Substitute material for repairing articular cartilage and preparation method

A technology of articular cartilage and material body, applied in medical science, prosthesis, etc., can solve the problems of easy wear, aging failure, unsatisfactory performance and use effect of silicone rubber, etc.

Inactive Publication Date: 2009-07-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, silicone rubber is not only easy to wear, but also easy to absorb oily substances in body fluids, resulting in short-term aging failure; as an implant material that needs to be used for a long time, the degradation performance of polyurethane needs to be further improved, and the hydrolysis product of curing agent diisocyanate is a potential carcinogen
[0006] Due to the corresponding deficiencies in the currently prepared cartilage substitute materials, the performance and use effect are still unsatisfactory.

Method used

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  • Substitute material for repairing articular cartilage and preparation method
  • Substitute material for repairing articular cartilage and preparation method
  • Substitute material for repairing articular cartilage and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take by weighing 30g polyvinyl alcohol (PVA) and add 170g water / dimethylsulfoxide mixed solvent (H 2 O / DMSO weight ratio 1 / 2), after ultrasonic dispersion for 40 min, fully dissolved in a water bath at 95°C to obtain a 15% PVA solution. Weigh 30g of N-vinylpyrrolidone (NVP) and dissolve it in PVA solution, drop the temperature to 40-50°C and maintain this temperature, pass into nitrogen protection, add 1g of hydrogen peroxide with a mass fraction of 30% as initiator, 1g of mass fraction Ammonia water with a fraction of 25% is used as an activator, the pH of the mixed solution is adjusted to 7-8, and the reaction is stirred at 800 rpm for 1-2 hours until the temperature of the mixed solution rises and then decreases. Then add 1.5g of N,N-methylenebisacrylamide cross-linking agent, stir at 800 rpm for 10 minutes, let it stand for defoaming, freeze at -30°C for 12 hours, and then take it out at room temperature at 20°C Thaw for 4 hours, repeat the operation 7 times, soak ...

Embodiment 2

[0032] Weigh 30g of PVA and add 170g of deionized water, after ultrasonic dispersion for 40min, fully dissolve in a water bath at 95°C to form a 15% PVA solution. Weigh 20g of NVP and dissolve it in PVA solution when the temperature drops to 40-50°C, keep the temperature constant, pass through nitrogen protection, add 8g of hydrogen peroxide with a mass fraction of 30% as an initiator, and 10g of a mass fraction of 25% ammonia as a Activator, adjust the pH of the mixed solution to 8-9, stir and react at 800 rpm for 1-2 hours, until the temperature of the mixed solution rises and then decreases. Then add 1.5g of N,N-methylenebisacrylamide, stir at 700 rpm for 10 minutes, let stand to defoam, freeze at -30°C for 12 hours, then take it out and thaw at room temperature for 4 hours at 20°C. Repeat the operation 7 times, soak and rinse with water to remove unreacted cross-linking agent.

Embodiment 3

[0034] Weigh 30g of PVA and add 170g of dimethyl sulfoxide, after ultrasonic dispersion for 40min, fully dissolve in a water bath at 95°C to form a 15% PVA solution. Weigh 10g of NVP and dissolve it in PVA solution when the temperature drops to 70°C, keep the temperature constant, pass through nitrogen protection, add 3g of hydrogen peroxide with a mass fraction of 30% as an initiator, and 5g of ammonia with a mass fraction of 25% as an activator , adjust the pH of the mixed solution to be 7-9, stir and react at a speed of 800 rpm for 1-2h, until the temperature of the mixed solution increases and then decreases. Then add 1.5g of N,N-methylenebisacrylamide, stir at 1000 rpm for 10 minutes, let stand to defoam, freeze at -30°C for 12 hours, then take it out and thaw at room temperature 20°C for 4 hours. Repeat the operation 7 times, soak and rinse with water to remove dimethyl sulfoxide and unreacted cross-linking agent.

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Abstract

The invention relates to a substitute material for rehabilitating articular cartilage and a preparation method thereof. A substitute material body is a porous hydrogel structural body with an interpenetrating network structure polymerized by PVA and PVP type components; the mass ratio of polyvinyl alcohol to pyrrolidone type components is 1: (0.01 to 1); and the elastic modulus is 0.5 to 10 MPa. The substitute material is prepared by adopting an in-situ solution polymerization method and the preparation method comprises the following steps: dissolving the monomers of the PVP type components in PVA solution and mixing completely and uniformly; adding a free radical initiator and polymerizing to obtain a blending system of the PVP type components; then adding a cross-linking agent to continuously carry out cross-linking polymerization reaction to obtain a hydrogel product; and finally preparing the substitute material through repeatedly freezing / unfreezing till the hardness reach the expected index. The substitute material is of a porous structure with an interpenetrating network which can contain a large amount of water and is a permeable material; liquid can be permeated and extruded as a lubricant under the load action; and furthermore, the substitute material has good mechanical strength approximate to the mechanical property of the articular cartilage, is similar to natural cartilage tissues, and has good biological compatibility.

Description

technical field [0001] The invention relates to a substitute material for articular cartilage repair and a preparation method of the material. Background technique [0002] Cartilage damage is a relatively common disease in orthopedics. Trauma, osteoarthritis, osteomalacia, etc. can all cause damage or defect of cartilage and subchondral bone. The incidence of bone and cartilage caused by trauma and social aging continues to increase, especially the lesions of articular cartilage increase significantly. Since Hunter proposed in 1743 that cartilage cannot be repaired once it is damaged, there is still no ideal way to repair cartilage defects. Studies have shown that the repair ability of adult articular cartilage is very limited, and the diameter <3mm can be partially or completely self-repaired, and the diameter>3mm cannot be self-repaired. A series of experiments have confirmed that it is difficult to repair the deeper and larger joint hyaline cartilage, and it wil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/56A61L27/52C08J3/24C08L29/04C08L39/06
Inventor 左奕李玉宝龚梅
Owner SICHUAN UNIV
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