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Oral hygiene composition with galangal rhizome extract and its prepn process

A galangal extract, oral hygiene technology, applied in the directions of drug combination, oral care, chewing gum, etc., can solve the problems of too spicy taste, dark color, low content, etc., and achieve significant economic and social significance, light color, source rich effects

Inactive Publication Date: 2007-06-06
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] What needs to be made aware of is that the development of galangal medicinal resources and the application of galanga extract containing galangin and other flavonoid active ingredients to oral health care compositions can benefit human beings and have significant economic and social significance: Galangal is rich in galangin and other flavonoid antibacterial, anti-inflammatory, antiviral and analgesic active ingredients; galangal has been used for the treatment of oral diseases and health care for thousands of years. It does not contain allergens like propolis; galangal is widely planted, rich in sources, and cheaper than propolis; however, the content of flavonoids such as galangin in the galangal extract obtained by conventional extraction methods is low, and the taste is too spicy. The color is also too dark, so it is not accepted by the general public for the preparation of oral hygiene compositions, and technical improvement is needed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of galangal extract

[0025] Grind 1.0 kg of dried rhizome of galangal to 40 mesh, use ethyl acetate as extractant, heat and reflux in water bath for 2 hours; filter the extract, recover ethyl acetate until it has no ester smell, and obtain 81.5 g of brown viscous paste Crude extract A; dissolve it in ethanol to make a water-containing ethanol solution with an ethanol content of 72% (v / v), add an equal volume of petroleum ether (boiling range 60-90°C) to the water-containing ethanol solution, and extract , layering; separate the aqueous ethanol solution layer, add 1% (w / w) activated carbon, heat and reflux for decolorization for 30min, filter, and recover the ethanol from the decolorization filtrate under the conditions of <65°C and -0.095MPa, and concentrate to dryness to obtain yellow Galangal extract B70.5g.

[0026] Flavonoids include galangin, kaempferol, kaempferol, quercetin, and isorhamnetin.

[0027] Determination method of galan...

Embodiment 2

[0047] Embodiment 2: Toothpaste (Wt%) and preparation method

[0048] Formula: glycerin 29, carboxymethyl cellulose (CMC) 0.6, hydroxyethyl cellulose (HEC) 0.5, saccharin 0.35, benzoic acid 0.15, calcium hydrogen phosphate 49-51, sodium lauryl sulfate 2.6, galangal extract 0.45, the water balance, and the sum of the percentages of each component in the composition is equal to 100%.

[0049] Preparation method: according to the formula, dissolve saccharin and benzoic acid in water, disperse galangal extract, CMC, and HEC in glycerin, mix the two evenly, add calcium bicarbonate and sodium lauryl sulfate, mix and knead, Vacuum degassed, canned. The resulting toothpaste was jade white in color and had a light galangal aroma.

Embodiment 3

[0050] Embodiment 3: dental gel formula (Wt%) and preparation method

[0051] Formula: glycerin 8.0, carbomer 5.0, propylene glycol 60, galangal extract 4.0, adjust the pH value with a small amount of diethanolamine, the balance of water, and make the sum of the percentages of each component in the composition equal to 100%.

[0052] Preparation method: According to the recipe, put glycerin in a mortar, add carbomer to grind it thoroughly to make it moist, then add propylene glycol and galangal extract to the above mortar and grind it thoroughly; then add distilled water while stirring to adjust the pH To neutral, make it form a gel, centrifuge to remove air bubbles. The resulting tooth gel is jade-colored and has a light galangal aroma.

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PUM

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Abstract

The present invention is oral hygiene composite with galangal rhizome extract and its preparation process. The galangal rhizome extract contains galangin in 1-25 % and total flavone over 10 %, and has been treated to eliminate its pungency and color. The galangal rhizome extract has enriched the active antiseptic, antiphlogistic, antiviral and analgesic components of galangal rhizome, less pungency oil component and low chroma, and is suitable for use in oral hygiene composite. The oral hygiene composite is safe, reliable, low in cost and acceptable.

Description

technical field [0001] The invention relates to a natural plant extract, especially a galangal extract and a preparation method thereof, and an oral health care composition using the galangal extract as an active ingredient. Background technique [0002] Galangal (Alpinia officinarum Hance), a plant of the genus Zingiberaceae, has a long history of use and medicinal use in my country. It has the effects of warming the middle, dispelling cold, relieving pain, and relieving spasm. It is used to treat cold pain in the abdomen, vomiting, toothache, etc. . [0003] Galangal has been used as a compound traditional Chinese medicine component for the treatment of oral diseases and health care for thousands of years. "Compendium of Materia Medica" has a record of "Using two inches of galangal and one piece of scorpion (roasted), grind together as powder, rub the sore spot, spit out saliva, and rinse mouth with salt soup" to treat wind toothache and swelling (see Li Shizhen. Compendiu...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K36/9062A61Q11/00A23G4/06A61P1/02
Inventor 邓亦峰
Owner GUANGDONG MEDICAL UNIV
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