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Miconazole nitrate compound vaginal extended-release effervescent tablets and preparation method thereof

A miconazole nitrate compound and technology of miconazole nitrate, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of slow vaginitis effect, achieve good curative effect, mild and non-irritating effect , quick effect

Inactive Publication Date: 2015-12-02
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when miconazole nitrate is used alone to treat vaginitis, the symptoms of vaginitis caused by fungi are slow.

Method used

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  • Miconazole nitrate compound vaginal extended-release effervescent tablets and preparation method thereof
  • Miconazole nitrate compound vaginal extended-release effervescent tablets and preparation method thereof
  • Miconazole nitrate compound vaginal extended-release effervescent tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]A compound miconazole nitrate sustained-release vaginal effervescent tablet, the effervescent tablet comprises: 1 part of miconazole nitrate, 20 parts of Corydalis Corydalis, 15 parts of mountain cucumber, 40 parts of Sophora flavescens, and catechu 35 parts, 60 parts of half leaves, 30 parts of Hydrangea, 30 parts of white fresh skin, 35 parts of Polygonum multiflorum, 50 parts of Artemisia argyi leaves, 5 parts of sodium alginate, 5 parts of polyethylene oxide, 5 parts of fumaric acid, 3 parts of sodium carbonate , 4 parts of sodium bicarbonate, 1 part of sodium lauryl sulfate, 5 parts of powdered sugar, and 0.5 part of polysorbate.

[0039] A preparation method of miconazole nitrate compound vaginal sustained-release effervescent tablet, comprising the following steps:

[0040] 1) Prepare materials, prepare materials according to the described components and parts by weight, miconazole nitrate is pulverized through a 120 mesh sieve, sodium alginate, polyethylene oxide...

Embodiment 2

[0050] A compound miconazole nitrate sustained-release vaginal effervescent tablet, the effervescent tablet comprises: 2 parts of miconazole nitrate, 22 parts of Corydalis Corydalis, 18 parts of mountain cucumber, 43 parts of Sophora flavescens, and catechu 4 parts , 6 parts of sodium bicarbonate, 1.5 parts of sodium lauryl sulfate, 9 parts of powdered sugar, and 0.7 part of polysorbate.

[0051] A preparation method of miconazole nitrate compound vaginal sustained-release effervescent tablet, comprising the following steps:

[0052] 1) Prepare materials, prepare materials according to the described components and parts by weight, miconazole nitrate is pulverized through a 120 mesh sieve, sodium alginate, polyethylene oxide, fumaric acid, sodium carbonate, sodium bicarbonate, lauryl sulfuric acid Sodium, powdered sugar, and polysorbate were respectively crushed through an 80-mesh sieve;

[0053] 2) Extraction of active ingredients of traditional Chinese medicine raw material...

Embodiment 3

[0062] A compound miconazole nitrate sustained-release vaginal effervescent tablet, the effervescent tablet has components and parts by weight: 3 parts of miconazole nitrate, 25 parts of corydalis, 20 parts of mountain cucumber, 45 parts of Sophora flavescens, and catechu 40 parts, 70 parts of half leaves, 40 parts of Hydrangea, 40 parts of white fresh skin, 40 parts of Polygonum multiflorum, 60 parts of mugwort leaves, 10 parts of sodium alginate, 10 parts of polyethylene oxide, 10 parts of fumaric acid, 5 parts of sodium carbonate , 10 parts of sodium bicarbonate, 2 parts of sodium lauryl sulfate, 10 parts of powdered sugar, 1 part of polysorbate.

[0063] A preparation method of miconazole nitrate compound vaginal sustained-release effervescent tablet, comprising the following steps:

[0064] 1) Prepare materials, prepare materials according to the described components and parts by weight, miconazole nitrate is pulverized through a 120 mesh sieve, sodium alginate, polyethyl...

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Abstract

The invention discloses miconazole nitrate compound vaginal extended-release effervescent tablets and a preparation method thereof. The effervescent tablets comprise miconazole nitrate, Corydalis tuber, Tricyrtis root, lightyellow Sophora root, cutch, Wilson's passion flower, root of Silene tenuis, root-bark of shaggy-fruited dittany, fleeceflower root, Chinese mugwort leaf, sodium alginate, polyoxyethylene, fumaric acid, sodium carbonate, sodium bicarbonate, lauryl sodium sulfate, powdered sugar, and polysorbate. The preparation method includes: preparing materials, extracting effective ingredients of herbal materials, and performing granulating and tableting. The miconazole nitrate compound vaginal extended-release effervescent tablets are a Chinese and western medicine mixture, the defect that miconazole nitrate is only capable of killing germs and diminishing inflammation is effectively overcome, and the herbs are good in synergistic effect. Hydrophilic gel extended-release material is used as a medicinal auxiliary material, acting time of the tablets and administering interval can be prolonged, and bioavailability of the tablets can be improved; the tablets directly act on an affected part, take effect fast, are good in effect, are convenient to use and allow higher patient compliance.

Description

technical field [0001] The invention belongs to the field of topical medication, and specifically relates to a compound miconazole nitrate vaginal slow-release effervescent tablet and a preparation method thereof. Background technique [0002] Vaginitis is the most common infectious disease in women. Its common symptoms are increased vaginal discharge, genital itching and burning pain, which may be accompanied by frequent urination, dysuria and dyspareunia. Gynecological examination showed increased vaginal discharge, vaginal mucosa hyperemia or scattered bleeding spots, a large amount of leucorrhea in the posterior fornix of the vagina, gray-yellow or yellow-green purulent discharge, sometimes foamy or white thick curd or bean dregs. Edema, scratches, and geographic erythema were seen on the vulva. [0003] Vaginal mucosal administration has a history of nearly a hundred years, and it has many advantages compared with traditional oral administration. It can be used not onl...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/46A61P15/02A61P31/10A61K31/4174
Inventor 袁国防周丽萍王小雅孙彦龙
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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