Process for extracting oxymatrine and matrine from sophora moocroftiana

A technology of oxymatrine and matrine, applied in the direction of organic chemistry, etc., can solve the problems of poor solubility, inappropriateness, and no industrial applicability

Inactive Publication Date: 2007-06-13
INST OF GEOGRAPHICAL SCI & NATURAL RESOURCE RES CAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Chinese patent VN1473830A (February 11, 2004) discloses "A Process for Extracting Matrine and Sophoridine from White Thorn Flower or Sophora japonica", which uses toluene extraction method to extract matrine under acidic conditions On the one hand, due to the poor solubility of matrine in toluene under acidic conditions, on the other hand, under the environmental conditions of the Qinghai-Tibet Plateau, it is not suitable to use a large amount of toluene solvents, so this process has no industrial applicability

Method used

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  • Process for extracting oxymatrine and matrine from sophora moocroftiana

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) 10 kg of Sophora japonica seeds (4.43% oxymatrine content, 0.19% matrine content), crushed into a size of about 1mm, add 3 kg of water, stir evenly, put in a large bucket, seal and place for 24 hours, The seeds are crushed and swell by more than 2 / 3 of water;

[0025] (2) move the imbibition locust tree into the ethanol thermal reflux device, add 87% industrial ethanol, make the ethanol can immerse the material, and place it for 12 hours; the ethanol liquid is put into the concentration tank, and then add 87% ethanol, Carry out heating and reflux extraction, and use bismuth potassium iodide reagent until the extract does not show alkaloid reaction, and it takes about 8 hours. Concentrate and reclaim ethanol under reduced pressure until most of the ethanol is evaporated. At this time, the concentrated solution is about 3.2 liters, and the reclaimed ethanol can be reused;

[0026] (3) The concentrated solution is acidified with a 1:4 sulfuric acid solution to make th...

Embodiment 2

[0034] 1. 10 kg of dry branches of Sophora japonica (containing 1.69% oxymatrine and 0.30% matrine) were crushed to less than 1mm, added 4 kg of water, mixed well, sealed and placed for 24 hours;

[0035] 2. Put the branch material into the ether heat reflux extractor, add 90% industrial ethanol, make the ethanol immerse the material, seal and soak for 10 hours, put the ethanol into the concentration tank, and then add 90% ethanol for heating and reflux extraction until extraction The extraction process is about 7 hours until the liquid does not show alkaloid reaction;

[0036] Recover ethanol under reduced pressure, so that there is no ethanol in the extract and continue for a while until the volume is about 3L;

[0037] 3. The concentrated solution was acidified with 1:2 hydrochloric acid solution to make the pH to 3-4, and the insoluble solid was dissolved by centrifugal filtration to obtain a light brown clear liquid;

[0038] 4. The acidified solution was eluted 5 times ...

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Abstract

This invention relates to a technology that extracts ammothamnine and matrine from Tibet sandliving sophora seed. Seeds or branch of sandliving sophora seed are shattered. Through ethanol water bath reflux extracting, concentration, acidification, filtration, defatting, alkalization, organic solvent extraction, reclaiming solvent, total alkali of sandliving sophora seed is obtained; Total alkali is dissolved by using acetone, precipitated by using diethyl ether.

Description

Technical field: [0001] The invention relates to a process for extracting oxymatrine and matrine from Sophora japonica. Background technique: [0002] Sophora moorcroftiana (Sophora moorcroftiana) is a unique plant on the Qinghai-Tibet Plateau. It is a perennial shrub of the genus Sophora in the Fabaceae family. Sand-grown locust tree is drought-resistant, cold-resistant, wind-resistant, sand-resistant, and widely adaptable. It has a strong wind-proof and sand-fixing effect. It plays an extremely important role in the evolution of the ecological environment in the Tibetan plateau valley area, and has become one of the important tree species for plateau greening. . The whole plant of Sophora japonica contains Sophora flavescens alkaloids, especially the content of oxymatrine in the seeds is as high as more than 4%. Sophora alkaloids have anti-bacterial, anti-inflammatory, anti-viral, anti-arrhythmic, heat-clearing and detoxifying, expelling wind and insecticidal effects, es...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/00
Inventor 管正学张宏志王旭王建立
Owner INST OF GEOGRAPHICAL SCI & NATURAL RESOURCE RES CAS
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