteers evaluated the cleaning ability, foam performance, mildness, flushing performance, and moisturizing degree of the hand sanitizer in turn. The scoring standard adopted a 5-point system, and the average value was finally calculated. The higher the score, the better the sensory effect. The results are shown in Table 6.

[0055] Table 6 Sensory evaluation results of volunteers

[0056] Group Cleaning power Foam density Mildness Flushing performance Moisture Example 1 3.5 4.1 4.5 4.5 4.2 Example 2 3.7 4.0 4.3 4.5 4.1 Example 3 3.6 4.2 4.2 4.4 4.0 Example 4 3.8 3.6 4.5 4.3 4.1 Example 5 3.9 3.4 4.6 4.2 4.1 Commercially available AES hand sanitizer 1 4.2 4.2 3.0 3.5 3.2 Commercially available AES hand sanitizer 2 4.3 4.1 3.2 3.7 3.8

[0057] Table 6 shows that among the five indicators of hand sanitizer, the foam density of the volunteers is comparable to that of the commercial AES hand sanitizer, and the mildness, rinsing performance, and moisturizing degree are better than those of the commercial AES hand sanitizer. The cleaning power is lower than that of the commercial AES hand sanitizer, and the degreasing power of the amino acid surfactant is moderate. Compared with the strong degreasing power of AES, it is more gentle on the skin, and the hands are not easy to dry and peel after washing.

[0058] Example 6

[0059] Zein irritation test

[0060] Products with strong irritation are easier to dissolve zein than products with weak irritation. The amount of zein that can be dissolved per gram of different products can be measured by weighing method. The specific steps are as follows:

[0061] Weigh 0.10 g of zein and add it to 10% hand sanitizer (after dilution, 5 g), shake on a vortex oscillator for 20 minutes, dissolve on a shaker at 60 rpm for 3 hours to fully mix the zein and hand sanitizer, centrifuge at 5000 rpm for 10 minutes, then pour off the supernatant, bake the lower layer in an oven at 80°C until constant weight, and then weigh it. Figure 1 As shown, from Figure 1 It can be seen that compared with the amount of zein dissolved in the commercially available AES hand sanitizer, the amount of the amino acid antibacterial hand sanitizer in the present invention dissolved in zein is significantly lower, the effect of the amino acid antibacterial hand sanitizer on zein is weak, and the irritation to the skin is low.

[0062] Example 7

[0063] Antibacterial performance test

[0064] The antibacterial performance of the product was tested according to Appendix C of the national standard 15979-2002 "Sanitary Standards for Disposable Sanitary Products": "Product Bactericidal Performance, Antibacterial Performance and Stability Test". The results of the 2-minute antibacterial performance of each embodiment and commercially available product are shown in Table 7.

[0065] Table 7 Summary of antibacterial test results of products prepared in Examples 1-5

[0066] Group Staphylococcus aureus Escherichia coli Candida albicans Example 1 ＞99.9％ ＞99.9％ ＞99.9％ Example 2 ＞99.9％ ＞99.9％ ＞99.9％ Example 3 ＞99.9％ ＞99.9％ ＞99.9％ Example 4 ＞99.9％ ＞99.9％ ＞99.9％ Example 5 ＞99.9％ ＞99.9％ ＞99.9％ Commercially available AES hand sanitizer 1 ＞99.9％ 72.9％ 32.5％ Commercially available AES hand sanitizer 2 ＞99.9％ ＞99.9％ ＞99.9％

[0067] It can be seen from Table 7 in combination with the test results of Examples 1-5 and the commercially available AES hand sanitizer 1 that the hand sanitizer prepared in the present application has excellent antibacterial properties. It can not only effectively inhibit Staphylococcus aureus and Escherichia coli commonly found in daily life, but also has excellent antibacterial effects on Candida albicans, which is more difficult to inhibit.

[0068] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, a person skilled in the art may make non-creative modifications to the present embodiment as needed, but such modifications are protected by patent law as long as they are within the scope of the claims of the present application.

Claims

1. An amino acid type foam antibacterial hand soap, characterized in that: In percentage by weight, including 0.1-0.5% The antibacterial agent climbazole, 4-15% amino acid surfactant, 2-18% amphoteric surfactant, 1-15% nonionic surfactant, 1-15% moisturizer, 0.01-0.5% chelating agent, 0.1-4% pH Regulator, 0.05-1% flavor, 0.1-1% preservative, and the balance is water.

2. An amino acid type foam antibacterial hand sanitizer as claimed in claim 1, characterized in that: The amino acid surfactant is selected from at least one of sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium methyl lauroyl taurate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium lauroyl glutamate, sodium cocoyl glutamate, TEA cocoyl glutamate, and TEA lauroyl glutamate.

3. An amino acid type foam antibacterial hand soap as claimed in claim 2, characterized in that: The amphoteric surfactant is selected from at least one of lauroamphopropyl betaine, cocamidopropyl betaine, lauroamphopropyl hydroxysulfobetaine, cocamidopropyl hydroxysulfobetaine, sodium lauroamphoacetate, and disodium lauroamphodiacetate.

4. An amino acid type foam antibacterial hand sanitizer as claimed in claim 3, characterized in that: The nonionic surfactant is decyl glucoside, the moisturizing agent is at least one of glycerin, butylene glycol and propylene glycol, the chelating agent is disodium ethylenediaminetetraacetic acid, the pH adjusting agents are citric acid and lactic acid, and the preservative is PE9010.

5. An amino acid type foam antibacterial hand sanitizer as claimed in claim 1, characterized in that: The content of amino acid surfactant is 4-10%, the content of amphoteric surfactant is 2-12%, the content of nonionic surfactant is 2-12%, the content of moisturizing agent is 1-10%, and the content of chelating agent is 0.05%-0.2%. The content of pH adjuster is 0.5-3%, the content of preservative is 0.2-0.8%, and the content of flavor is 0.2-1%.

6. A method for preparing the amino acid type foam antibacterial hand sanitizer as claimed in claim 4, characterized in that: The method comprises the following steps: weighing climbazole into water accounting for two-thirds of the total amount by weight, adding citric acid and lactic acid, dissolving the climbazole until transparent at room temperature, sequentially adding an amino acid surfactant, a zwitterionic surfactant, a nonionic surfactant, a preservative, a moisturizer, a chelating agent and an essence, and stirring evenly; finally adding the remaining water, testing the pH value to be 4.3-5.0, stirring evenly and then filling into a foam bottle.

Images