Action of ferulic acid on enhancing drug effect of some medicaments and purpose thereof

A kind of technology of ferulic acid and medicine, applied in the field of pharmacological action

Inactive Publication Date: 2010-06-09
QINGDAO QIYUAN BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This new discovery has not been reported at home and abroad

Method used

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  • Action of ferulic acid on enhancing drug effect of some medicaments and purpose thereof
  • Action of ferulic acid on enhancing drug effect of some medicaments and purpose thereof
  • Action of ferulic acid on enhancing drug effect of some medicaments and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, the observation that ferulic acid increases the water solubility of alkaloid drugs

[0020] The ferulic acid and the alkaloid drugs are respectively mixed in a molar ratio of 1:1; 1:2; 1:3; 1:4; 1:5; 1:6, and then ground in a ball mill. After 15 minutes, the drug was taken out, and the change of water solubility was observed.

[0021] The results are shown in Table 1.

[0022] Table 1. Observation of Ferulic Acid on the Solubility of Alkaloids in Aqueous Solution (mg / mL)

[0023]

Embodiment 2

[0024] Embodiment two, the observation that ferulic acid increases flavonoids water-solubility and fat-solubility

[0025] Ferulic acid and flavonoid base drugs are respectively used in a molar ratio of 1:1; 1:2; 1:3; 1:4; 1:5; 1:6 according to the method of chemical synthesis to synthesize salts, ketones, After separation and purification of esters, ethers, and amides, observe the changes in water solubility and fat solubility.

[0026] The results are shown in Tables 2 and 3.

[0027] Table 2. Observation of the solubility of ferulic acid to flavonoids in aqueous solution (mg / mL)

[0028]

[0029] Table 3. Observation of Ferulic Acid on the Solubility of Flavonoids in Lipids (mg / mL)

[0030]

Embodiment 3

[0031] Embodiment three, the observation of the dissolubility and antitumor activity of paclitaxelone ferulate

[0032] Paclitaxel has good anticancer activity and has become the third generation of anticancer drugs. Paclitaxel has good effects in the treatment of ovarian cancer and breast cancer, and has a good prospect in the treatment of prostate cancer, upper gastrointestinal cancer, small cell and non-small cell lung cancer. Since paclitaxel is almost insoluble in water, a cosolvent needs to be added during use. However, its cosolvent can cause severe allergy to patients and even individual death, which restricts its application. The ester compound produced by the esterification reaction between ferulic acid and paclitaxel can greatly increase the water solubility of paclitaxel and have obvious synergistic effect on its antitumor activity.

[0033] Materials and Methods:

[0034] Gastric cancer BGC2823 cells were purchased from Shanghai Institute of Cell Biology, Chine...

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PUM

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Abstract

The invention relates to an action of ferulic acid on enhancing the drug effect of some medicaments and a purpose thereof, wherein the medicaments mainly comprise alkaloid medicaments including matrine, kushenin, sophocarpine, hyoscyamine, narceine, hanfangchin A, jamaicin, morphine, codeine, evodiamine, strychnine, catharanthine, vincristine, taxol, verticine, peimine, peiminine, ephedrine, pseudoephedrine, wilfordine, triptolide, tripdiolide and the like, and flavonoid medicaments including puerarin, ginsenoside, ginsengenin, mangiferin, scutelloside, alkannin, meletin, rutin, hesperidin, daidzin, soybean isoflavone, daidzein, carthamin, catechin and the like. The ferulic acid and the medicaments can form a compound or a medicament compound, or the ferulic acid and the medicaments can generate a chemical reaction (including salification, esterification, amidation, ketonization, etherification and the like), and/or the ferulic acid and the medicaments can generate a synergistic effect and an additive effect.

Description

[0001] Technical field: the present invention relates to ferulic acid in increasing the efficacy of certain medicines and its use. Background technique [0002] Ferulic acid, chemically named 4-hydroxy-3-methoxyphenylacrylic acid, is a phenolic acid from a variety of plants. It combines with polysaccharides and proteins in the cell wall to become the skeleton of the cell wall. Studies have shown that ferulic acid is one of the active ingredients of many traditional Chinese medicines such as Ferulicum, Chuanxiong, Angelica, Cimicifuga, Equisetum, etc. [0003] Ferulic acid is phenylacrylic acid, molecular formula C 10 h 10 o 4 , Molecular weight 194.18, the structural formula is as follows, there are two products of cis and trans, the cis is a yellow oily substance, and the trans is a sloping needle crystal (water), which has strong oxidation resistance and reduction. [0004] [0005] Since the alkanes in the ferulic acid molecule are short and contain double bonds, they...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K45/00A61K47/12A61K47/14
Inventor 马维富彭康康宋健
Owner QINGDAO QIYUAN BIO TECH CO LTD
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