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Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof

A kind of apricot-flavored rabbit ear wind and effervescent technology, applied in the field of vaginal effervescent tablets, can solve the problems of slow onset of action and low blood drug concentration

Inactive Publication Date: 2006-11-22
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to develop a kind of effervescent tablet preparation directly used in the vagina in order to overcome the shortcomings of low local blood drug concentration and slow onset of action in the oral preparation of apricot rabbit ear wind

Method used

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  • Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof
  • Vaginal effervescence tablet of Ainsliaea fragrans and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] (1) Preparation of Xingxiang Rabbit's Ear Wind Extract: Take Xingxiang Rabbit's Ear Wind medicinal material, wash it, add 10 times the amount of water, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.1 to 1.2 (60°C) clear paste, add ethanol to make the alcohol content 70%, let it stand overnight, take the supernatant together, wash the precipitate twice with 70% ethanol, combine the washing liquid and the supernatant, and recover the ethanol And concentrated into a thick paste, placed in a vacuum oven and dried under reduced pressure at low temperature to form a dry paste.

[0075] (2) Preparation of Xingxiang Rabbit Earfeng Effervescent Tablets:

[0076] Weigh raw materials according to the following prescription ratio:

[0077] Apricot rabbit ear air-dried extract 1 part

[0078] Anhydrous citric acid 0.45 parts

[0079] Sodium bicarbonate 0.45 parts

[0080] Starch 0.14 parts

[00...

Embodiment 2

[0087] (1) Preparation of Xingxiang Rabbit's Ear Wind Extract: Take Xingxiang Rabbit's Ear Wind medicinal material, wash it, add 10 times the amount of water, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.1 to 1.2 (60°C) clear paste, add ethanol to make the alcohol content 70%, let it stand overnight, take the supernatant together, wash the precipitate twice with 70% ethanol, combine the washing liquid and the supernatant, and recover the ethanol And concentrated into a thick paste, placed in a vacuum oven and dried under reduced pressure at low temperature to form a dry paste.

[0088] (2) Preparation of Xingxiang Rabbit Earfeng Effervescent Tablets:

[0089] Weigh raw materials according to the following prescription ratio:

[0090] Apricot rabbit ear air-dried extract 1 part

[0091] Anhydrous citric acid 0.58 parts

[0092] Sodium bicarbonate 0.58 parts

[0093] Starch 0.18 parts

[00...

Embodiment 3

[0100] (1) Preparation of Xingxiang Rabbit's Ear Wind Extract: Take Xingxiang Rabbit's Ear Wind medicinal material, wash it, add 10 times the amount of water, decoct three times, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.1 to 1.2 (60°C) clear paste, add ethanol to make the alcohol content 70%, let it stand overnight, take the supernatant together, wash the precipitate twice with 70% ethanol, combine the washing liquid and the supernatant, and recover the ethanol And concentrated into a thick paste, placed in a vacuum oven and dried under reduced pressure at low temperature to form a dry paste.

[0101] (2) Preparation of Xingxiang Rabbit Earfeng Effervescent Tablets:

[0102] Weigh raw materials according to the following prescription ratio:

[0103] Apricot rabbit ear air-dried extract 1 part

[0104] Anhydrous citric acid 0.7 parts

[0105] Sodium bicarbonate 0.7 parts

[0106] Starch 0.225 parts

[010...

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Abstract

The invention relates to effervescent tablets for treating vaginal inflammation, wherein the preparation is prepared from Ainsliasa fragrans Champ. through extraction, then mixing the obtained dried concrete with auxiliary materials by a weight ratio of 1:1-6, and the auxiliary materials include effervescent excipient, bulking agent, surface active agent, crumbling agent, lubricating agent and bonding agent.

Description

technical field [0001] The invention relates to a local Chinese medicine preparation for treating gynecological inflammation, in particular to a vaginal effervescent tablet made from the plant Chinese herbal medicine Xingxiang rabbit's ear wind. The invention also relates to a preparation method of the medicine. Background technique [0002] Inflammation of the female reproductive system is a common and frequently-occurring disease in gynecology. It has been reported that among the 600 million women in my country, especially 82% of married women suffer from various degrees of gynecological inflammation. Inflammation mostly occurs in the lower reproductive tract, such as vulvitis, vaginitis and cervicitis, and can also invade the upper reproductive tract, that is, the internal genitalia, causing pelvic inflammatory disease, which seriously affects the quality of life of the majority of sick women. Surveys have shown that chronic cervicitis and cervical erosion are closely r...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/20A61K9/46A61P15/00A61P15/02
Inventor 张爱华王晖肖小华陈梅荣尧享华徐丽瑛郑国安胡丹张锐
Owner 江西省药物研究所
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