Alkaloids sophora flavescen pellicle and its preparation process

A technology of matrine total alkaloids and matrine, applied in sheet delivery, sexual diseases, drug combination and other directions, can solve problems such as the advent of film products, and achieve the effects of safe use, easy portability and fast absorption

Inactive Publication Date: 2005-03-16
贵阳高新瑞得科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gynecological film varieties are pharmaceutical dosage forms that have been rapidly developed in research and application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Weigh 50g of polyvinyl alcohol, add 200ml of water, soak for 0 hours, put it in a water bath at 20°C to dissolve it, take 50mg of total alkaloids of matrine and mix with the aqueous solution, remove air bubbles, and apply it to form a film. After drying for 0.5 hour, 1000 film products were obtained.

Embodiment 2

[0024] Embodiment 2: Take sodium carboxymethyl cellulose 150g, add water 400ml, soak for 0.5 hours, place it in a 50°C water bath and dissolve it, take 100mg of Sophora flavescens and dissolve it with a mixed solution of 50ml of water and ethanol, and then dissolve the two Mix the two solutions and stir evenly, add 0.2 g of sodium sulfite, mix well, remove air bubbles, apply and form a film, and dry for 1 hour to obtain 1000 film products.

Embodiment 3

[0025] Example 3: Weigh 300g of starch, add 500ml of water, soak for 3 hours, place it in a water bath at 60°C to dissolve it, take 250mg of matrine total alkaloids and dissolve them with a mixed solution of 300ml of water and ethanol, then mix and stir the two solutions Evenly, add 1.5g of sodium bisulfite, mix evenly, remove air bubbles, apply and form a film, and dry for 1.5 hours to obtain 1000 film products.

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PUM

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Abstract

Disclosed is a alkaloids sophora flavescen pellicle and its preparation process, wherein the pellicle comprises matrine and oxymatrine as the active constituents, and added anti-oxidant and fill forming material. The preparation process includes, steeping the film forming material with water, dissolving by water-bath, dissolving the matrine and total matrines with the mixed solution of water and ethanol, mixing with the aqueous solution of the film forming material, adding anti-oxidant simultaneously, mixing, removing air bubbles, coating into film and drying.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a film agent of total alkaloids of matrine for treating women's vaginitis and a preparation method thereof. Background technique [0002] Non-specific vaginitis is a common and frequently-occurring disease in women, usually caused by vaginal mold, trichomonas, and bacterial infections, often presenting symptoms such as profuse leukorrhea, yellowish smell, itchy vulva, bitter mouth, and chest tightness. Bring great pain and inconvenience to patient. For vaginitis, both Chinese and Western medicine have some treatment methods, and Chinese medicine also has proven prescriptions for treatment. Among them, there are already "Baofukang Suppositories" and "Fuyankang Suppositories" on the market. Sometimes there is a foreign body feeling, the volume is large, and the use is greatly affected by environmental conditions, especially temperature and humidity. [0003...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4375A61P15/02
Inventor 李向东卢顺林何斌余昌昀
Owner 贵阳高新瑞得科技开发有限公司
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