The invention discloses a pesticide composition containing sedaxane. Effective active ingredients of the composition consist of sedaxane, tebuconazole and an effective ingredient C, wherein the effective ingredient C is thiamethoxam or imidacloprid, the weight ratio of sedaxane to tebuconazole to the effective ingredient C is (1-80): (1-80): (1-80), and the composition is made into a suspended seed coating. The composition disclosed by the invention can be used for preventing and treating a variety of underground pests and harmful bacteria and has an obvious synergistic effect, the control spectrum is enlarged, and the composition has relatively high activity to pests and harmful bacteria on wheat, vegetables, cotton, peanuts, watermelon and rice; the pests consist of aphids, midge, root-knot nematodes, wireworms, grubs, cutworms, thrips, mole crickets, athetis lepigone and borers, and diseases consist of sheath blight, bakanae disease, gummy stem blight, rust disease, stripe rust, root rot, head blight, powdery mildew, anthracnose, head smut and full rot. The composition has a sustained-release effect, the dosage of pesticides is reduced, and the composition is safe to human and livestock, is free from damage caused by chemicals and is good in environmental compatibility.