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Compound norfloxacin vaginal effervescent tablet and preparation method thereof

A technology of norfloxacin and effervescent tablets, which is applied in the field of norfloxacin compound vaginal effervescent tablets and its preparation, can solve problems such as abdominal discomfort, dizziness, headache, drowsiness or insomnia, and achieves the promotion of absorption and acceleration of local microbes. Circulation, the effect of increasing the contact surface

Inactive Publication Date: 2015-05-13
王芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, taking norfloxacin by mouth can easily cause abdominal discomfort or pain, diarrhea, nausea or vomiting, and may also cause dizziness, headache, drowsiness or insomnia

Method used

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  • Compound norfloxacin vaginal effervescent tablet and preparation method thereof
  • Compound norfloxacin vaginal effervescent tablet and preparation method thereof
  • Compound norfloxacin vaginal effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The content of each component in norfloxacin compound vaginal effervescent tablet is:

[0033]

[0034]

[0035] A preparation method of norfloxacin compound vaginal effervescent tablet:

[0036] ① Prepare materials according to the content of each component mentioned above;

[0037] ② Glycyrrhizae, Diding, Dandelion, Sophora flavescens, and catechu are superfinely pulverized respectively, and added to a constant temperature extraction tank; adding alcohol with a mass concentration of 95% to the constant temperature extraction tank, the alcohol weight parts are 500 parts, 75-80 Stir at ℃ for 30 minutes, cool to room temperature, and take the supernatant; extract twice in this way, combine the supernatant, and filter through 16 layers of gauze to obtain the filtrate; Concentrate to 8% of the volume of the original filtrate at 50°C to obtain a traditional Chinese medicine extract, which is cooled to room temperature for later use;

[0038] ③The traditional Chinese...

Embodiment 2

[0043] The content of each component in norfloxacin compound vaginal effervescent tablet is:

[0044]

[0045]

[0046] A preparation method of norfloxacin compound vaginal effervescent tablet:

[0047] ① Prepare materials according to the content of each component mentioned above;

[0048] ② Glycyrrhizae, Diding, Dandelion, Sophora flavescens, and catechu are superfinely pulverized respectively, and added to a constant temperature extraction tank; adding alcohol with a mass concentration of 95% to the constant temperature extraction tank, the alcohol weight parts are 500 parts, 75-80 Stir at ℃ for 30 minutes, cool to room temperature, and take the supernatant; extract twice in this way, combine the supernatant, and filter through 16 layers of gauze to obtain the filtrate; Concentrate to 5% of the volume of the original filtrate at 50°C to obtain a traditional Chinese medicine extract, which is cooled to room temperature for later use;

[0049] ③The traditional Chinese...

Embodiment 3

[0054] The content of each component in norfloxacin compound vaginal effervescent tablet is:

[0055]

[0056] A preparation method of norfloxacin compound vaginal effervescent tablet:

[0057] ① Prepare materials according to the content of each component mentioned above;

[0058] ② Glycyrrhizae, Diding, Dandelion, Sophora flavescens, and catechu are superfinely pulverized respectively, and added to a constant temperature extraction tank; adding alcohol with a mass concentration of 95% to the constant temperature extraction tank, the alcohol weight parts are 500 parts, 75-80 Stir at ℃ for 30 minutes, cool to room temperature, and take the supernatant; extract twice in this way, combine the supernatant, and filter through 16 layers of gauze to obtain the filtrate; Concentrate to 6% of the volume of the original filtrate at 50°C to obtain a traditional Chinese medicine extract, which is cooled to room temperature for later use;

[0059] ③The traditional Chinese medicine ex...

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Abstract

The invention discloses a compound norfloxacin vaginal effervescent tablet and a preparation method thereof. The compound norfloxacin vaginal effervescent tablet consists of a Western medicine, a Chinese medicine and a medicinal auxiliary material, wherein the Western medicine comprises the following active components in parts by weight: 4-6 parts of norfloxacin and 10-20 parts of borneol; the Chinese medicine comprises the following raw herbs in parts by weight: 70-80 parts of liquorice, 145-155 parts of viola mandshurica, 125-135 parts of dandelion, 115-125 parts of sophorae flavescentis and 80-90 parts of catechu; the parts of the medicinal auxiliary material by weight is 30-40. The compound vaginal effervescent norfloxacin tablet is a combination of Chinese and Western medicines, is used for topical treatment, is convenient to use, and can increase a contact surface of a medicine and a human body after effervescing so as to improve the medicinal efficacy; through a traditional therapeutic method that the Chinese medicine treats root causes and the Western medicine treats symptoms, the compound norfloxacin vaginal effervescent tablet can treat urinary tract infection, leukorrhagia and yellow leucorrhea caused by sensitive bacteria and other gynaecological diseases.

Description

technical field [0001] The invention relates to a vaginal effervescent tablet, in particular to a norfloxacin compound vaginal effervescent tablet and a preparation method thereof. Background technique [0002] Norfloxacin is a third-generation quinolone antibacterial drug, which can hinder the action of DNA Gyrase (DNA Gyrase) of pathogenic bacteria, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. It has broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli, and is suitable for urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections caused by sensitive bacteria. However, oral norfloxacin can easily cause abdominal discomfort or pain, diarrhea, nausea or vomiting, and may also cause dizziness, headache, drowsiness or insomnia. Contents of the invention [0003] In order to overcome the adverse reaction of oral norfloxacin an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K9/46A61P15/02A61K31/045A61K31/496
Inventor 王芬
Owner 王芬
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