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Application of ginkgolic acid in preparation of external preparation for treating dermatopathy

A technology of ginkgo phenolic acid and external preparation is applied in the fields of biomedicine and therapeutic cosmetics, and can solve the problems such as unseen use of ginkgo phenolic acid, deterioration of skin lesions, side effects, etc., and achieves the promotion of wound healing, wide effect, safe use and no side effects. Effect

Active Publication Date: 2012-01-18
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most infectious skin diseases are treated with antibacterial drugs, antiviral drugs or antifungal drugs, and most of the drugs used for the treatment of inflammatory and allergic skin diseases are corticosteroids and antihistamines. Skin lesions often worsen after stopping the drug, which is the so-called "rebound phenomenon"; and long-term use will cause many side effects
There is no report on the use of ginkgolic acid in the preparation of external preparations for the treatment of inflammatory and allergic skin diseases

Method used

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  • Application of ginkgolic acid in preparation of external preparation for treating dermatopathy
  • Application of ginkgolic acid in preparation of external preparation for treating dermatopathy
  • Application of ginkgolic acid in preparation of external preparation for treating dermatopathy

Examples

Experimental program
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Effect test

Embodiment 1

[0077] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).

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Embodiment 2

[0083] The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0084] G...

Embodiment 3

[0088] The extraction process of ginkgolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0089] Ginkgolic a...

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Abstract

The invention relates to an application of ginkgolic acid in preparation of an external preparation for treating dermatopathy. The ginkgolic acid comprises ginkgoic acid, ginkgol, ginkgo diphenol, and the like, and can be obtained from extracts of leaves, fruit, exopleura, and rhizome of ginkgo by a chemical separation method. The dermatopathy is infectious, inflammatory, allergic or anaphylactic dermatopathy. External preparations of ginkgolic acid-containing medicaments, cosmetics, or disinfectants for treating dermatopathy comprises 0.001-80% (by weight) of ginkgolic acid, and pharmaceutically common external preparation substrates or acceptable carriers; the preparation has any pharmaceutical dosage form. Pharmacological experimental research shows that the preparation of the invention has significant effect of anti-infection of skin resident pathogens, anti-inflammation, antianaphylaxis, anti-allergy, analgesia, itching relief, and wound heal promotion. Clinical trials show that the preparation of the invention has significant treatment effect on various dermatopathy, has an effective rate of up to 100%, is safe and has no side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and therapeutic cosmetics, and specifically relates to the use of ginkgolic acid in the preparation of external preparations for treating skin diseases. Background technique [0002] Skin disease is one of the most common clinical diseases. With the improvement of people's living standards, various skin diseases have an increasing trend year by year in various places. Because most skin diseases have a long duration and are prone to repeated attacks, they bring suffering to patients and seriously affect their physical and mental health. Common skin diseases include inflammatory and allergic skin diseases. Inflammatory skin diseases (dermatitis) can be divided into infectious and non-infectious. Infectious skin diseases can be caused by bacteria, viruses, fungi and pathogens, such as impetigo, folliculitis, acne, herpes, tinea manuum, tinea corporis, Acariasis, scabies, etc.; allergic or aller...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P17/00A61P17/06A61P29/00A61P37/08A61P31/00A61P31/10A61P33/14A61K125/00A61K127/00A61K131/00
Inventor 王青雷红
Owner 王青
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