Clindamycin metronidazole vagina effervescent tablet and its preparing method and use

A technology of clindamycin and metronidazole, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, etc., can solve the problem that drugs cannot fully reach the vagina, affect the effect of drug treatment, and the foam is not long-lasting. and other problems, to achieve the effect of favorable drug distribution, easy normal activities, and large foaming volume

Inactive Publication Date: 2005-03-02
程月发 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The resulting vaginal effervescent tablet disintegrates quickly and has many foams, but there is a defect that the foam is not durable, and the medicine cannot fully reach the folds of the vagina, thereby affecting the therapeutic effect of the medicine

Method used

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  • Clindamycin metronidazole vagina effervescent tablet and its preparing method and use
  • Clindamycin metronidazole vagina effervescent tablet and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Clindamycin 1250g

[0035] Metronidazole 1000g

[0036] Tartaric acid 1240g

[0037] Sodium bicarbonate 1350g

[0038] Microcrystalline cellulose 600g

[0039] Hypromellose 140g

[0040] Starch 500g

[0041] Sodium Lauryl Sulfate 120g

[0042] Magnesium stearate 120g

[0043]An appropriate amount of 5% ethanol solution of polyvinylpyrrolidone is used for granulation. Make it into 10000 pieces.

[0044] Preparation method: Mix half of clindamycin, metronidazole, microcrystalline cellulose, starch, hypromellose, sodium lauryl sulfate and sodium bicarbonate according to the prescription amount, and mix with 5% polyvinylpyrrolidone granulate with ethanol solution, and dry at 50-60°C; mix evenly half the amount of clindamycin, metronidazole, microcrystalline cellulose, starch, hypromellose, sodium lauryl sulfate and tartaric acid according to the prescription amount, Granulate with 5% polyvinylpyrrolidone ethanol solution, dry at 50-60°C; mix the above two kinds of ...

Embodiment 2

[0046] Clindamycin 2500 parts

[0047] Metronidazole 2000 parts

[0048] Tartaric acid 1380 parts

[0049] Sodium bicarbonate 1500 parts

[0050] Microcrystalline cellulose 800 parts

[0051] Hypromellose 150 parts

[0052] Starch 600 parts

[0053] Sodium Lauryl Sulfate 200 parts

[0054] Magnesium stearate 180 parts

[0055] An appropriate amount of 5% ethanol solution of polyvinylpyrrolidone is used for granulation. Make it into 10000 pieces.

[0056] Preparation method: adopt the same method as in Example 1 to prepare. The tablet weight of the obtained vaginal effervescent tablet is about 0.98g / tablet.

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Abstract

The vagina effervescent tablet has the salt or ester of clindamycin and metronidazole as active component and is prepared via a common tablet making process. The present invention features that the said effervescent tablet contains hydroxypropyl methyl cellulose as adhesive. Compared with conventional effervescent tablet, the present invention has the advantages of greater foam amount, fine and lasting foams, homogeneous distribution of effective medicine component, long duration, raised medicine curative effect, simple preparation process, stable quality and being suitable for industrial production.

Description

Technical field: [0001] The invention relates to a clindamycin compound, a clindamycin-metronidazole vaginal effervescent tablet, a preparation method thereof and an application in medical treatment. Background technique: [0002] Clindamycin is a lincomycin antibiotic with strong antibacterial activity and broad antibacterial spectrum. It has obvious antibacterial effect, and also has bactericidal effect on most anaerobic bacteria, chlamydia, mycoplasma, Plasmodium falciparum and Toxoplasma gondii. This product acts on the 50S subunit of the ribosome of sensitive bacteria to prevent the extension of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Clindamycin is generally a bacteriostatic drug, but it also has a bactericidal effect on highly sensitive bacteria at high concentrations. It is widely used clinically to treat infections caused by aerobic gram-positive bacteria and various anaerobic bacteria. [0003] Metronidazole is a metronida...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/46A61K31/7056A61P15/02
Inventor 程月发王国勤周文艳盛四龙
Owner 程月发
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