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Effective parts of schisandra bee pollen and application thereof in liver injury prevention

A technology of schisandra bee pollen and effective parts, applied in the direction of medical preparations containing active ingredients, applications, organic active ingredients, etc., can solve the problem of large dosage

Inactive Publication Date: 2013-07-03
NORTHWEST UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently taking bee pollen directly has the disadvantage of taking a large amount

Method used

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  • Effective parts of schisandra bee pollen and application thereof in liver injury prevention
  • Effective parts of schisandra bee pollen and application thereof in liver injury prevention
  • Effective parts of schisandra bee pollen and application thereof in liver injury prevention

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Preparation of effective parts of Schisandra bee pollen

[0022] Take 1000g of broken-wall Schisandra bee pollen, add 8000ml of 95% ethanol, and extract under reflux at 60°C for 8 hours, extracting twice in total, combining the two extracts, filtering, and concentrating the filtrate under reduced pressure at a concentration temperature of 40°C until alcohol-free Taste, and a certain volume, transfer with water, heat to dissolve. Adsorb the solubilized matter with AB-8 resin, elute with 50% ethanol by volume ratio, recover ethanol from the eluate under reduced pressure until it tastes alcohol, and have a certain volume, transfer it with water, heat to dissolve, and then adsorb it with XAD-2 type resin , Concentrated to dryness with 50% ethanol eluate by volume, which is the effective part of the present invention.

[0023] The composition and content of active ingredients are: gallic acid 15.78±1.64 mg / kg, protocatechuic acid 54.78±5.09 mg / kg, vanillic acid...

Embodiment 2

[0024] Example 2: Preparation of effective parts of Schisandra bee pollen

[0025] Take 1000g of broken-wall Schisandra bee pollen, add 10000ml of 75% ethanol, and extract under reflux at 70°C for 6 hours, extract twice in total, combine the two extracts, filter, and concentrate the filtrate under reduced pressure at a concentration temperature of 40°C until it is alcohol-free Taste, and a certain volume, transfer with water, heat to dissolve. Adsorb the solubilized matter with AB-8 resin, elute with 70% ethanol by volume ratio, recover ethanol from the eluate under reduced pressure until it tastes alcohol, and have a certain volume, transfer it with water, heat to dissolve, and then adsorb it with XAD-2 type resin , concentrated to dryness with 60% ethanol by volume, which is the effective part of the present invention.

[0026] The composition and content of active ingredients are: gallic acid 15.78±1.64 mg / kg, protocatechuic acid 54.78±5.09 mg / kg, vanillic acid 64.21±5.1...

Embodiment 3

[0027] Example 3: Preparation of effective parts of Schisandra bee pollen

[0028] Take 1000g of broken-wall Schisandra bee pollen, add 12000ml of 55% ethanol, reflux at 50°C for 12 hours, extract twice in total, combine the two extracts, filter, and concentrate the filtrate under reduced pressure at a concentration temperature of 40°C until alcohol-free Taste, and a certain volume, transfer with water, heat to dissolve. Adsorb the solubilized matter with AB-8 resin, elute with 80% ethanol by volume ratio, recover ethanol from the eluate under reduced pressure until it tastes alcohol, and have a certain volume, transfer it with water, heat to dissolve, and then adsorb it with XAD-2 type resin , concentrated to dryness with 60% ethanol by volume, which is the effective part of the present invention.

[0029] The composition and content of active ingredients are: gallic acid 15.78±1.64 mg / kg, protocatechuic acid 54.78±5.09 mg / kg, vanillic acid 64.21±5.13 mg / kg, p - Coumaric ...

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Abstract

The invention relates to effective parts of schisandra bee pollen and the application thereof in liver injury prevention. The effective parts are obtained through extracting the schisandra bee pollen using ethanol, and the active ingredients and the content are gallic acid 15.78+ / -1.64 mg / kg, protocatechuic acid 54.78+ / -5.09 mg / kg, vanillic acid 64.21+ / -5.13 mg / kg, p-coumaric acid 57.32+ / -5.25 mg / kg, quercetin 273.63+ / -20.84 mg / kg, hesperidin 741.56+ / -76.8 mg / kg, kaempferol 387.34+ / -35.65 mg / kg, and galangin 487.35+ / -47.24 mg / kg. The inventor has found that the antioxidant activity of the schisandra bee pollen is higher than that of all known commercial bee pollen, and that the schisandra bee pollen can be used for preparing medicine or health care food for preventing liver injury caused by carbon tetrachloride.

Description

technical field [0001] The invention relates to effective parts of schisandra bee pollen, an extraction method thereof and an application in preventing liver damage caused by carbon tetrachloride, and belongs to the technical field of medicine and functional food. Background technique [0002] The liver is an important material metabolism organ of the human body, and plays an important role in the absorption, transformation, storage, secretion and excretion of carbohydrates, proteins, fats, vitamins and other nutrients. The liver is also an important protective organ of the human body. It has the functions of detoxification and phagocytosis, especially for the metabolism and biotransformation of many foreign chemical drugs. Through metabolism, some toxic foreign compounds are metabolized into non-toxic or less toxic and easy to excrete. substance. However, some drugs may be transformed into more toxic and accumulative substances after being metabolized by the liver, thereby...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61K31/192A61P1/16A23L1/30
Inventor 曹炜程妮雷兴生高慧邓建军
Owner NORTHWEST UNIV
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