Prepn of matrine, oxymatrine and sophoxidine from flavescent sophora root

A technology of oxymatrine and production process, applied in the field of matrine, can solve the problems of complicated procedures, high cost, difficult industrialized scale production and the like

Inactive Publication Date: 2003-11-05
王答祺 +2
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Problems solved by technology

[0003] At present, most extract matrine, oxymatrine or sophoridine from Sophora flavescens, and there are few literature reports on extracting matrine, oxymatrine or sophoridine from Sophora flavescens, and all of them are extracted from Sophora flavescens Only one alkaloid can be extracted at a time. For example, CN1073681A, published on June 30, 1993, reports a method for extracting matrine from Sophora flavescens by freezing vacuum method. The literature reports of matrine and sophoridine have not been found so far, and the traditional preparation process has complicated procedures and high cost, it is difficult to form industrial scale production, and the purity of more than 98% cannot be achieved, which greatly hinders matrine, Application of oxymatrine and sophoridine in pharmacy and clinic

Method used

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  • Prepn of matrine, oxymatrine and sophoxidine from flavescent sophora root
  • Prepn of matrine, oxymatrine and sophoxidine from flavescent sophora root

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Embodiment

[0014]Select high-quality Sophora flavescens produced in Northwest China, dry it, crush it to 40 meshes, and obtain 200 kg of Sophora flavescens powder, moisten it with 100L of 0.5% H2SO4 solution, leave it for more than 2 hours, put it into a 2000L stainless steel multifunctional extraction tank, and add 800L for the first time Water, heated to 75±5°C, kept at this temperature, forced to circulate water for 2 hours, and filtered out the solution; add 600L water to the multi-functional extraction tank for the second time, heated to 75±5°C, maintained at this temperature, forced to circulate for 2 hours, filtered out of the solution; add 500L of water to the multifunctional extraction tank for the third time, heat at 75±5°C, keep the temperature, force the water to circulate for 2 hours, and filter out the solution; combine the three extracts, filter out the clear liquid, and use double-effect evaporation Concentrate at 80°C and under vacuum conditions below -0.08MPa, evaporate ...

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Abstract

The production process features that dried and crushed flavescent sophora root is processed through extraction, concentration, alkalization, reduction, solvent extraction, acid reverse extraction, deposition and separation to produce coarse matrine product and coarse sophoridine product; coarse matrine product and coarse sophoridine product are recrystallized and dried to obtain matrine product and sophoridine product; and matrine is further processed through oxidation with hydrogen peroxide, decompression distillation, crystallization, filtering, re-crystallization and drying to obtain oxymatrine product. The said three products are material for producing medicine for treating hepatitis B, hepatitis C, leucopenia, arrhythmia, cancer and other diseases.The production process of the present invention is simple, low in cost, high in product purity and suitable for industrial production.

Description

technical field [0001] The invention relates to a production process for preparing matrine, oxymatrine and sophoridine which can be used as medical raw materials from Sophora flavescens. Background technique [0002] Sophora flavscens Alt. is a commonly used Chinese herbal medicine, which has been described in many herbal works in the past dynasties. It is the dried root of Sophora flavscens Alt., which has the functions of clearing away heat, dehumidification, killing insects, and diuresis; it is widely distributed in my country. Rich in resources, the alkaloids contained in Sophora flavescens are considered to be the main biologically active components. Seventeen kinds of alkaloids have been isolated and identified from Sophora flavescens, mainly: Sophocarpine, Matrine (matrine), sophoridine (sophoridine), oxymatrine (oxymatrine), oxysophcarpine (oxysophcarpine), these five alkaloids account for more than 90% of the total alkaloids, pharmacological experiments and clinical a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/00
CPCY02P20/582
Inventor 王答祺李静王新莉
Owner 王答祺
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