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Gynecologic vaginal effervescent tablets and its prepn. method

An effervescent tablet and vaginal technology, applied to the field of Funing vagina effervescent tablet and its preparation, can solve the problems of easy deterioration of suppository base, difficult storage and transportation, influence on drug release, etc. fast effect

Inactive Publication Date: 2006-03-29
河北联合制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The external preparations that have been used clinically are suppositories at present, but the suppository matrix is ​​easy to deteriorate and seriously affects the release of the drug, thereby affecting the performance of the curative effect. Especially in summer, due to the high temperature, the suppository deteriorates faster and is difficult to store and transport. Therefore, a new method is needed. dosage form to improve its dosage form shortcomings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Effect of Funing Vaginal Effervescent Tablets on Mouse Ear Swelling Induced by Xylene

[0043] Test animals: 50 mice

[0044] Experimental grouping: According to body weight, they were randomly divided into the high-dose group of Funing vaginal effervescent tablets, the medium-dose group of Funing vaginal effervescent tablets, the low-dose group of Funing vaginal effervescent tablets, the group of Funing vaginal effervescent tablets, and the blank control group. Wherein the Funing vaginal effervescent tablet middle-dose group and the Funing suppository group use the same amount of active ingredients, and the preparation method of the effervescent tablet adopts the preparation method of Example 7 below.

[0045] Test method: the medication group applied the drug on both sides of the left ear of the mouse, the blank group applied the same amount of normal saline, half an hour later, applied xylene 0.05ml to the same part of the right ear of the mouse, and kille...

Embodiment 2

[0048] Example 2: Effect of Funing Vaginal Effervescent Tablets on Experimental Vaginitis in Rabbits

[0049] Test animals: 50 male rabbits

[0050] Test grouping: same as embodiment 1

[0051] Test method: After two days of routine feeding, use the inoculation needle first, and then use the inoculation loop to inoculate and inoculate continuously at 2-4cm in the vaginal opening for 24 hours, then press 10 -2 Diluted Candida albicans, and do a vaginal smear test three days later. After microscopic examination, it was found that Candida albicans were all positive, indicating that the modeling was successful. Then administered vaginally, and the blank control group was given normal saline. For 7 consecutive days, animals were dissected, with no change as 0 points; mild congestion, a small amount of secretions as 1 point; moderate congestion, edema, and more secretions as 2 points; severe congestion, edema, excessive secretions, mucous membrane Erosion was scored as 3 points....

Embodiment 3

[0055] prescription:

[0056] Funing Dry Extract Powder 700g

[0057] Tartaric acid 180g

[0058] Sodium bicarbonate 150g

[0059] Magnesium Stearate 10g

[0060] Preparation method: Weigh the prescribed amount of Funing dry extract powder, tartaric acid, sodium bicarbonate, magnesium stearate 20-40 mesh, mix well, and press into 1000 tablets.

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PUM

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Abstract

A vaginal effervescent tablet ''Funing'' contains active components (40-85 Wt%), acid source (5-35), CO2 source (5-25), lubricant (0.5-5) and adhesive (0-3). Its advantages are quickly taking its high curative effect, no damage to vaginal mucosa, and low by-effect.

Description

technical field [0001] The invention relates to a Funing vaginal effervescent tablet and a preparation method thereof. Background technique [0002] Gynecological inflammation is a common disease and frequently-occurring disease, and it is easy to repeat. According to the survey: about 150 to 200 million women of childbearing age in my country, about 41% of women suffer from gynecological inflammation in varying degrees, and the incidence rate of married women is as high as 70%. With the development of economy and the improvement of people's living standards, people With the enhancement of health awareness, women pay more and more attention to their own health. [0003] Funing suppository (see "Ministry of Traditional Chinese Medicine 20 Volumes", standard number WS3-B-3816-98) is composed of Sophora flavescens, Cortex Phellodendri, Scutellaria baicalensis, Curcuma, clam shell powder, red lead, catechu, frankincense, myrrh, Composed of pig bile powde...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K31/045A61K35/413A61K35/56A61K9/20A61K9/46A61P15/02A61K35/618
Inventor 李清娟孙煦文李彦辉郭文敏陈卫平梁亚丽
Owner 河北联合制药有限公司
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