Formula for erosion removal vaginal effervescent tablets and process for preparing same
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An effervescent tablet and vaginal technology, applied in the field of gynecological medicine, can solve the problems of active ingredient destruction and inconvenient use
Inactive Publication Date: 2016-06-15
李达
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The preparation research of comfrey, in addition to the traditional water decoction, oil, ointment, injection, cream, film and other forms are also emerging, according to literature reports, comfrey is extracted with vegetable oil to make comfrey oil, which is beneficial to the treatment of Cervical erosion and vaginitis have a good curative effect, but the high temperature used in the preparation method can destroy the active ingredients, and it is inconvenient to use
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Embodiment 1
[0019] A formula of Xiaomi vaginal effervescent tablet is made according to the following parts by weight:
[0022] Wherein, the extraction method of the comfrey extract is as follows: take 5.0 g of the dried root of comfrey, chop it into small pieces, place it in a 500 mL round-bottomed flask, add 100 mL of petroleum ether, reflux in a water bath at different temperatures, and use Filtrate through gauze, distill the filtrate under reduced pressure, concentrate to 10 mL, transfer the concentrated solution to a watch glass, let it dry naturally, and obtain a dark red paste, determine the content of levoshikonin.
[0023] Wherein, the extraction method of the comfrey extract is as follows: take 10 g of comfrey, crush it, soak it with 95% ethanol at room temperature, use 100 mL of alcohol each time, replace th...
Embodiment 2
[0028] A formula of Xiaomi vaginal effervescent tablet is made according to the following parts by weight:
[0031] Wherein, the extraction method of the comfrey extract is as follows: take 5.0 g of the dried root of comfrey, chop it into small pieces, place it in a 500 mL round-bottomed flask, add 100 mL of petroleum ether, reflux in a water bath at different temperatures, and use Filtrate through gauze, distill the filtrate under reduced pressure, concentrate to 10 mL, transfer the concentrated solution to a watch glass, let it dry naturally, and obtain a dark red paste, determine the content of levoshikonin.
[0032] Wherein, the extraction method of the comfrey extract is as follows: take 10 g of comfrey, crush it, soak it with 95% ethanol at room temperature, use 100 mL of alcohol each time, replace ...
Embodiment 3
[0037] A formula of Xiaomi vaginal effervescent tablet is made according to the following parts by weight:
[0040] Wherein, the extraction method of the comfrey extract is as follows: take 5.0 g of the dried root of comfrey, chop it into small pieces, place it in a 500 mL round-bottomed flask, add 100 mL of petroleum ether, reflux in a water bath at different temperatures, and use Filtrate through gauze, distill the filtrate under reduced pressure, concentrate to 10 mL, transfer the concentrated solution to a watch glass, let it dry naturally, and obtain a dark red paste, determine the content of levoshikonin.
[0041] Wherein, the extraction method of the comfrey extract is as follows: take 10 g of comfrey, crush it, soak it with 95% ethanol at room temperature, use 100 mL of alcohol each time, replace the...
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Abstract
The invention relates to the technical field of gynecological medical treatment, in particular to a formula for erosion removal vaginal effervescent tablets.The erosion removal vaginal effervescent tablets comprise, by weight, 2.5-3 parts of radix arnebiae seu lithospermi extract, 10-12 parts of citric acid, 8-10 parts of sodium bicarbonate, 20-24 parts of lactose and 2-3 parts of lubricants.A process for preparing the erosion removal virginal effervescent tablets includes preparation steps of dividing the lactose into two portions; uniformly mixing one portion of the lactose with the radix arnebiae seu lithospermi extract and the citric acid to obtain a first mixture; uniformly mixing the other portion of the lactose with the sodium bicarbonate to obtain a second mixture; respectively granulating the first mixture and the second mixture by the aid of 5% PVP (polyvinyl pyrrolidone) absolute ethyl alcohol solution to obtain granules; drying the granules at the temperature of 50 DEG C and uniformly mixing the granules with PEG-6000 (polyethylene glycol-6000) to obtain third mixtures; tabletting and shaping the third mixtures to obtain the erosion removal virginal effervescent tablets.The 5% PVP absolute ethyl alcohol solution is used as adhesive.The formula and the process have the advantages that the virginal effervescent tablets are prepared after effective components in radix arnebiae seu lithospermi are extracted, so that patients can conveniently utilize the vaginal effervescent tablets, each erosion removal vaginal effervescent tablet in a prescription contains an acid source and a carbon dioxide source, each acid source and the corresponding carbon dioxide source can quickly react to each other to generate carbon dioxide gas when in contact with water, accordingly, the tablets can be disintegrated within a short time, principle medicines can be released, medicines can be uniformly released along with foam, and contact between the medicines and the vaginal mucous membranes of the patients can be improved.
Description
technical field [0001] The invention relates to the technical field of gynecological medicine, in particular to a formula and a preparation process of Xiaomi vaginal effervescent tablet. Background technique [0002] Xiaomi vaginal effervescent tablet is an improved dosage form of "Chinese Pharmacopoeia" 2X (Qiao Nian edition) a variety of Xiaomi suppository, with Phellodendron Phellodendron, Sophora flavescens, Comfrey extract, Ginseng soap II, catechu, dried alum, borneol and auxiliary materials The drug in the vaginal effervescent tablet can be evenly distributed in the epithelial cells of the vaginal mucosa with the foam, and penetrate into the deep part of the mucosal folds, which increases the contact surface between the drug and the vaginal wall and cervix, fully exerts the therapeutic effect of the drug, and overcomes the Generally, tablets dissolve slowly, and the distribution surface is narrow and uneven; after the suppository matrix melts, the medicine will be los...
Claims
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Application Information
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