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Preparation method of metronidazole clotrimazole and chlorhexidine acetate vaginal effervescent tablet

A technology of Shuangzotai and effervescent tablets, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problem of reducing foaming volume, affecting drug quality and clinical efficacy, etc. question

Active Publication Date: 2012-03-21
南京海鲸药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all successfully prepare effervescent tablets, but effervescent tablets, especially vaginal effervescent tablets, will absorb moisture in the air during storage and reduce the amount of foaming, thereby affecting drug quality and clinical efficacy.

Method used

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  • Preparation method of metronidazole clotrimazole and chlorhexidine acetate vaginal effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Place the Shuangzotai vaginal effervescent tablet core in a coating pan, coat with an absolute ethanol solution containing 2.5% ethyl cellulose and 0.25% polyethylene glycol 800, wrap an isolation layer, and increase the weight by 0.22%. Then with 85% ethanol solution containing 2.5% hypromellose (5CP) and 0.25% triacetin. 2.8% weight gain.

Embodiment 2

[0031] Put the Shuangzotai vaginal effervescent tablet core into the coating pan, coat with an absolute ethanol solution containing 3.5% ethyl cellulose and 0.2% polyethylene glycol 2000, wrap an isolation layer, and increase the weight by 0.38%. Then with 75% ethanol solution containing 5.0% hypromellose (5CP) and 0.25% triethyl citrate. 4.0% weight gain.

Embodiment 3

[0033] Place the Shuangzotai vaginal effervescent tablet core in a coating pan, coat with an absolute ethanol solution of 2.5% ethylcellulose and 0.3% polyethylene glycol 2000, wrap an isolation layer, increase the weight by 0.60%, and then Take 2.5% Opadry in ethanol solution. 2.5% weight gain.

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PUM

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Abstract

The invention relates to a metronidazole clotrimazole and chlorhexidine acetate vaginal effervescent tablet, which consists of a tablet core, an isolating layer and a filmcoating layer, wherein the tablet core of the metronidazole clotrimazole and chlorhexidine acetate vaginal effervescent tablet is firstly prepared, and then ethyl cellulose and polyethylene glycol are wrapped by the isolating layer and are finally wrapped by filmcoating. The appearance, foaming amount and other indicators of the vaginal effervescent tablet are stable during the storage process, and the storage requirement islow, so the use and curative effect of the medicine are ensured.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and mainly relates to a Shuangzotai vaginal effervescent tablet, which is composed of a tablet core, an isolation layer and a film coating layer. The effervescent tablet adopts double-layer coating technology to improve the stability of the drug , guaranteed curative effect. Background technique [0002] Shuangzotai vaginal effervescent tablet is a compound preparation, its main active ingredients are metronidazole, clotrimazole, and chlorhexidine acetate, containing 200mg of metronidazole, 160mg of clotrimazole, and 8mg of chlorhexidine acetate. [0003] Metronidazole in Shuangzotai vaginal effervescent tablets has the effect of inhibiting and killing anaerobic bacteria, trichomonas and amoeba, clotrimazole has the effect of inhibiting and killing fungi, and chlorhexidine acetate has the effect of inhibiting and killing aerobic bacteria. It is clinically used for the treatment of bact...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61K31/4164A61K31/155A61K9/46A61K47/38A61P15/02A61P31/04A61P31/10A61P33/02
Inventor 时文祥叶靖谢晓燕相文杰
Owner 南京海鲸药业股份有限公司
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