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Application of galangin for treating irritable bowel syndrome, and its extraction method

A technology for irritable bowel syndrome and galangin, applied in the field of galangin, can solve the problems of many adverse reactions and single action mechanism, and achieve the effects of inhibiting the hyperprogression of small intestine and simple extraction and separation process

Inactive Publication Date: 2007-07-25
GUANGDONG PHARMA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The internationally recognized effective drugs for the treatment of IBS, spartamine and pinaverium bromide, although they have few side effects and have good short-term efficacy in relieving symptoms, have a single mechanism of action and are only calcium ion channel antagonists. For IBS with very complicated pathogenesis and mechanism Still unable to do what one wants; while others, such as 5-HT receptor and M receptor antagonists, are difficult to be widely used clinically because of their many adverse reactions

Method used

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  • Application of galangin for treating irritable bowel syndrome, and its extraction method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take galangal medicinal material 2000g, pulverize, and pass through a 40-mesh sieve.

[0025] Take galangal powder and add 6 times the amount of 90% ethanol, reflux at 65°C for 0.5 hour, and filter while it is hot. Add 6 times the amount of 90% ethanol to the dregs, reflux at 65°C for 2 hours, and filter while hot. Combine the two ethanol extracts, recover the ethanol under reduced pressure at 60°C until the alcohol content is 45%, leave it at room temperature for two days, centrifuge, and collect the precipitate. The solution was further concentrated under reduced pressure at 60°C to a solution density of 1.2 (70°C), and combined with the previously collected precipitates. Stir well, and place at room temperature until the solution is clearly separated. Centrifuge, collect the precipitate, and dry to obtain a crude flavonoid dry paste; add 7 times the amount of 95% ethanol to the galangal dry paste, stir at 50°C for 30 minutes, filter with a 200-mesh filter cloth whi...

Embodiment 2

[0029] Take galangal medicinal material 2000g, pulverize, and pass through a 60-mesh sieve.

[0030]Take galangal powder and add 8 times the amount of 60% ethanol, reflux at 85°C for 1.5 hours, and filter while it is hot. Add 6 times the amount of 60% ethanol to the dregs, reflux at 85°C for 0.5 hour, and filter while hot. Combine the two ethanol extracts, recover the ethanol under reduced pressure at 80°C until the alcohol content is 25%, leave it at room temperature for two days, centrifuge, and collect the precipitate. The solution was further concentrated under reduced pressure at 80°C to a solution density of 1.0 (70°C), and combined with the previously collected precipitates. Stir well, and place at room temperature until the solution is clearly separated. Centrifuge, collect the precipitate, and dry to obtain a crude flavonoid dry paste; add 4 times the amount of 95% ethanol to the galangal dry paste, stir at 70°C for 15 minutes, filter with a 200-mesh filter cloth wh...

Embodiment 3

[0034] Take galangal medicinal material 4000g, pulverize, and pass through a 50-mesh sieve.

[0035] Take galangal powder and add 10 times the amount of 70% ethanol, reflux at 75°C for 0.5 hour, and filter while it is hot. Add 6 times the amount of 70% ethanol to the dregs, reflux at 75°C for 2 hours, and filter while hot. Combine the two ethanol extracts, recover the ethanol under reduced pressure at 75°C until the alcohol content is 25%-45%, leave it at room temperature for two days, centrifuge, and collect the precipitate. The solution was further concentrated under reduced pressure at 80°C to a solution density of 1.0-1.3 (70°C), and combined with the previously collected precipitates. Stir well, and place at room temperature until the solution is clearly separated. Centrifuge, collect the precipitate, and dry to obtain a crude flavonoid dry paste; add 5 times the amount of 95% ethanol to the galangal dry paste, stir at 55°C for 25 minutes, filter with a 300-mesh filter ...

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Abstract

An application of the galangin in preparing the medicines for treating irritable bowel syndrome (IBS) is disclosed. The preparing process for extracting galangin features use of alcohol extracting-water deposition method to obtain coarse extract and use of macroreticular resin technique and glucosan gel technique to separate and purify it.

Description

technical field [0001] The invention relates to galangin, in particular to the application of galangin in treating irritable bowel syndrome and its extraction method. Background technique [0002] Irritable bowel syndrome (IBS) is a common digestive system disease characterized by abdominal pain or discomfort, accompanied by changes in stool properties and defecation habits. In the West, epidemiological surveys show that 10% to 20% of healthy people have suffered from this disease, and IBS patients account for more than 50% of the number of gastroenterology outpatients. However, it has been reported in the literature that the medical expenses consumed by IBS in the United States are about 800 million U.S. dollars per year. There is no exact data on the prevalence of the disease in my country. A survey organized by Union Hospital in 1997 showed that the prevalence in Beijing was about 7%. Because its pathogenesis has not been clearly elucidated, it is difficult to have idea...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K36/9062A61K9/20A61K9/48A61P1/00A61K125/00
Inventor 冯毅凡石忠峰陈玲陈耕夫黄郁孟青
Owner GUANGDONG PHARMA UNIV
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